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1.
J Eur Acad Dermatol Venereol ; 29(2): 346-352, 2015 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-24909543

RESUMO

BACKGROUND: The incidence of cutaneous melanoma increased dramatically in Iceland during the last two decades of the 20th century. OBJECTIVE: The aim of this study was to investigate the trend in Breslow's tumour thickness during the years 1980-2009. METHODS: The population-based Icelandic Cancer Registry provided information on all cutaneous melanomas diagnosed in the country during the study period, a total of 854 cases. Incidence rates were stratified according to gender, age at diagnosis, year of diagnosis and Breslow's tumour thickness. RESULTS: When stratified by gender and age, the incidence of thin (≤1.0 mm) melanomas increased dramatically in all subgroups. The increase in thin (≤1.0 mm) melanomas was more apparent in women or 2.6 per 100,000 in 1980-1989 to 13.3 in 2000-2009 and especially in young (<50 years) women or from 1.6 to 12.2 per 100,000 during the same period compared to an increase from 0.2 to 3.4 per 100,000 for young (<50 years) men (P < 0.05). In intermediate thickness (1.01-4.0 mm) tumours, the incidence increased only in men over the age of 50 from 2.1 in 1980-1989 to 11.3 per 100,000 in 2000-2009 (P < 0.05). The incidence of thick melanomas (>4 mm) did not increase. The median Breslow's thickness declined from 2.15 mm in 1980-1989 to 0.9 mm in 2000-2009 in males and from 1.0 to 0.6 mm in females for the same period (P < 0.001). CONCLUSION: The rise in melanoma incidence in individuals under 50 years and in women over 50 years was confined to thin tumours. However, among older males there was also an increased incidence of tumours of an intermediate thickness. This could indicate that future melanoma educational campaigns in Iceland should be directed at older individuals, and that older men may need special attention regarding suspicious nevi.


Assuntos
Melanoma/patologia , Neoplasias Cutâneas/patologia , Fatores Etários , Feminino , Humanos , Islândia/epidemiologia , Incidência , Masculino , Melanoma/epidemiologia , Sistema de Registros , Neoplasias Cutâneas/epidemiologia
2.
Scand J Immunol ; 78(6): 529-37, 2013 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-24111693

RESUMO

It is known that NB-UVB therapy can suppress a broad range of immune cells, but the additional effect of bathing in geothermal seawater still remains unclear. To study the influence of treatment on the expression of circulating immune cells contributing to the pathogenesis of psoriasis, six patients with psoriasis were treated with bathing in geothermal seawater two times daily combined with NB-UVB five times/week for 2 weeks and six patients were treated with NB-UVB therapy three times/week for 8 weeks. Disease severity (Psoriasis Area and Severity Index, PASI), chemokines, inflammatory cytokines, T cells and Toll-like receptors in the blood and skin samples were evaluated on enrolment (W0) and at 1 (W1), 3 (W3) and 8 (W8) weeks. Compared with healthy controls, psoriasis patients with active disease had significantly higher proportion of peripheral CLA+ T cells expressing CCR10 and CD103 and T cells with both Th1/Tc1 (CD4+/CD8+ IFN-γ+ or TNF-α+ cells) and Th17/Tc17 (CD4+CD45R0+IL-23R+, CD4+/CD8+ IL-17A+ or IL-22+ cells) phenotypes. Both treatments gave a significant clinical effect; however, bathing in geothermal seawater combined with NB-UVB therapy was more effective than NB-UVB therapy alone. This clinical improvement was reflected by a reduction in circulating CLA+ peripheral blood T cells and by a decreased Th1/Th17 and Tc1/Tc17 inflammatory response. These findings suggest that the inflammatory response in psoriasis is predominantly driven by both CD4+ and CD8+ skin-homing tissue retaining T cells of the Th17/Tc17 lineages.


