Detalhe da pesquisa
1.
Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro Cytochrome P450 Induction Studies Including Impact on Drug Interaction Risk Assessment.
Drug Metab Dispos
; 49(1): 94-110, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33139460
2.
In Vitro Evaluation of the Drug Interaction Potential of Doravirine.
Antimicrob Agents Chemother
; 63(4)2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30745395
3.
Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Focus on Downregulation, CYP2C Induction, and CYP2B6 Positive Control.
Drug Metab Dispos
; 45(10): 1049-1059, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28646080
4.
Evaluation of CYP2B6 Induction and Prediction of Clinical Drug-Drug Interactions: Considerations from the IQ Consortium Induction Working Group-An Industry Perspective.
Drug Metab Dispos
; 44(10): 1720-30, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27422672
5.
Evaluation of cynomolgus monkeys for the identification of endogenous biomarkers for hepatic transporter inhibition and as a translatable model to predict pharmacokinetic interactions with statins in humans.
Drug Metab Dispos
; 43(6): 851-63, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25813937
6.
Pharmacological evaluation of selective α2c-adrenergic agonists in experimental animal models of nasal congestion.
J Pharmacol Exp Ther
; 349(1): 75-84, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24492651
7.
Distribution, Metabolism, and Excretion of Cenobamate in Adult, Fetal, Neonatal, and Lactating Rats.
Eur J Drug Metab Pharmacokinet
; 49(1): 7-21, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37921950
8.
In vitro assessment of drug-drug interaction potential of boceprevir associated with drug metabolizing enzymes and transporters.
Drug Metab Dispos
; 41(3): 668-81, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23293300
9.
Substituted imidazole of 5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine Inactivates cytochrome P450 2D6 by protein adduction.
Drug Metab Dispos
; 39(6): 974-83, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21422192
10.
Application of a Rat Liver Drug Bioactivation Transcriptional Response Assay Early in Drug Development That Informs Chemically Reactive Metabolite Formation and Potential for Drug-induced Liver Injury.
Toxicol Sci
; 177(1): 281-299, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32559301
11.
Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activity.
J Med Chem
; 51(11): 3061-4, 2008 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-18447380
12.
Temporal evaluation of CYP mRNA in mice administered with prototypical P450 inducers: comparison with conventional protein/enzyme methods.
Drug Chem Toxicol
; 31(4): 501-13, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18850359
13.
Overcoming Time-Dependent Inhibition (TDI) of Cytochrome P450 3A4 (CYP3A4) Resulting from Bioactivation of a Fluoropyrimidine Moiety.
J Med Chem
; 61(23): 10700-10708, 2018 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30388368
14.
Heterotricyclic himbacine analogs as potent, orally active thrombin receptor (protease activated receptor-1) antagonists.
J Med Chem
; 50(21): 5147-60, 2007 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-17854166
15.
Metabolism-based identification of a potent thrombin receptor antagonist.
J Med Chem
; 50(1): 129-38, 2007 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-17201416
16.
Quantitative PCR assay for cytochromes P450 2B and 3A induction in rat precision-cut liver slices: correlation study with induction in vivo.
J Pharmacol Toxicol Methods
; 52(2): 234-43, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-16125621
17.
A high-throughput cell-based reporter gene system for measurement of CYP1A1 induction.
J Pharmacol Toxicol Methods
; 47(3): 143-51, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-12628305
18.
Prednisone has no effect on the pharmacokinetics of CYP3A4 metabolized drugs - midazolam and odanacatib.
J Clin Pharmacol
; 54(11): 1280-9, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24895078
19.
Pharmacokinetics of pseudoephedrine in rats, dogs, monkeys and its pharmacokinetic-pharmacodynamic relationship in a feline model of nasal congestion.
Drug Metab Lett
; 4(2): 56-61, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20446910
20.
High-throughput evaluation of CYP1A1 and 2B1 induction in rat liver slices using a semi-automated system.
Drug Metab Lett
; 3(2): 108-14, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19601872