Detalhe da pesquisa
1.
The design and synthesis of novel spirocyclic heterocyclic sulfone ROMK inhibitors as diuretics.
Bioorg Med Chem Lett
; 27(4): 1109-1114, 2017 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28111141
2.
Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores.
Bioorg Med Chem Lett
; 27(11): 2559-2566, 2017 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28431879
3.
The Renal Outer Medullary Potassium Channel Inhibitor, MK-7145, Lowers Blood Pressure, and Manifests Features of Bartter's Syndrome Type II Phenotype.
J Pharmacol Exp Ther
; 359(1): 194-206, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27432892
4.
Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation.
Bioorg Med Chem Lett
; 26(9): 2339-43, 2016 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27017115
5.
Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold.
Bioorg Med Chem Lett
; 26(23): 5695-5702, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27839686
6.
Evaluation of cynomolgus monkeys for the identification of endogenous biomarkers for hepatic transporter inhibition and as a translatable model to predict pharmacokinetic interactions with statins in humans.
Drug Metab Dispos
; 43(6): 851-63, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25813937
7.
Pharmacologic inhibition of the renal outer medullary potassium channel causes diuresis and natriuresis in the absence of kaliuresis.
J Pharmacol Exp Ther
; 348(1): 153-64, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24142912
8.
Discovery of a novel sub-class of ROMK channel inhibitors typified by 5-(2-(4-(2-(4-(1H-Tetrazol-1-yl)phenyl)acetyl)piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one.
Bioorg Med Chem Lett
; 23(21): 5829-32, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24075732
9.
The role of the therapeutic alliance in the regulation of emotion in psychosis: an attachment perspective.
Clin Psychol Psychother
; 20(6): 523-30, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-22570312
10.
Characterization of multidrug resistance 1a/P-glycoprotein knockout rats generated by zinc finger nucleases.
Mol Pharmacol
; 81(2): 220-7, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22049154
11.
Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities.
Bioorg Med Chem Lett
; 20(20): 6088-92, 2010 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20832306
12.
Extending the Reach of Pediatric Emergency Preparedness: A Virtual Tabletop Exercise Targeting Children's Needs.
Public Health Rep
; 134(4): 344-353, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31095469
13.
Medical Countermeasures for Children in Radiation and Nuclear Disasters: Current Capabilities and Key Gaps.
Disaster Med Public Health Prep
; 13(3): 639-646, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30387408
14.
Discovery of N-{(1S,2S)-2-(3-cyanophenyl)- 3-[4-(2-[18F]fluoroethoxy)phenyl]-1-methylpropyl}- 2-methyl-2-[(5-methylpyridin-2-yl)oxy]propanamide, a cannabinoid-1 receptor positron emission tomography tracer suitable for clinical use.
J Med Chem
; 50(15): 3427-30, 2007 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-17608398
15.
Differential anti-thrombotic benefit and bleeding risk profiles of antagonists of protease-activated receptor 1 and 4 in Cynomolgus Macaques.
Thromb Res
; 145: 133-9, 2016 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-27318768
16.
Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure.
ACS Med Chem Lett
; 7(7): 697-701, 2016 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27437080
17.
Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation.
ACS Med Chem Lett
; 6(7): 747-52, 2015 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26191360
18.
Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics.
ACS Med Chem Lett
; 3(5): 367-72, 2012 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900480
19.
Chemical genetics define the roles of p38alpha and p38beta in acute and chronic inflammation.
J Biol Chem
; 282(48): 34663-71, 2007 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-17855341
20.
Enhanced external counterpulsation treatment improves arterial wall properties and wave reflection characteristics in patients with refractory angina.
J Am Coll Cardiol
; 48(6): 1208-14, 2006 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-16979007