Assuntos
Banhos , Fontes Termais , Psoríase/imunologia , Psoríase/terapia , Células Th17/imunologia , Terapia Ultravioleta/métodos , Adulto , Antígenos CD/metabolismo , Linfócitos T CD8-Positivos/imunologia , Progressão da Doença , Feminino , Humanos , Cadeias alfa de Integrinas/metabolismo , Interferon gama/sangue , Interleucina-17/sangue , Interleucinas/sangue , Contagem de Linfócitos , Masculino , Pessoa de Meia-Idade , Psoríase/radioterapia , Receptores CCR10/metabolismo , Água do Mar , Pele/citologia , Pele/imunologia , Células Th1/imunologia , Receptores Toll-Like/sangue , Interleucina 22
3.
J Eur Acad Dermatol Venereol ; 24(8): 910-5, 2010 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-20028447

RESUMO

BACKGROUND: Standard treatment for onychomycosis often results in less than half of subjects achieving disease-free nails. Onychomycosis is even more challenging to treat as relapses and re-infections are common. OBJECTIVE: To determine if a prophylactic effect exists when a treatment with amorolfine nail lacquer (ANL), with half the frequency of the standard regimen, is instituted following successful treatment of dermatophytic toenail onychomycosis with matrix involvement. METHODS: Efficacy and safety of a group treated with ANL (once every 2 weeks) were compared with that of an untreated group in a 36-month (3 years), single-centre, randomized, open-label, comparison study. Subjects to be included in the study were required to be cured of confirmed onychomycosis with matrix involvement after an initial treatment with either ANL + oral terbinafine or oral terbinafine alone in a previous study. Prophylaxis of onychomycosis was assessed by global recurrence rate, confirmed onychomycosis, clinical recurrence and mycological recurrence. RESULTS: A total of 52 subjects were enrolled (26 in each group) in the study. Throughout the study, recurrences occurred more quickly in the untreated group compared with that in the ANL group. Statistically significant differences were observed at month 12 (ANL, 8.3%; untreated, 31.8%; P = 0.047). At endpoint, 70.8% of the subjects treated with ANL remained cured compared to 50% in the untreated group (P = 0.153). Recurrence was delayed by nearly 200 days for the ANL group compared with that of the untreated group. Amorolfine was safe and well tolerated during the study, with no treatment-related adverse events. CONCLUSION: These results suggest that amorolfine nail lacquer may be effective and is safe for use as a prophylactic treatment for the recurrence of onychomycosis.


Assuntos
Antifúngicos/uso terapêutico , Dermatoses do Pé/prevenção & controle , Laca , Morfolinas/uso terapêutico , Onicomicose/prevenção & controle , Administração Oral , Administração Tópica , Adulto , Idoso , Antifúngicos/administração & dosagem , Antifúngicos/efeitos adversos , Quimioterapia Combinada , Feminino , Dermatoses do Pé/tratamento farmacológico , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Morfolinas/administração & dosagem , Morfolinas/efeitos adversos , Naftalenos/administração & dosagem , Naftalenos/efeitos adversos , Naftalenos/uso terapêutico , Onicomicose/tratamento farmacológico , Projetos Piloto , Prevenção Secundária , Terbinafina , Resultado do Tratamento
4.
J Med Genet ; 45(5): 284-9, 2008 May.
Artigo em Inglês | MEDLINE | ID: mdl-18178632

RESUMO

BACKGROUND: Germline CDKN2A mutations have been observed in 20-40% of high risk, melanoma prone families; however, little is known about their prevalence in population based series of melanoma cases and controls. METHODS: We resequenced the CDKN2A gene, including the p14ARF variant and promoter regions, in approximately 703 registry ascertained melanoma cases and 691 population based controls from Iceland, a country in which the incidence of melanoma has increased rapidly. RESULTS: We identified a novel germline variant, G89D, that was strongly associated with increased melanoma risk and appeared to be an Icelandic founder mutation. The G89D variant was present in about 2% of Icelandic invasive cutaneous malignant melanoma cases. Relatives of affected G89D carriers were at significantly increased risk of melanoma, head and neck cancers, and pancreatic carcinoma compared to relatives of other melanoma patients. Nineteen other germline variants were identified, but none conferred an unequivocal risk of melanoma. CONCLUSIONS: This population based study of Icelandic melanoma cases and controls showed a frequency of disease related CDKN2A mutant alleles ranging from 0.7% to 1.0%, thus expanding our knowledge about the frequency of CDKN2A mutations in different populations. In contrast to North America and Australia where a broad spectrum of mutations was observed at a similar frequency, in Iceland, functional CDKN2A mutations consist of only one or two different variants. Additional genetic and/or environmental factors are likely critical for explaining the high incidence rates for melanoma in Iceland. This study adds to the geographic regions for which population based estimates of CDKN2A mutation frequencies are available.


