User experience with a parenting chatbot micro intervention.

Background: The use of chatbots to address mental health conditions have become increasingly popular in recent years. However, few studies aimed to teach parenting skills through chatbots, and there are no reports on parental user experience. Aim: This study aimed to assess the user experience of a parenting chatbot micro intervention to teach how to praise children in a Spanish-speaking country. Methods: A sample of 89 parents were assigned to the chatbot micro intervention as part of a randomized controlled trial study. Completion rates, engagement, satisfaction, net promoter score, and acceptability were analyzed. Results: 66.3% of the participants completed the intervention. Participants exchanged an average of 49.8 messages (SD = 1.53), provided an average satisfaction score of 4.19 (SD = .79), and reported that they would recommend the chatbot to other parents (net promoter score = 4.63/5; SD = .66). Acceptability level was high (ease of use = 4.66 [SD = .73]; comfortability = 4.76 [SD = .46]; lack of technical problems = 4.69 [SD = .59]; interactivity = 4.51 [SD = .77]; usefulness for everyday life = 4.75 [SD = .54]). Conclusions: Overall, users completed the intervention at a high rate, engaged with the chatbot, were satisfied, would recommend it to others, and reported a high level of acceptability. Chatbots have the potential to teach parenting skills however research on the efficacy of parenting chatbot interventions is needed.

Physical interactions between mast cells and eosinophils: a novel mechanism enhancing eosinophil survival in vitro.

BACKGROUND: Mast cells (MCs) and eosinophils (Eos) are the key effector cells of the allergic reaction. Although classically associated with different stages of the response, the cells co-exist in the inflamed tissue in the late and chronic phases in high numbers and are likely to cross-talk. While some mediators of MCs are known to affect Eos biology and vice versa, paracrine and physical interplay between the two cells has not been described yet. We aimed to investigate whether intercellular MC-Eos communication could take place in the allergic response and exert functional bidirectional changes on the cells. METHODS: Tissue sections from various allergic disorders were specifically stained for both cells. Human cord blood-derived MCs and peripheral blood Eos, co-cultured under different conditions, were studied by advanced microscopy and flow cytometry. RESULTS: Several co-localized MC-Eos pairs were detected in human nasal polyps and asthmatic bronchi, as well in mouse atopic dermatitis. In vitro, MCs and Eos formed stable conjugates at high rates, with clear membrane contact. In the presence of MCs, Eos were significantly more viable under several co-culture conditions and at both IgE-activated and steroid-inhibited settings. MC regulation of Eos survival required communication through soluble mediators but was even more dependent on physical cell-cell contact. CONCLUSIONS: Our findings provide the first evidence for a complex network of paracrine and membrane interactions between MCs and Eos. The prosurvival phenotype induced by this MC-Eos interplay may be critical for sustaining chronic allergic inflammation.

Quantum master equations from classical Lagrangians with two stochastic forces.

We show how a large family of master equations, describing quantum Brownian motion of a harmonic oscillator with translationally invariant damping, can be derived within a phenomenological approach, based on the assumption that an environment can be simulated by two classical stochastic forces. This family is determined by three time-dependent correlation functions (besides the frequency and damping coefficients), and it includes as special cases the known master equations, whose dissipative part is bilinear with respect to the operators of coordinate and momentum.

Female pelvic anatomy: Are we there yet? Assessment of the knowledge of residents.

BACKGROUND: Anatomy is considered a keystone in medical education and pelvic anatomy comprehension is the groundwork of the understanding of birthing process and pelvic surgery. The objectives of this study were to assess the state of the knowledge in anatomy of ob/gyn residents. MATERIEL AND METHODS: The assessment of pelvic anatomy knowledge of 52 ob/gyn residents was performed in a cross-sectional analysis in Lille University Hospital in 2015. A survey was designed with educational and clinical objectives on pelvic anatomy to assess the resident's real level of knowledge. RESULTS: Ob/gyn residents were not satisfied with the learning of anatomy at the medical school with a global rate of 92% of unhappy residents. The global score in anatomy for the overall population was 6.67±0.46 (on 20 points). The eldest residents had a significant better global score than the youngest, 9.24±0.76 vs. 5.53±0.46 (P<0.0001). CONCLUSIONS: Ob/gyn residents should be educated to a specific teaching in anatomy throughout their residency program. Some strategies could improve the level of ob/gyn residents in anatomy and the survey showed the attractiveness of residents to modern medias, such as anatomy videos, compared to current historical anatomy lectures human cadaveric dissections or books.

