Detalhe da pesquisa
1.
Enantioselective Synthesis of 3,3-Difluoropyrrolidin-4-ol, a Valuable Building Block in Medicinal Chemistry.
J Org Chem
; 81(10): 4359-63, 2016 05 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27138111
2.
Discovery of 2-(4-sulfonamidophenyl)-indole 3-carboxamides as potent and selective inhibitors with broad hepatitis C virus genotype activity targeting HCV NS4B.
Bioorg Med Chem Lett
; 26(2): 594-601, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26652483
3.
6-(Azaindol-2-yl)pyridine-3-sulfonamides as potent and selective inhibitors targeting hepatitis C virus NS4B.
Bioorg Med Chem Lett
; 25(4): 781-6, 2015 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25613678
4.
Optimization of potency and pharmacokinetics of tricyclic indole derived inhibitors of HCV NS5B polymerase. Identification of ester prodrugs with improved oral pharmacokinetics.
Bioorg Med Chem
; 22(1): 447-58, 2014 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24275348
5.
Discovery of novel HCV inhibitors: synthesis and biological activity of 6-(indol-2-yl)pyridine-3-sulfonamides targeting hepatitis C virus NS4B.
Bioorg Med Chem Lett
; 23(13): 3947-53, 2013 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23683597
6.
Discovery of an irreversible HCV NS5B polymerase inhibitor.
Bioorg Med Chem Lett
; 23(24): 6585-7, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24252545
7.
Discovery of novel tricyclic indole derived inhibitors of HCV NS5B RNA dependent RNA polymerase.
Bioorg Med Chem
; 21(7): 2007-17, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23434368
8.
Synthesis and SAR of geminal substitutions at the C5' carbosugar position of pyrimidine-derived HCV inhibitors.
Bioorg Med Chem Lett
; 22(22): 6967-73, 2012 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23036957
9.
Synthesis and SAR of pyridothiazole substituted pyrimidine derived HCV replication inhibitors.
Bioorg Med Chem Lett
; 22(17): 5652-7, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22858143
10.
5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors.
Bioorg Med Chem Lett
; 22(9): 3229-34, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22472692
11.
Regioselective cobalt-catalyzed addition of sulfides to unactivated alkenes.
J Org Chem
; 76(15): 6442-6, 2011 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-21696198
12.
Potent ketoamide inhibitors of HCV NS3 protease derived from quaternized P1 groups.
Bioorg Med Chem Lett
; 20(7): 2151-5, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20226659
13.
Towards the second generation of Boceprevir: Dithianes as an alternative P2 substituent for 2,2-dimethyl cycloproyl proline in HCV NS3 protease inhibitors.
Bioorg Med Chem Lett
; 20(5): 1689-92, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20149655
14.
The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir: a change in direction in the search for a second generation HCV NS3 protease inhibitor.
Bioorg Med Chem Lett
; 20(8): 2617-21, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20303756
15.
Discovery of potent sulfonamide P4-capped ketoamide second generation inhibitors of hepatitis C virus NS3 serine protease with favorable pharmacokinetic profiles in preclinical species.
Bioorg Med Chem
; 18(5): 1854-65, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20149666
16.
Challenges in modern drug discovery: a case study of boceprevir, an HCV protease inhibitor for the treatment of hepatitis C virus infection.
Acc Chem Res
; 41(1): 50-9, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18193821
17.
Novel potent inhibitors of hepatitis C virus (HCV) NS3 protease with cyclic sulfonyl P3 cappings.
Bioorg Med Chem Lett
; 19(4): 1105-9, 2009 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19168351
18.
Characterization of resistance mutations against HCV ketoamide protease inhibitors.
Antiviral Res
; 77(3): 177-85, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18201776
19.
Potent and selective small molecule NS3 serine protease inhibitors of Hepatitis C virus with dichlorocyclopropylproline as P2 residue.
Bioorg Med Chem
; 16(4): 1874-83, 2008 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18032054
20.
Characterization of a novel AICARFT inhibitor which potently elevates ZMP and has anti-tumor activity in murine models.
Sci Rep
; 8(1): 15458, 2018 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30337562