Assuntos
Genes p16 , Mutação em Linhagem Germinativa , Melanoma/epidemiologia , Melanoma/genética , Alelos , Austrália , Estudos de Casos e Controles , Frequência do Gene , Genótipo , Humanos , Islândia/epidemiologia , América do Norte , Grupos Populacionais , Fatores de Risco
5.
J Invest Dermatol ; 80(5): 410-6, 1983 May.
Artigo em Inglês | MEDLINE | ID: mdl-6841997

RESUMO

The urinary excretion of histamine and its main metabolite, 1-methyl-4-imidazoleacetic acid (MeImAA), was determined in 30 adult patients with the clinical diagnosis of urticaria pigmentosa (UP). Clinical and laboratory investigations including skin histology, bone marrow examination, and scintigraphy of the skeleton, liver, and spleen revealed systemic manifestations in 14 cases. Among the 16 cases with dermal proliferation of mast cells only 3 cases classified as telangiectasia macularis eruptiva perstans (TMEP). All patients with systemic mastocytosis and UP excreted increased amounts of MeImAA in the urine while normal amounts were found in 2 of the patients with TMEP. A significant correlation existed between MeImAA excretion and the extent of mast cell infiltration in skin and internal organs. No such correlation was found for urinary histamine. Urinary MeImAA but not histamine is therefore considered a useful indicator of systemic involvement by reflecting the size of the mast cell histamine pool. The main symptom of the patients was pruritus, which was moderate to severe in 17 and mild or absent in 13 cases. Gastrointestinal symptoms were present in 14 patients. However, there was no obvious correlation between the excretion of MeImAA and any of the symptoms recorded. Neither was the severity of pruritus correlated to the histamine content of the skin, which was measured in both lesional and unaffected skin in 23 of the patients. Thus, symptoms possibly caused by histamine in mastocytosis patients are not directly related to urinary histamine metabolite excretion or tissue histamine content.


Assuntos
Histamina/metabolismo , Urticaria Pigmentosa/metabolismo , Adulto , Idoso , Feminino , Histamina/análise , Histamina/urina , Humanos , Imidazóis/urina , Masculino , Mastócitos/metabolismo , Pessoa de Meia-Idade , Prurido/metabolismo , Pele/análise
6.
Diagn Microbiol Infect Dis ; 18(2): 101-4, 1994 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-8062526

RESUMO

A fully automated enzyme-linked fluorescent assay (ELFA) on the Vitek Immunodiagnostic Assay System (VIDAS CHL) was evaluated for the detection of chlamydial antigen in specimens from symptomatic and asymptomatic high-risk patients. The results were compared with those from McCoy cell culture and Chlamydiazyme with a blocking assay. False-positive VIDAS specimens were centrifuged and the pellet stained with direct fluorescent antibody (DFA). Of the 158 urine specimens, 52 (33%) were infected by Chlamydia trachomatis. The sensitivity and specificity of the VIDAS when compared with cell culture, DFA, and Chlamydiazyme were 75% and 96%, respectively, for urine specimens while the predictive value of a positive (PVP) and a negative (PVN) were 91% and 88%, respectively. Of the 245 urethral swabs, 75 (31%) were considered positive. The sensitivity and specificity were 71% and 92%, respectively, and the PVP and PVN were 80% and 87%, respectively. The sensitivity and specificity on the 108 cervical swabs, 22 of which were positive, were 95% and 95%, respectively, and PVP and PVN were 88% and 99%, respectively. Compared with Chlamydiazyme, the VIDAS was more sensitive on specimens from female patients and urine specimens, but less sensitive on urethral specimens from male patients.


Assuntos
Antígenos de Bactérias/análise , Infecções por Chlamydia/diagnóstico , Chlamydia trachomatis/imunologia , Imunofluorescência , Adolescente , Adulto , Automação , Infecções por Chlamydia/epidemiologia , Infecções por Chlamydia/microbiologia , Estudos de Avaliação como Assunto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Risco
7.
Arch Dermatol ; 122(4): 422-7, 1986 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-3954410

