Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 7 de 7
Filtrar
1.
Scand J Med Sci Sports ; 25 Suppl 1: 96-103, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-25943660

RESUMO

Acute acetaminophen (ACT) ingestion has been reported to reduce thermal strain during cycling in the heat. In this study, nine active participants ingested 20 mg of ACT per kg of total body mass (ACT) or a placebo (PLA), 60 min prior to cycling at a fixed rate of metabolic heat production (ACT: 8.3 ± 0.3 W/kg; PLA: 8.5 ± 0.5 W/kg), which was equivalent to 55 ± 6% VO2max , for 60 min at 34.5 ± 0.1 °C, 52 ± 1% relative humidity. Resting rectal temperature (Tre ; ACT: 36.70 ± 0.17 °C; PLA: 36.80 ± 0.16 °C, P = 0.24), esophageal temperature (Tes ; ACT: 36.54 ± 0.22 °C; PLA: 36.61 ± 0.17 °C, P = 0.50) and mean skin temperature (Tsk ; ACT: 34.00 ± 0.14 °C; PLA: 33.96 ± 0.20 °C, P = 0.70) were all similar among conditions. At end-exercise, no differences in ΔTre (ACT: 1.12 ± 0.15 °C; PLA: 1.11 ± 0.21 °C, P = 0.92), ΔTes (ACT: 0.90 ± 0.28 °C; PLA: 0.88 ± 0.23 °C, P = 0.84), ΔTsk (ACT: 0.80 ± 0.39 °C; PLA: 0.70 ± 0.46 °C, P = 0.63), mean local sweat rate (ACT: 1.02 ± 0.15 mg/cm(2) /min; PLA: 1.02 ± 0.13 mg/cm(2) /min, P = 0.98) and whole-body sweat loss (ACT: 663 ± 83 g; PLA: 663 ± 77 g, P = 0.995) were evident. Furthermore, ratings of perceived exertion and thermal sensation and thermal comfort were not different between ACT and PLA conditions. In conclusion, ACT ingested 60 min prior to moderate intensity exercise in hot-humid conditions does not alter physiologic thermoregulatory control nor perceived strain.


Assuntos
Acetaminofen/farmacologia , Antipiréticos/farmacologia , Temperatura Corporal/efeitos dos fármacos , Exercício Físico/fisiologia , Transtornos de Estresse por Calor/prevenção & controle , Temperatura Alta/efeitos adversos , Umidade/efeitos adversos , Acetaminofen/uso terapêutico , Adulto , Antipiréticos/uso terapêutico , Ciclismo/fisiologia , Regulação da Temperatura Corporal/efeitos dos fármacos , Regulação da Temperatura Corporal/fisiologia , Método Duplo-Cego , Esquema de Medicação , Feminino , Transtornos de Estresse por Calor/etiologia , Humanos , Masculino , Esforço Físico/efeitos dos fármacos , Esforço Físico/fisiologia , Sudorese/efeitos dos fármacos , Resultado do Tratamento
2.
Sports Med ; 50(10): 1709-1727, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32623642

RESUMO

INTRODUCTION: Menthol topical application and mouth rinsing are ergogenic in hot environments, improving performance and perception, with differing effects on body temperature regulation. Consequently, athletes and federations are beginning to explore the possible benefits to elite sport performance for the Tokyo 2021 Olympics, which will take place in hot (~ 31 °C), humid (70% RH) conditions. There is no clear consensus on safe and effective menthol use for athletes, practitioners, or researchers. The present study addressed this shortfall by producing expert-led consensus recommendations. METHOD: Fourteen contributors were recruited following ethical approval. A three-step modified Delphi method was used for voting on 96 statements generated following literature consultation; 192 statements total (96/96 topical application/mouth rinsing). Round 1 contributors voted to "agree" or "disagree" with statements; 80% agreement was required to accept statements. In round 2, contributors voted to "support" or "change" their round 1 unaccepted statements, with knowledge of the extant voting from round 1. Round 3 contributors met to discuss voting against key remaining statements. RESULTS: Forty-seven statements reached consensus in round 1 (30/17 topical application/rinsing); 14 proved redundant. Six statements reached consensus in round 2 (2/4 topical application/rinsing); 116 statements proved redundant. Nine further statements were agreed in round 3 (6/3 topical application/rinsing) with caveats. DISCUSSION: Consensus was reached on 62 statements in total (38/24 topical application/rinsing), enabling the development of guidance on safe menthol administration, with a view to enhancing performance and perception in the heat without impairing body temperature regulation.


