RESUMO
Prototheca wickerhamii is a rare cause of septic prepatellar bursitis. We report a patient who had no apparent immunodeficiency developed P. wickerhamii prepatellar bursitis following intra-bursal corticosteroid injection. Clinical manifestations could not distinguish Prototheca bursitis from septic bursitis caused by other pathogens. Bursal fluid aspiration sent for direct microscopic examination and cultures could give an early diagnosis. Systemic antifungal therapy with complete surgical excision of infected bursa provided a good outcome.
Assuntos
Bursite/diagnóstico por imagem , Imunocompetência , Infecções/diagnóstico , Prototheca/patogenicidade , Antifúngicos/uso terapêutico , Bursite/tratamento farmacológico , Feminino , Humanos , Infecções/tratamento farmacológico , Imageamento por Ressonância Magnética , Pessoa de Meia-IdadeRESUMO
Nasopharyngeal carcinoma (NPC) is strongly associated with Epstein-Barr virus (EBV) infection. To assess whether EBV DNA detection by polymerase chain reaction (PCR) or presence of specific serum antibody to viral capsid antigen (VCA) was a better marker for screening NPC, nasopharyngeal tissues and blood samples from 58 NPC patients and 24 non-NPC patients (23 with laryngotracheal stenosis and 1 with chronic tonsillitis) were tested for the presence of EBV DNA and serum specific VCA antibodies, respectively. EBV DNA was detected in 56 (96.5%) of NPC patients and 15 (62.5%) of non-NPC controls, with predominantly EBV type A in both groups. On the other hand, specific VCA IgA antibody was detected in the majority of NPC patients: 52 (89.7%) while only 4 (16.7%) were detected in non-NPC controls. Therefore, specific VCA IgA antibody may serve as a better marker for screening NPC than EBV DNA detected by PCR.
Assuntos
Antígenos Virais/imunologia , Proteínas do Capsídeo , Infecções por Vírus Epstein-Barr/diagnóstico , Imunoglobulina A/sangue , Neoplasias Nasofaríngeas/diagnóstico , Reação em Cadeia da Polimerase , Anticorpos Antivirais/sangue , Antígenos Virais/genética , Biomarcadores , DNA Viral/análise , Humanos , Programas de Rastreamento/métodos , Neoplasias Nasofaríngeas/virologia , Valor Preditivo dos Testes , Sensibilidade e EspecificidadeRESUMO
Malignant peripheral nerve sheath tumor is a very rare soft tissue tumor in the general population but there is an increased incidence in patients with neurofibromatosis type 1. Two cases of malignant peripheral nerve sheath tumor associated with neurofibromatosis type 1 whom we were able to follow-up long term are presented. Although wide excision was performed successfully in these patients, they suffered from local recurrence of the tumors shortly after surgery and died with distant metastases. The literature concerning the natural history and the management of this specific condition was reviewed.