RESUMO

The bone marrow sections from five normal subjects and 18 patients with mastocytosis were examined to establish criteria to distinguish urticaria pigmentosa from systemic mastocytosis. Nine patients had increased numbers of mast cells in bone marrow sections stained with a long toluidine blue staining technique specific for mast cells, whereas five patients exhibited increased numbers of mast cells on May-Grünwald-Giemsa-stained smears of bone marrow. A positive correlation between the number of mast cells in sections of the bone marrow and the urinary excretion of the main histamine metabolite tele-methylimidazoleacetic acid was found. In ten of the examined bone marrow specimens, focal lesions containing mast cells, lymphocytes, and eosinophils appeared. The presence of these focal lesions together with either an increased number of mast cells in bone marrow sections and/or increased urinary excretion of telemethylimidazoleacetic acid is considered diagnostic of systemic mastocytosis. No patient exhibited myeloproliferative condition or other major hematologic abnormality.


Assuntos
Medula Óssea/patologia , Imidazóis/urina , Mastócitos/patologia , Urticaria Pigmentosa/patologia , Adulto , Idoso , Animais , Biópsia , Biópsia por Agulha , Contagem de Células Sanguíneas , Contagem de Células , Feminino , Hemoglobinas , Humanos , Masculino , Camundongos , Pessoa de Meia-Idade , Reticulina/metabolismo , Pele/patologia , Fatores de Tempo
8.
Arch Dermatol Res ; 278(3): 228-31, 1986.
Artigo em Inglês | MEDLINE | ID: mdl-2425755

RESUMO

Chronic urticaria is a disease for which the available range of treatment modalities is limited. Ultraviolet radiation has recently been shown to affect histamine release from mast cells. We therefore studied the effects of PUVA and UVA on chronic urticaria. Nineteen patients took part in the study, which was designed as a randomized double-blind study. Eleven patients received PUVA, and 8 received UVA plus a placebo. In the PUVA group, 7 patients showed improvement, 3 noticed no change, and 1 became worse. In the group that received UVA plus placebo, 5 patients experienced an improvement, whereas the other 3 showed no change. The differences between the groups were not statistically significant. However, the probability of achieving this degree of improvement in both groups just by chance is less than 1%. Consequently, the improvement noted could have been due to either UVA alone or a placebo effect. It is concluded that PUVA is not better than UVA in the treatment of chronic urticaria.


Assuntos
Terapia PUVA , Terapia Ultravioleta , Urticária/terapia , Adulto , Idoso , Doença Crônica , Ensaios Clínicos como Assunto , Método Duplo-Cego , Feminino , Liberação de Histamina/efeitos da radiação , Humanos , Imidazóis/urina , Masculino , Pessoa de Meia-Idade , Urticária/tratamento farmacológico , Urticária/radioterapia
9.
Artigo em Inglês | MEDLINE | ID: mdl-3901645

RESUMO

At the Department of Dermatology, Sahlgrenska sjukhuset, Göteborg, 58 patients with mastocytosis were investigated during the years 1979-1984. The purpose of this study was to examine the extent of the disease, the degree of mast cell infiltration in skin and bone marrow, to evaluate the most frequently used diagnostic methods, to study some immunological functions and genetic markers, to determine the histamine metabolism and to test a new drug which inhibits histidine decarboxylation. Besides a clinical examination, skin biopsies were taken from involved and uninvolved skin. The biopsies were fixed in 4% neutral formaldehyde or in an iso-osmotic mixture of 0.6% formaldehyde and 0.5% acetic acid (IFAA) and stained with toluidine blue 30 minutes or 5 days. The mast cell density in the formaldehyde fixed biopsies stained 5 days was significantly higher than the routine short stained biopsies. The same results were obtained with IFAA fixation and short toluidine stain. This might be caused by aldehyde blocking of dye-binding groups, which has been observed earlier in mucosal mast cells. Sternal aspirate and crista iliaca biopsies were done in order to examine the bone marrow. When comparing these two methods, the bone-marrow biopsy was found to be more reliable and sensitive when judging the mast cell increase. This resulted in more systemic mastocytosis patients being detected through crista biopsy than through sternal aspirate. Lesions with mast cells, eosinophils and lymphocytes were seen in the biopsies. These lesions may be an early sign of a systemic involvement of the disease. The urinary tele-methylimidazoleacetic acid (MeImAA) excretion was increased in most of the patients, and was found to correlate with the extent of the disease, both concerning organs involved and the mast cell numbers in the bone marrow. A lymphocyte stimulation with Concanavalin-A (Con-A) and phytohaemagglutinin (PHA) showed a decreased mitogenic response, especially in the patients with the highest histamine turnover. Inhibition was also seen when histamine was added to mitogen stimulated lymphocytes from healthy controls, while only a minimal inhibition of the mitogen response was obtained by histamine metabolites. Even if histamine in vitro seems to affect the lymphocyte mitogenic response, and the lymphocyte stimulation in the patients was inhibited, this does not seem to have any obvious clinical relevance. HLA-typing was carried out on 50 patients but no phenotypic aberrations were detected. Lymphocytes from patients with HLA-B12 seemed to react with the same mitogenic inhibition as those from other patients.(ABSTRACT TRUNCATED AT 400 WORDS)


