Detalhe da pesquisa
1.
Discovery of ASP6918, a KRAS G12C inhibitor: Synthesis and structure-activity relationships of 1-{2,7-diazaspiro[3.5]non-2-yl}prop-2-en-1-one derivatives as covalent inhibitors with good potency and oral activity for the treatment of solid tumors.
Bioorg Med Chem
; 98: 117581, 2024 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38176113
2.
Characterisation of a novel KRAS G12C inhibitor ASP2453 that shows potent anti-tumour activity in KRAS G12C-mutated preclinical models.
Br J Cancer
; 126(5): 744-753, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34795410
3.
Discovery and biological evaluation of 1-{2,7-diazaspiro[3.5]nonan-2-yl}prop-2-en-1-one derivatives as covalent inhibitors of KRAS G12C with favorable metabolic stability and anti-tumor activity.
Bioorg Med Chem
; 71: 116949, 2022 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35926326
4.
l-Tryptophan-starved cultivation enhances S-allyl-l-cysteine synthesis in various food-related microorganisms.
Biosci Biotechnol Biochem
; 86(6): 792-799, 2022 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35388878
5.
Effects of dutasteride in a rat model of chemically induced prostatic inflammation-Potential role of estrogen receptor ß.
Prostate
; 80(16): 1413-1420, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32941694
6.
The role of prostaglandin and E series prostaglandin receptor type 4 receptors in the development of bladder overactivity in a rat model of chemically induced prostatic inflammation.
BJU Int
; 124(5): 883-891, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31166645
7.
The effect of herpes simplex virus vector-mediated gene therapy of protein phosphatase 1α on bladder overactivity and nociception.
Neurourol Urodyn
; 38(2): 582-590, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30499116
8.
Cedar Pollinosis and Mortality: A Population-Based Prospective Cohort Study in Japan.
J Epidemiol
; 29(2): 61-64, 2019 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29937471
9.
Discovery of N-{2-Methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-N'-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine (ASP3026), a Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor.
Chem Pharm Bull (Tokyo)
; 66(3): 251-262, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29491259
10.
Laparoendoscopic single-site nephrectomy for hemodialysis patients with dialysis-related renal tumors.
Minim Invasive Ther Allied Technol
; 27(3): 153-159, 2018 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-28604288
11.
Effects of Estrogen Receptor ß Stimulation in a Rat Model of Non-Bacterial Prostatic Inflammation.
Prostate
; 77(7): 803-811, 2017 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-28181685
12.
Gilteritinib, a FLT3/AXL inhibitor, shows antileukemic activity in mouse models of FLT3 mutated acute myeloid leukemia.
Invest New Drugs
; 35(5): 556-565, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28516360
13.
Effects of an alpha1A/D-adrenoceptor antagonist, naftopidil, and a phosphodiesterase type 5 inhibitor, tadalafil, on urinary bladder remodeling in rats with spinal cord injury.
Neurourol Urodyn
; 36(6): 1488-1495, 2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-27701772
14.
Identification of enzymes responsible for extracellular alginate depolymerization and alginate metabolism in Vibrio algivorus.
Appl Microbiol Biotechnol
; 101(4): 1581-1592, 2017 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-27915375
15.
IGF-1 as an Important Endogenous Growth Factor for Recovery from Impaired Urethral Continence Function in Rats with Simulated Childbirth Injury.
J Urol
; 195(6): 1927-35, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26767520
16.
Production of infectious HCV genotype 1b virus in cell culture using a novel Set of adaptive mutations.
BMC Microbiol
; 16(1): 224, 2016 Sep 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27678340
17.
Persistent replication of a hepatitis C virus genotype 1b-based chimeric clone carrying E1, E2 and p6 regions from GB virus B in a New World monkey.
Microbiol Immunol
; 60(1): 26-34, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26634303
18.
Age-related changes in bladder function with altered angiotensin II receptor mechanisms in rats.
Neurourol Urodyn
; 35(8): 908-913, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26250880
19.
Preparation and Characterization of Four Stereoisomers of Monatin.
Chem Pharm Bull (Tokyo)
; 64(8): 1161-71, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27477656
20.
[MASSIVE HEMORRHAGE FROM THE FISTULA FORMATION BETWEEN CUTANEOUS URETEROSTOMY AND INFERIOR EPIGASTRIC ARTERY: A CASE REPORT].
Nihon Hinyokika Gakkai Zasshi
; 106(2): 127-31, 2015 Apr.
Artigo
em Japonês
| MEDLINE | ID: mdl-26415365