Assuntos
Administração Tópica , Desempenho Atlético/fisiologia , Mentol/administração & dosagem , Antissépticos Bucais , Substâncias para Melhoria do Desempenho , Técnica Delphi , Humanos , Tóquio
3.
Am J Cardiol ; 76(11): 776-80, 1995 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-7572653

RESUMO

This study was designed to determine the safety and efficacy of extended, continuous infusion of urokinase plus stent deployment to treat older saphenous vein bypass grafts obstructed by both thrombus and atheromatous material. Thirty patients with angiographic evidence of thrombus and atheromatous material obstructing older vein grafts (mean age 8.3 years) underwent the combined interventions of urokinase infusion and stent deployment. The continuous infusion of urokinase was administered directly into each obstructed vein graft over a mean of 20.5 +/- 8.1 hours (median dose 2.2 +/- 0.7 million units). Stents were deployed at the sites of atheromatous obstruction either before (5 patients) or after (25 patients) infusion of urokinase. Twenty-eight of the 30 patients were successfully treated with the combined interventions (success rate 93.3%). In these 28 patients, percent diameter stenosis at the site of obstruction decreased from 86.0% to -0.2% and Thrombolysis in Myocardial Infarction trial flow increased from 1.0 to 2.5. Two patients (6.7%) developed stent thrombosis followed by myocardial infarction (1 with Q-wave infarction, 3.3%) and congestive heart failure. Minor complications included non-Q-wave myocardial infarction (5 patients, 16.7%) and access-site hemorrhage (5 patients, 16.7%). At 2-week follow-up, anginal symptoms were decreased in all 28 successfully treated patients. At 7.2 +/- 3.7-month follow-up, 5 of the 28 successfully treated patients (17.9%) had reacceleration of angina and angiographically documented restenosis at the site of stent deployment.(ABSTRACT TRUNCATED AT 250 WORDS)


Assuntos
Ponte de Artéria Coronária , Doença da Artéria Coronariana/terapia , Trombose Coronária/terapia , Oclusão de Enxerto Vascular/terapia , Ativadores de Plasminogênio/uso terapêutico , Veia Safena/transplante , Stents , Terapia Trombolítica , Ativador de Plasminogênio Tipo Uroquinase/uso terapêutico , Idoso , Distribuição de Qui-Quadrado , Terapia Combinada , Angiografia Coronária , Doença da Artéria Coronariana/diagnóstico por imagem , Doença da Artéria Coronariana/tratamento farmacológico , Doença das Coronárias/etiologia , Trombose Coronária/diagnóstico por imagem , Trombose Coronária/tratamento farmacológico , Feminino , Seguimentos , Oclusão de Enxerto Vascular/diagnóstico por imagem , Oclusão de Enxerto Vascular/tratamento farmacológico , Hemorragia/etiologia , Humanos , Infusões Intravenosas , Masculino , Pessoa de Meia-Idade , Infarto do Miocárdio/etiologia , Ativadores de Plasminogênio/administração & dosagem , Ativadores de Plasminogênio/efeitos adversos , Prognóstico , Estudos Prospectivos , Stents/efeitos adversos , Ativador de Plasminogênio Tipo Uroquinase/administração & dosagem , Ativador de Plasminogênio Tipo Uroquinase/efeitos adversos
4.
Crit Care Nurs Clin North Am ; 11(3): 333-48, 1999 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-10786480

RESUMO

Dating from the inception of percutaneous coronary angioplasty, restenosis has been the postprocedural Achilles heel. Despite a decade of research, with a myriad of mechanical devices and pharmacologic agents, this vexing problem has yet to be resolved. Although intracoronary stents have proved effective at restenosis reduction, they have yet to achieve an acceptable level and, in some cases, remain resistant to any treatment. Intracoronary radiation using gamma or beta isotopes, has generated tremendous excitement with promising results. Indeed, the SCRIPPS (Scripps Coronary Radiation to Inhibit Proliferation Post Stenting) trial, which employed gamma radiation, showed a statistically significant reduction in restenosis in a small patient population. Further studies with a variety of isotopes and delivery modalities are currently underway, bringing with them their own assemblage of issues.


