1.
Org Lett
; 18(8): 1824-7, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27043010
RESUMO
An efficient synthesis of the C22-C40 domain of the azaspiracids is described. The synthetic route features a Nozaki-Hiyama-Kishi (NHK) coupling and chelation controlled Mukaiyama aldol reaction to access an acyclic intermediate and a double-intramolecular-hetero-Michael addition (DIHMA) to provide the FG-ring system bridged ketal.