[Maternal and neonatal outcomes according to gestational weight gain in twin pregnancies: Are the IOM guidelines associated with better issues?] / Conséquences maternelles et néonatales de la prise de poids pendant les grossesses gémellaires : les recommandations IOM 2009 traduisent-elles de meilleures issues ?

OBJECTIVE: Our objective was to evaluate the relevance of the Institute of medicine (IOM) guidelines of weight gain during twin pregnancies, published in 2009. METHODS: We systematically reviewed the data from Medline and the Cochrane Library databases. We only selected the articles which studied the neonatal and maternal outcomes according to maternal gestational weight gain (GWG), depending on the prepregnancy BMI (body mass index). Five clinical parameters had been mainly studied: gestational hypertensive disorders (gestational hypertension and preeclampsia), gestational diabetes mellitus (GDM), preterm births, and birth weights. RESULTS: We identified 8 articles, corresponding to our inclusion criteria. They all present methodological weaknesses (observational retrospective design, small population samples and there were sometimes issues to properly determine the GWG). An excessive weight gain was associated with an increasing of gestational hypertensive disorders. Regarding GDM, the results were inconsistent, suggesting a poor correlation between GWG and occurrence of GDM. Preterm births and low birth weights were more frequent when the GWG did not reach the recommendations. CONCLUSION: Although based on low scientific evidence, the IOM recommendations for GWG in twin pregnancies should be used in daily practice.

Laparoscopic management of acute small bowel obstruction.

BACKGROUND: As minimally invasive surgery gains ground, it is entering realms previously considered to be relative contraindications for laparoscopy. We reviewed our experience with the laparoscopic approach to the management of small bowel obstruction (SBO). METHODS: From December 1997 to November 2002, 65 patients underwent laparoscopic treatment for SBO. The operating surgeon attempted to identify a transitional point between distended and collapsed bowel and then address the obstruction at that point. RESULTS: Postoperative adhesions were the cause of the obstruction in 44 patients. Tumor was identified in five cases, hernia in four, bezoar in three, intussusception in three, acute appendicitis and pseudoobstruction in two cases each, and terminal ileitis in one case. The diagnostic accuracy of laparoscopy was 96.9%. Thirty-four patients (52%) were treated by laparoscopy alone. Thirteen patients (20%) required a small target incision for segmental resection. Eighteen operations were converted to formal laparotomy. The mean laparoscopy time was 40 min (range, 25-160). Patients resumed oral intake in 1-3 days. The complication rate was 6.4%. There were two deaths, but none related to laparoscopy. The mean hospital stay was 4.2 days. CONCLUSIONS: Laparoscopy is a useful minimally invasive technique for the management of acute SBO. It is an excellent diagnostic tool and, in most cases, a therapeutic surgical approach in patients with SBO. However, a significant number of patients will require conversion.

Laparoscopic treatment of gastroduodenal perforations: comparison with conventional surgery.

BACKGROUND: Laparoscopic techniques have been proposed as an alternative to open surgery for the treatment of peptic ulcer perforation. This study compared the outcome of laparoscopic and open approaches for the repair of gastroduodenal perforations. METHODS: A retrospective review was conducted with 134 consecutive patients treated for gastroduodenal perforations. These patients included 122 with perforated duodenal ulcers, 10 with perforated gastric ulcers, and 2 with iatrogenic duodenal perforations. Whereas 68 patients were treated laparoscopically, 66 patients underwent conventional (open) surgery. RESULTS: Laparoscopic repair was successful in 65 cases (96 %). The mean operating time was shorter with the laparoscopic technique (68 vs 59 min), but the difference was not significant. The duration of postoperative nasogastric aspiration and time to resumed oral intake were shorter in the laparoscopic group (2.6 vs 4.1 days and 4.4 vs. 5.2 days, respectively; p = 0.043). The postoperative analgetic requirements, and overall complications rate were significantly lower after laparoscopic surgery (p = 0.03 and p = 0.004, respectively). There was no statistically significant difference in hospital stay (5.1 vs 6.1 days) or mortality rate between the two procedures. CONCLUSION: Laparoscopic repair of gastroduodenal perforations is a safe alternative treatment offering certain significant short-term advantages.

