1.
Bioconjug Chem
; 22(8): 1723-8, 2011 Aug 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21744777
RESUMO
Conditions for facile solution-phase amide conjugation of amine-modified siRNA with a diverse set of carboxylic acid partners using the coupling reagent HATU are described. These conditions eliminate the need for isolated activated esters and allow for rapid access to conjugates with a wide range of lipophilicity and functionality in good yield.