Assuntos
Urticaria Pigmentosa/patologia , Adulto , Idoso , Medula Óssea/patologia , Feminino , Antígenos HLA/análise , Histamina/metabolismo , Histidina Descarboxilase/antagonistas & inibidores , Humanos , Hipersensibilidade/complicações , Imidazóis/urina , Ativação Linfocitária , Linfócitos/imunologia , Masculino , Mastócitos/patologia , Metilistidinas/uso terapêutico , Pessoa de Meia-Idade , Pele/patologia , Urticaria Pigmentosa/tratamento farmacológico , Urticaria Pigmentosa/fisiopatologia
10.
Pharmazie ; 52(6): 463-5, 1997 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-9260268

RESUMO

A mixture of glycerol monoethers was extracted from the liver oil of deep sea shark (Centroporus squamosus). It consisted mainly of monoethers of glycerol and linear monounsaturated octadecanol, and glycerol and linear monounsaturated hexadecanol. Only about 11% of the extract consisted of glycerol monoethers derived from linear saturated fatty alcohols. The glycerol monoether extract was somewhat less effective as skin penetration enhancer than oleic acid and other potent fatty acid penetration enhancers, but it was still a very effective enhancer in the hairless mouse skin model used in this study.


Assuntos
Excipientes/síntese química , Éteres de Glicerila/isolamento & purificação , Éteres de Glicerila/farmacologia , Tubarões/metabolismo , Absorção Cutânea/efeitos dos fármacos , Animais , Anti-Inflamatórios/farmacocinética , Estradiol/farmacocinética , Excipientes/farmacologia , Feminino , Óleos de Peixe/química , Óleos de Peixe/farmacologia , Hidrocortisona/farmacocinética , Camundongos , Camundongos Pelados , Nitroglicerina/farmacocinética , Estimulação Química , Vasodilatadores/farmacocinética
11.
Boll Chim Farm ; 136(10): 640-5, 1997 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-9528172

RESUMO

The effects of several marine lipids on the penetration of hydrocortisone and nitroglycerin through excised hairless mouse skin have been studied. Fatty acid extracts obtained by hydrolysis of Portuguese dog-fish-liver-oil or by hydrolysis of cod-liver-oil were shown to be effective skin penetration enhancers. Phospholipid obtained from squid was also shown to be effective enhancer. However, the enhancing effect of the marine products could generally be associated with their content of free unsaturated fatty acids. The fatty acid extract obtained from cod-liver-oil caused insignificant skin irritation when incorporated into an ointment base and applied to human skin.


Assuntos
Óleos de Peixe/farmacologia , Absorção Cutânea/efeitos dos fármacos , Administração Cutânea , Administração Tópica , Adulto , Animais , Anti-Inflamatórios/administração & dosagem , Anti-Inflamatórios/farmacocinética , Cromatografia Líquida de Alta Pressão , Óleos de Peixe/toxicidade , Humanos , Hidrocortisona , Irritantes/toxicidade , Camundongos , Camundongos Pelados , Pessoa de Meia-Idade , Pomadas , Espectrofotometria Ultravioleta
13.
J Clin Microbiol ; 44(3): 1139-40, 2006 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-16517914

RESUMO

A simple Gram stain evaluation for the diagnosis of bacterial vaginosis was assessed in comparison to Nugent's method. The sensitivity (90%), specificity (94%), positive and negative predictive values (90% and 94%), and good interobserver agreement obtained indicate that the test method can be performed reliably in the routine clinical microbiology laboratory.