Early oral feeding following removal of nasogastric tube in gastrointestinal operations. A randomized prospective study.

A study was conducted over a 23-month period to determine the possibility of early postoperative oral feeding after removal of a nasogastric tube in patients undergoing gastrointestinal operations. One hundred seventy-one patients were prospectively randomized into two groups. The first group began liquid oral intake 4 hours after removal of the tube. The second group began an ordinary solid intake soon after nasogastric tube removal. The criterion to remove the tube was based on normal bowel sounds heard by at least two senior surgeons. There was no significant difference between both groups concerning the occurrence of gastrointestinal disturbances following tube removal. Most of the disorders were observed after lower intestinal tract operations. Nine patients in the first group and seven patients in the second group required reinsertion of a nasogastric tube. We suggest that early solid intake immediately after nasogastric tube removal can safely be used in gastrointestinal operations.

Posttraumatic autotransplantation of spleen tissue.

Clinical and laboratory studies have documented high susceptibility to pneumococcal infection in asplenic humans and animals. Splenic autotransplantation has been suggested as a method of preserving function. Autotransplantation of irreparably damaged spleens in humans preserved splenic functions. Ten patients operated on for blunt abdominal trauma required unavoidable splenectomy. In each, autotransplantation of the removed spleen (roughly 50 g) was performed. Postoperative studies of splenic functions revealed disappearance of Howell-Jolly bodies from peripheral blood. Levels of IgM, which were initially significantly depressed, returned to normal and there were normal technetium Tc 99m sulfur colloid scans ten weeks after surgery. All patients are alive and healthy. Our data suggest that autotransplantation of spleen is a safe alternative method for preserving splenic function when total splenectomy is mandatory for hemostasis.

Surgical approach and outcome in torsion of testis.

A total of 31 patients with acute torsion treated over a fifteen-year period are reviewed. The peak incidence of the disease, its seasonal variations, predisposing factors, surgical procedure, and clinical outcome are analyzed. Most of the patients were operated upon via an inguinal incision and underwent detorsion and fixation or untwisting only of the involved testis. The contralateral one was never anchored. All patients were asked to complete a questionnaire, with 2 of 3 responding from one to fifteen years (mean, 6.7 years) after surgery. None underwent recurrent surgery on either testicle. We conclude that fixation of the testes, both detorsioned and normal is not necessary.

Use of the Foley catheter in the repair of adult indirect inguinal hernias.

A widely opened internal ring and weakness of the transversalis fascia are the major defects in adult indirect inguinal hernia. Reducing the size of the ring and reinforcement of the transversalis fascia prevent hernial recurrence. During the repair, introduction of a Foley catheter into the internal ring and inflation of its balloon displaces the inferior epigastric vessels medially and the spermatic cord laterally. This position of the balloon enables a safe reconstruction of the internal ring without injury to the epigastric vessels and prevents tightening of the cord. This technique was successfully employed on 75 adult patients who underwent repair of an indirect inguinal hernia without complications.

A simplified method for ring removal from an edematous finger.

A simple method for removal of a ring from an edematous finger is described. This method enabled us to successfully remove rings in 32 patients.

Improved zipper closure of the abdominal wall in patients requiring multiple intra-abdominal operations.

Optimal management of pancreatic abscess and septic complications of acute pancreatitis remains controversial. With the "open packing" approach, repeated closure of the midline fascia is complicated by loss of tissue integrity and suture strength. An improved zipper closure of the abdominal wall in six patients with pancreatic abscess is presented. Improvements included: (1) using a separating jacket-type zipper to allow maximal intraoperative exposure; (2) employing a removable tuck for expansion of the patch covering the wound; (3) substituting a nonmeshed polytetrafluoroethylene material for the polypropylene mesh to prevent adherence to the underlying viscera; and (4) creating a flap underneath the zipper teeth to protect the underlying tissue from injury. Satisfactory results were achieved with the improved zipper technique.

Laparoscopic repair of large incisional hernias.

