Detalhe da pesquisa
1.
Resistance outside the substrate envelope: hepatitis C NS3/4A protease inhibitors.
Crit Rev Biochem Mol Biol
; 54(1): 11-26, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30821513
2.
Structural basis and distal effects of Gag substrate coevolution in drug resistance to HIV-1 protease.
Proc Natl Acad Sci U S A
; 111(45): 15993-8, 2014 Nov 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25355911
3.
HIV-1 protease-substrate coevolution in nelfinavir resistance.
J Virol
; 88(13): 7145-54, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24719428
4.
The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors.
PLoS Pathog
; 8(7): e1002832, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22910833
5.
The pan-RAF-MEK non degrading molecular glue NST-628 is a potent and brain penetrant inhibitor of the RAS-MAPK pathway with activity across diverse RAS- and RAF-driven cancers.
Cancer Discov
; 2024 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38588399
6.
Context surrounding processing sites is crucial in determining cleavage rate of a subset of processing sites in HIV-1 Gag and Gag-Pro-Pol polyprotein precursors by viral protease.
J Biol Chem
; 287(16): 13279-90, 2012 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22334652
7.
Discovery of BLU-945, a Reversible, Potent, and Wild-Type-Sparing Next-Generation EGFR Mutant Inhibitor for Treatment-Resistant Non-Small-Cell Lung Cancer.
J Med Chem
; 65(14): 9662-9677, 2022 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35838760
8.
Evaluating the substrate-envelope hypothesis: structural analysis of novel HIV-1 protease inhibitors designed to be robust against drug resistance.
J Virol
; 84(10): 5368-78, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20237088
9.
Machine learning integration for predicting the effect of single amino acid substitutions on protein stability.
BMC Struct Biol
; 9: 66, 2009 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-19840377
10.
Selectively Modulating Conformational States of USP7 Catalytic Domain for Activation.
Structure
; 26(1): 72-84.e7, 2018 01 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29249604
11.
Clusters of isoleucine, leucine, and valine side chains define cores of stability in high-energy states of globular proteins: Sequence determinants of structure and stability.
Protein Sci
; 25(3): 662-75, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26660714
12.
Molecular Basis for Differential Patterns of Drug Resistance in Influenza N1 and N2 Neuraminidase.
J Chem Theory Comput
; 12(12): 6098-6108, 2016 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27951676
13.
Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2.
Cancer Cell
; 29(4): 477-493, 2016 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26996308
14.
Drug-resistant HIV-1 protease regains functional dynamics through cleavage site coevolution.
Evol Appl
; 8(2): 185-98, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25685193
15.
Improving the Resistance Profile of Hepatitis C NS3/4A Inhibitors: Dynamic Substrate Envelope Guided Design.
J Chem Theory Comput
; 9(12): 5693-5705, 2013 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24587770
16.
Evaluating the role of macrocycles in the susceptibility of hepatitis C virus NS3/4A protease inhibitors to drug resistance.
ACS Chem Biol
; 8(7): 1469-78, 2013 Jul 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-23594083
17.
HIV-1 Protease and Substrate Coevolution Validates the Substrate Envelope As the Substrate Recognition Pattern.
J Chem Theory Comput
; 8(2)2012 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24348205
18.
Extreme entropy-enthalpy compensation in a drug-resistant variant of HIV-1 protease.
ACS Chem Biol
; 7(9): 1536-46, 2012 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22712830
19.
Dynamics of preferential substrate recognition in HIV-1 protease: redefining the substrate envelope.
J Mol Biol
; 410(4): 726-44, 2011 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-21762811
20.
Molecular Basis for Drug Resistance in HIV-1 Protease.
Viruses
; 2(11): 2509-2535, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21994628