Detalhe da pesquisa
1.
Chromatin conformational changes at human satellite II contribute to the senescence phenotype in the tumor microenvironment.
Proc Natl Acad Sci U S A
; 120(32): e2305046120, 2023 08 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37523559
2.
Quabodepistat (OPC-167832), a Novel Antituberculosis Drug Candidate: Enhancing Oral Bioavailability via Cocrystallization and Mechanistic Analysis of Bioavailability in Two Cocrystals.
Mol Pharm
; 21(1): 358-369, 2024 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38099729
3.
Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer.
Proc Natl Acad Sci U S A
; 118(35)2021 08 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-34426493
4.
Transcriptomic intratumor heterogeneity of breast cancer patient-derived organoids may reflect the unique biological features of the tumor of origin.
Breast Cancer Res
; 25(1): 21, 2023 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36810117
5.
Quantitative Model Analysis and Simulation of Pharmacokinetics and Metastasis-Associated Lung Adenocarcinoma 1 RNA Knockdown Effect After Systemic Administration of Cholesterol-Conjugated DNA/RNA Heteroduplex Oligonucleotide Crossing Blood-Brain Barrier of Mice.
J Pharmacol Exp Ther
; 384(1): 197-204, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36273821
6.
Effects of combinations of gapmer antisense oligonucleotides on the target reduction.
Mol Biol Rep
; 50(4): 3539-3546, 2023 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-36787053
7.
YBX1 Regulates Satellite II RNA Loading into Small Extracellular Vesicles and Promotes the Senescent Phenotype.
Int J Mol Sci
; 24(22)2023 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38003589
8.
Identification of Novel Senescent Markers in Small Extracellular Vesicles.
Int J Mol Sci
; 24(3)2023 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36768745
9.
Cellular senescence and senescence-associated secretory phenotype via the cGAS-STING signaling pathway in cancer.
Cancer Sci
; 111(2): 304-311, 2020 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-31799772
10.
DNA Damage Regulates Senescence-Associated Extracellular Vesicle Release via the Ceramide Pathway to Prevent Excessive Inflammatory Responses.
Int J Mol Sci
; 21(10)2020 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32466233
11.
Platelet-activating factor podoplanin: from discovery to drug development.
Cancer Metastasis Rev
; 36(2): 225-234, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28674748
12.
In vitro and in vivo evaluations of the P-glycoprotein-mediated efflux of dibenzoylhydrazines.
Toxicol Appl Pharmacol
; 298: 40-7, 2016 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26995013
13.
Structure-activity relationships of dibenzoylhydrazines for the inhibition of P-glycoprotein-mediated quinidine transport.
Bioorg Med Chem
; 24(14): 3184-91, 2016 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27262425
14.
Targeting DHX9 Triggers Tumor-Intrinsic Interferon Response and Replication Stress in Small Cell Lung Cancer.
Cancer Discov
; 14(3): 468-491, 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38189443
15.
FOXD1 is associated with poor outcome and maintains tumor-promoting enhancer-gene programs in basal-like breast cancer.
Front Oncol
; 13: 1156111, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37234983
16.
Acute loss of DP1, but not DP2, induces p53 mRNA and augments p21Waf1/Cip1 and senescence.
Cell Biochem Funct
; 30(1): 54-60, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22012588
17.
Pericentromeric repetitive ncRNA regulates chromatin interaction and inflammatory gene expression.
Nucleus
; 13(1): 74-78, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35167425
18.
Hepatocyte growth factor derived from senescent cells attenuates cell competition-induced apical elimination of oncogenic cells.
Nat Commun
; 13(1): 4157, 2022 07 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35851277
19.
RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells.
Commun Biol
; 5(1): 1420, 2022 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36577784
20.
Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS.
Nat Biotechnol
; 39(12): 1529-1536, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34385691