BACKGROUND: Traditional approaches to incisional hernias (IH)--particularly in cases with large fascial defects--are plagued by a significant recurrence rate as well as frequent wound infections. The laparoscopic repair of incisional hernias was designed to offer a minimally invasive and tension-free technique that yields less morbidity and fewer recurrences than the standard open repair. Several years ago, we adopted the laparoscopic technique in our department and set out to appraise its touted advantages. METHODS: During the years 1997-2000, 103 patients underwent laparoscopic IH repair with implanted Dual Gore-tex mesh. Forty percent of them were obese, and 41% had undergone more than one previous attempt at conventional repair. All patients were discharged home within 24-72 hs. RESULTS: In three patients, the operation was converted to open surgery due to severe adhesions and technical difficulties. In two cases, inadvertent enterotomies were repaired laparoscopically, and since there was no major spillage, the repair was continued as planned, with no adverse consequences. Twelve patients underwent additional laparoscopic procedures at the initial operation. Two graft infections and four recurrences were observed during the 1-49 month follow-up period. CONCLUSIONS: Laparoscopic IH repair is technically feasible and safe in patients with large fascial defects as well as in obese patients. This operation decreases postoperative pain, hastens the recovery period, and reduces postoperative morbidity and recurrence.

The use of laparoscopy in abdominal emergencies.

BACKGROUND: The purpose of this article is to describe our experience using laparoscopy in the management of emergent and acute abdominal conditions. METHODS: Between March 1997 and November 2001, 277 consecutive minimally invasive procedures were performed for various nontrauma surgical emergencies. The indications for operation were nonspecific abdominal pain in 129 cases (46%), peritonitis in 64 cases (23%), small bowel obstruction in 52 cases (19%), complications after previous surgery or invasive procedures in 24 cases (9%), and sepsis of unknown origin in 8 cases (3%). RESULTS: Laparoscopy obtained a correct diagnosis in 98.6% of the cases. In 207 patients (75%), the procedure was completed laparoscopically. An additional 35 patients (12.5%) required a target incision. The remaining 35 patients (12.5%) underwent formal laparotomy. The morbidity rate was 5.8%. No laparoscopy-related mortality was observed. CONCLUSIONS: For patients with abdominal emergencies, the laparoscopic approach provides diagnostic accuracy and therapeutic options, avoids extensive preoperative studies, averts delays in operative intervention, and appears to reduce morbidity.

Left gastric artery as an alternative for arterial reconstruction in orthotopic liver transplantation.

The hepatic arterial blood supply is indispensable for the survival of the graft during liver transplantation. Inadequacies in the recipient hepatic artery mandate arterial reconstruction different from the preferred method of direct anastomosis. We report the use of the left gastric artery as an attractive alternative for reconstructing the arterial blood supply of a transplanted liver.

Effects of random migration in population dynamics.

We study the influence of random migration of a species (may be insects) in the population dynamics when initially all the individuals live in a primordial site (their habitats may be trees). We assume (i) a finite number of sites, (ii) that migration occurs randomly to nearest neighbors, and (iii) an on-site age-structured population whose size varies according to Ricker's map. We find that even for a very small migration rate, the population density becomes appreciably affected. If migration is not allowed, depending on the value of the characteristic parameters, the population may display a chaotic oscillation; however, with migration permitted, the chaos is reduced or even suppressed, and the population density will oscillate with period 2 or period 4. We examined the effects of migration through higher-order iterations of the map, entropy, and time correlation function. We also considered a long chain, analyzing (a) the spatial correlation between sites, noting the occurrence of a transition in the correlation function between sites separated by odd and even units of distance and (b) the fluctuations in time of the populations when initially all sites are populated.

A facilitated technique for hepatectomy of porcine liver.

The swine liver has been used for experimental transplantation and as an ex vivo support system for patients with fulminant hepatic failure. Preservation of liver function after the cold storage period can be accomplished by complying with several key steps during the procurement: Keep the procedure short, provide extensive exposure, allow only minimal dissection, irrigate the portal system through the splenic vein and thereby obtain regular blood flow through the organ up to the clamping point, and ice the liver abruptly in situ. This retrieval technique was used and evaluated in 10 pigs. The method allowed a short and successful organ procurement while preserving normal function of the liver ex vivo.

Use of tissue adhesives in the repair of lacerations in children.

During the last 5 years, over 1,500 minor lacerations in children were treated in the emergency room of Nahariya Regional Hospital, by the adhesive "Hystoacryl Blue," with gratifying results. The method, its advantages, and special precautions are described.