Assuntos
Braquiterapia/métodos , Braquiterapia/tendências , Doença das Coronárias/terapia , Angioplastia Coronária com Balão , Braquiterapia/efeitos adversos , Terapia Combinada , Humanos , Garantia da Qualidade dos Cuidados de Saúde/organização & administração , Recidiva , Segurança , Stents , Resultado do Tratamento
6.
Catheter Cardiovasc Interv ; 46(1): 32-5, 1999 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-10348562

RESUMO

At our institution, elective coronary interventions are performed without formal surgical backup. Instead, a policy of "standby cardiopulmonary support" (CPS), and "next-available operating room" is used. Standby CPS requires a perfusionist dedicated to the catheterization laboratory with immediate access to CPS apparatus. Between January 1989 and June 1994 we performed 2,850 elective coronary interventions. Eleven patients (0.4%) required emergency CPS. None of these patients fell into a high-risk category for PTCA (i.e., sole circulation, ejection fraction <20%, unprotected left main). Eight of these (73%) had completion of their coronary intervention while on CPS in the catheterization laboratory. Three patients were sustained on CPS until an operating room became available. All patients required blood transfusions and sustained non-Q-wave myocardial infarctions. Two late in-hospital deaths occurred. Nine patients (82%) were successfully discharged. Standby CPS provides hemodynamic support for patients who sustain a potentially catastrophic event during coronary intervention. Our data suggest that this modality should not be limited to high-risk patients.


Assuntos
Ponte Cardiopulmonar , Doença das Coronárias/terapia , Revascularização Miocárdica/efeitos adversos , Idoso , Idoso de 80 Anos ou mais , Angioplastia Coronária com Balão/efeitos adversos , Aterectomia Coronária/efeitos adversos , Cateterismo Cardíaco , Ponte Cardiopulmonar/métodos , Procedimentos Cirúrgicos Eletivos , Emergências , Humanos , Pessoa de Meia-Idade , Estudos Retrospectivos , Choque/terapia
7.
N Engl J Med ; 336(24): 1697-703, 1997 Jun 12.
Artigo em Inglês | MEDLINE | ID: mdl-9180087

RESUMO

BACKGROUND: In animal models of coronary restenosis, intracoronary radiotherapy has been shown to reduce the intimal hyperplasia that is a part of restenosis. We studied the safety and efficacy of catheter-based intracoronary gamma radiation plus stenting to reduce coronary restenosis in patients with previous restenosis. METHODS: Patients with restenosis underwent coronary stenting, as required, and balloon dilation and were then randomly assigned to receive catheter-based irradiation with iridium-192 or placebo. Clinical follow-up was performed, with quantitative coronary angiographic and intravascular ultrasonographic measurements at six months. RESULTS: Fifty-five patients were enrolled; 26 were assigned to the iridium-192 group and 29 to the placebo group. Angiographic studies were performed in 53 patients (96 percent) at a mean (+/-SD) of 6.7+/-2.2 months. The mean minimal luminal diameter at follow-up was larger in the iridium-192 group than in the placebo group (2.43+/-0.78 mm vs. 1.85+/-0.89 mm, P=0.02). Late luminal loss was significantly lower in the iridium-192 group than in the placebo group (0.38+/-1.06 mm vs. 1.03+/-0.97 mm, P=0.03). Angiographically identified restenosis (stenosis of 50 percent or more of the luminal diameter at follow-up) occurred in 17 percent of the patients in the iridium-192 group, as compared with 54 percent of those in the placebo group (P= 0.01). There were no apparent complications of the treatment. CONCLUSIONS: In this preliminary, short-term study of patients with previous coronary restenosis, coronary stenting followed by catheter-based intracoronary radiotherapy substantially reduced the rate of subsequent restenosis.


Assuntos
Doença das Coronárias/radioterapia , Radioisótopos de Irídio/uso terapêutico , Stents , Idoso , Angioplastia Coronária com Balão , Cateterismo Cardíaco , Terapia Combinada , Angiografia Coronária , Doença das Coronárias/prevenção & controle , Doença das Coronárias/terapia , Vasos Coronários/diagnóstico por imagem , Vasos Coronários/patologia , Intervalo Livre de Doença , Método Duplo-Cego , Feminino , Seguimentos , Humanos , Masculino , Recidiva , Resultado do Tratamento , Ultrassonografia de Intervenção
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA