Transport of radioactive ion beams and related safety issues: the 132Sn+ case study.

The transport of intense radioactive ion beam currents requires a careful design in order to limit the beam losses, the contamination and thus the dose rates. Some investigations based on numerical models and calculations have been performed in the framework of the SPIRAL 2 project to evaluate the performance of a low energy beam transport line located between the isotope separation on line (ISOL) production cell and the experiment areas. The paper presents the results of the transverse phase-space analysis, the beam losses assessment, the resulting contamination, and radioactivity levels. They show that reasonable beam transmission, emittance growth, and dose rates can be achieved considering the current standards.

[The so-called "benign gonoccocal sepsis"]. / Beitrag zur Kenntnis das sogenannten "benignen Gonokokken-Sepsis"

Five female patients with benign gonococcal sepsis were seen during the second half of 1974. All cases presented the typical clinical triad of fever, arthralgias and characteristic skin lesions, the macroscopic and microscopic appearance of which could be best classified as superficial vasculitis. Skin biopsies were taken from 3 patients and the histopathological findings are discussed in detail. Genital symptoms were slight or absent, and only very few gonococci could be detected in stained smears from genital sites. However, Neisseria gonorrhoeae could be cultured without difficulty from the genitourinary tract in all cases, while cultures from blood and skin lesions were sterile. In fresh pustules gonococci could be demonstrated by immunofluorescence in 2 cases. The complement-fixation-test is regarded as a useful supplementary diagnostic procedure.

[Inhibition of propionibacteria in the sebaceous gland duct using photochemotherapy and 8-methoxypsoralen]. / Uber die Hemmung der Propionibakterien im Talgdrüseninfundibulum durch Photochemotherapie mit 8-Methoxypsoralen.

It was shown by in vitro studies that 8-methoxypsoralen (= 8 MOP) alone and UVA irradiation alone produces relatively little inhibition of the growth of Propionibacterium acnes and Propionibacterium granulosum, whereas a combination leads to an intense suppression of bacterial growth. It was further demonstrated by in vivo studies on 14 subjects that local treatment with 8 MOP and UVA significantly reduces the propionibacteria in the pilosebaceous duct. These results afford a possible explanation for the well known favorable effect of photochemotherapy on acne vulgaris. In addition, they contribute to explaining the drier appearance of the skin after photochemotherapy.

[Studies on the prenatally toxic effect of parathionemethyl in Wistar rats compared to cyclophosphamide and trypan blue]. / Untersuchungen zur pränatal-toxischen Wirkung von Parathion-methyl an Wistarratten im Vergleich zu Cyclophosphamid und Trypanblau

Higher yield and performance in plant and animal production will depend on reinforced use of pesticides, particularly alkyl phosphate esters and insecticidal carbamates. Prenatal toxic action of the pesticides used today may be detrimental to human and animal health. Prenatal-toxicological tests, using parathion-methyl, were conducted on the basis of known but modified experimental methods. The vulnerability of a rat strain was tested by applying to it teratogenic model substances (trypan blue and cyclophosphamide). Several oral applications of parathion-methyl (3 ppm) during the sensitive phases of germ formation and growth (fifth to ninth and eleventh to fifteenth or eleventh to nineteenth days from conception) were followed by clear embryotoxic effects, such as retardation and increased resorption. The average number of resorption sites grew from nine in the control group to 20 in the experimental group. Postnatal malformations were not observed.

On the influence of X-ray irradiation and photochemotherapy with 8-methoxypsoralen on the sebaceous gland of the Syrian hamster ear.

30 male Syrian hamsters were X-ray irradiated on 1 ear with 500 rad (Dermopan 2; setting 3; tissue half value thickness, 7.5 mm). 30 other animals were treated locally on one ear with an emulsion containing 0.15% 8-methoxypsoralen and then with UV A (10 treatments in 23 days; total UV A dose, 5.0 J/cm20. The other ear served as control. An in vivo double-labelling autoradiography with 3H- and 14C-thymidine was carried out on half of the animals of each group. The other half was administered 3H-thymidine and the number of labelled cells still in contact with the basal lamina of the sebaceous gland after 6 days was determined. The effects of X-ray irradiation and photochemotherapy are identical. Cell proliferation in the sebaceous gland was reduced, the length of the S phase was shortened, and the number of marked cells still in contact with the basal lamina after 6 days was decreased.