Assuntos
Técnicas Bacteriológicas/métodos , Vaginose Bacteriana/diagnóstico , Adolescente , Adulto , Técnicas Bacteriológicas/estatística & dados numéricos , Feminino , Violeta Genciana , Humanos , Pessoa de Meia-Idade , Fenazinas , Valor Preditivo dos Testes , Sensibilidade e Especificidade , Coloração e Rotulagem/métodos , Coloração e Rotulagem/estatística & dados numéricos , Vaginose Bacteriana/microbiologia
14.
Int Arch Allergy Appl Immunol ; 77(4): 423-9, 1985.
Artigo em Inglês | MEDLINE | ID: mdl-3874830

RESUMO

Immunological functions were studied in 22 patients with mastocytosis. Lymphocyte stimulation with concanavalin A (Con A) and phytohemagglutinin showed that the patients responded with lower mitogenic activity than healthy controls. Furthermore, the lymphocytes of patients with the most extensive mast cell disease had a significantly lower Con A mitogen response than the lymphocytes of the rest of the patients. The effect of histamine and its specific metabolites, tele-methylhistamine and tele-methylimidazoleacetic acid (MeImAA), on the Con A lymphocyte mitogen response was also studied in healthy controls. Histamine had a clear suppressive effect, while the metabolite tele-methylhistamine caused only slight inhibition and MeImAA apparently had no effect. The total T cell, suppressor and helper cell numbers, measured with monoclonal antibodies, and the amount of immunoglobulins in serum were found to be normal.


Assuntos
Ativação Linfocitária , Mitógenos/farmacologia , Linfócitos T/imunologia , Urticaria Pigmentosa/imunologia , Adulto , Idoso , Concanavalina A/farmacologia , Feminino , Histamina/metabolismo , Histamina/farmacologia , Humanos , Imidazóis/farmacologia , Técnicas In Vitro , Ativação Linfocitária/efeitos dos fármacos , Masculino , Metilistaminas/farmacologia , Pessoa de Meia-Idade , Fito-Hemaglutininas/farmacologia , Urticaria Pigmentosa/metabolismo
15.
Int Arch Allergy Appl Immunol ; 77(4): 430-2, 1985.
Artigo em Inglês | MEDLINE | ID: mdl-4018885

RESUMO

HLA-ABC and DR typing was performed on 50 patients with mastocytosis. Lymphocyte stimulation with concanavalin A has earlier been performed in 22 of these patients. No phenotypic aberrations were detected in the patient group. 8 patients had the HLA-B12 phenotype. Lymphocytes from the HLA-B12 phenotype stimulated with a lymphocyte mitogen have earlier been shown to react with decreased inhibitory effect to histamine. 2 patients in this study had the HLA-B12 phenotype and systemic mastocytosis with high histamine turnover, but these patients reacted with a low mitogen response of the lymphocytes.


Assuntos
Antígenos HLA/imunologia , Antígenos HLA-B , Histamina/farmacologia , Linfócitos/efeitos dos fármacos , Urticaria Pigmentosa/imunologia , Adulto , Idoso , Concanavalina A/farmacologia , Feminino , Histamina/metabolismo , Humanos , Técnicas In Vitro , Ativação Linfocitária/efeitos dos fármacos , Linfócitos/imunologia , Masculino , Pessoa de Meia-Idade , Urticaria Pigmentosa/metabolismo
16.
Agents Actions ; 16(3-4): 244-8, 1985 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-4013913

RESUMO

Alpha-fluoromethylhistidine, alpha-FMH (L-641.575, Merck, Sharp and Dohme), a specific irreversible inhibitor of the mammalian histidine decarboxylase, was investigated for its effect on possible histamine symptoms in mastocytosis. Two patients were treated for 28 and 22 weeks respectively. The first patient had systemic mastocytosis and a severe malabsorption causing weight loss, excessive fecal fat losses and electrolyte disturbances, the main symptom being frequent diarrhoea. The second patient had mainly skin manifestations diagnosed as urticaria pigmentosa and the main symptom was pruritus. There were no side effects of the drug. The first patient produced formed stools after one week of treatment, concomitant with a decrease in plasma histamine and in urinary excretion of the main histamine metabolite tele-methylimidazoleacetic acid (MeImAA). In the second patient definite benefit of the treatment was observed after two months. However, changes in histamine parameters occurred earlier. Plasma histamine and urinary MeImAA were reduced after one week and in two or three weeks reached a steady-state level of about 25% of pretreatment values. The results indicate an effective inhibition of histamine synthesis in both patients but only the diarrhoea seemed to be causally related to the change in histamine metabolism.


