Detalhe da pesquisa
1.
A novel technique for the detection of Covid-19 patients with the applications of three-way decisions using variance-based criterion.
Microprocess Microsyst
; 97: 104758, 2023 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-36619210
2.
Phe19 modification of HDM2-p53 PPI inhibitors to alleviate CYP3A4 metabolism/mechanism-based inhibition liability.
Bioorg Med Chem Lett
; 61: 128625, 2022 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35158044
3.
Core modification of substituted piperidines as novel inhibitors of HDM2-p53 protein-protein interaction.
Bioorg Med Chem Lett
; 24(8): 1983-6, 2014 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24656661
4.
Discovery of MK-4688: an Efficient Inhibitor of the HDM2-p53 Protein-Protein Interaction.
J Med Chem
; 64(21): 16213-16241, 2021 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34714078
5.
A facile and efficient synthesis of 3,3-dimethyl isopropylidene proline from (+)-3-carene.
J Org Chem
; 75(4): 1285-8, 2010 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-20108962
6.
Towards the second generation of Boceprevir: Dithianes as an alternative P2 substituent for 2,2-dimethyl cycloproyl proline in HCV NS3 protease inhibitors.
Bioorg Med Chem Lett
; 20(5): 1689-92, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20149655
7.
P4 capped amides and lactams as HCV NS3 protease inhibitors with improved potency and DMPK profile.
Bioorg Med Chem Lett
; 20(2): 567-70, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20004570
8.
The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir: a change in direction in the search for a second generation HCV NS3 protease inhibitor.
Bioorg Med Chem Lett
; 20(8): 2617-21, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20303756
9.
Discovery of potent sulfonamide P4-capped ketoamide second generation inhibitors of hepatitis C virus NS3 serine protease with favorable pharmacokinetic profiles in preclinical species.
Bioorg Med Chem
; 18(5): 1854-65, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20149666
10.
Novel potent inhibitors of hepatitis C virus (HCV) NS3 protease with cyclic sulfonyl P3 cappings.
Bioorg Med Chem Lett
; 19(4): 1105-9, 2009 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19168351
11.
Discovery of novel P3 sulfonamide-capped inhibitors of HCV NS3 protease. Inhibitors with improved cellular potencies.
Bioorg Med Chem
; 17(13): 4486-95, 2009 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19481946
12.
Markers of fetal onset adult diseases.
Indian Pediatr
; 46 Suppl: s48-54, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19279369
13.
Markers of fetal onset adult diseases: a comparison among low birthweight and normal birthweight adolescents.
Indian Pediatr
; 46 Suppl: s43-7, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19279368
14.
Low birthweight babies--outcome at 13 years.
Indian Pediatr
; 46 Suppl: s71-4, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19279376
15.
Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors.
ACS Med Chem Lett
; 7(3): 324-9, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26985323
16.
2'-Modified Guanosine Analogs for the Treatment of HCV.
Nucleosides Nucleotides Nucleic Acids
; 35(6): 277-94, 2016 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27104963
17.
Cyclic sulfones as novel P3-caps for hepatitis C virus NS3/4A (HCV NS3/4A) protease inhibitors: synthesis and evaluation of inhibitors with improved potency and pharmacokinetic profiles.
J Med Chem
; 53(8): 3075-85, 2010 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-20302300
18.
Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor.
ACS Med Chem Lett
; 1(2): 64-9, 2010 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900178
19.
Discovery and structure-activity relationship of P1-P3 ketoamide derived macrocyclic inhibitors of hepatitis C virus NS3 protease.
J Med Chem
; 52(2): 336-46, 2009 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-19102654
20.
Second-generation highly potent and selective inhibitors of the hepatitis C virus NS3 serine protease.
J Med Chem
; 52(5): 1370-9, 2009 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-19196021