Assuntos
Carboxiliases/antagonistas & inibidores , Histidina Descarboxilase/antagonistas & inibidores , Histidina/análogos & derivados , Metilistidinas/uso terapêutico , Urticaria Pigmentosa/tratamento farmacológico , Idoso , Feminino , Histamina/metabolismo , Humanos , Pessoa de Meia-Idade , Urticaria Pigmentosa/metabolismo
17.
Acta Derm Venereol ; 66(1): 16-22, 1986.
Artigo em Inglês | MEDLINE | ID: mdl-2424209

RESUMO

The mast cell distribution and number were studied in skin biopsies of 18 mastocytosis patients and 10 controls. The biopsies were stained for mast cells with toluidine blue at pH 0.5. The number in the upper dermis of lesional abdominal skin was at least twice as high as that of normal adjacent skin. Fixation in iso-osmotic 0.6% formaldehyde and 0.5% acetic acid, revealed more mast cells than conventional 4% formaldehyde fixation. Staining for 5 days, when compared to the normal for 30 min, increased the number of demonstrable mast cells just as did the change in fixation. Conventional formaldehyde fixation thus partially blocks the dye-binding of cutaneous mast cells, about 20% of the cells escaping detection. The degree of aldehyde blocking was similar in lesional and normal skin. A more pronounced blocking of dye-binding has been demonstrated previously in gut mucosal mast cells. Whether the blocking of dye-binding is an expression of heterogeneity in dermal mast cells remains to be determined.


Assuntos
Mastócitos/patologia , Pele/patologia , Urticaria Pigmentosa/patologia , Adolescente , Adulto , Idoso , Biópsia , Contagem de Células , Feminino , Fixadores , Formaldeído , Humanos , Concentração de Íons de Hidrogênio , Masculino , Mastócitos/análise , Pessoa de Meia-Idade , Coloração e Rotulagem , Cloreto de Tolônio , Urticaria Pigmentosa/diagnóstico
18.
Laeknabladid ; 83(12): 831-3, 1997 Dec.
Artigo em Is | MEDLINE | ID: mdl-19679922

RESUMO

Cutaneous leishmaniasis is a common infection in South America and the Middle East. A 20 year Icelander was infected with leishmaniasis while travelling in South America. Treatment with the antimonial sodium stibogluconate was successful. With increased travelling to tropical and subtropical countries a rising incidence of tropical infectious diseases can be expected in Iceland.

19.
Laeknabladid ; 83(1): 30-4, 1997 Jan.
Artigo em Is | MEDLINE | ID: mdl-19679931

RESUMO

Cheyletiella mites (Acarina) are ectoparasites that infest cats, dogs and rabbits in many countries of the world. Upon contact with infested animals the mites may temporarily produce grouped, erythematous macules on the skin of humans which rapidly develop a central, vesicular papule. These signs are most often found on the arms and the trunk. Recently these typical signs were observed on the skin of the members of two different Icelandic families which both kept a Persian cat. An examination for ectoparasites on the cats revealed that both were infested by Cheyletiellaparasitovorax. It is unknown how and when the parasite was transmitted to Iceland.

20.
Acta Derm Venereol ; 76(3): 228-30, 1996 May.
Artigo em Inglês | MEDLINE | ID: mdl-8800306

RESUMO

We have compared bathing in a thermal lagoon in Iceland, combined with UVB treatment, to UVB treatment only in an open comparative study. Twenty-three psoriasis patients bathed 3 times daily and were treated with UVB 5 times a week for 4 weeks. The control group was only treated with UVB 5 times a week for 4 weeks. Psoriasis Area and Severity Index (PSAI) was used to estimate the severity of the disease. The mean PASI score in the bathing group decreased from 20.8 to 2.8 (p < 0.01). In the control UVB group, the PASI score decreased from 16. 7 to 6.9. The percentage difference between the groups was significant after 1, 2, 2 and 4 weeks. Bathing in the lagoon combined with UVB was found to be a very effective treatment and better than UVB treatment in our control group.


Assuntos
Balneologia , Psoríase/terapia , Terapia Ultravioleta , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Terapia Combinada , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
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