Detalhe da pesquisa
1.
Multi-step parallel synthesis enabled optimization of benzofuran derivatives as pan-genotypic non-nucleoside inhibitors of HCV NS5B.
Bioorg Med Chem Lett
; 30(7): 127004, 2020 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32061500
2.
Design and evaluation of novel tetracyclic benzofurans as palm site allosteric inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett
; 29(24): 126104, 2019 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30389294
3.
The synthesis of 2,3,6-trisubstituted 1-oxo-1,2-dihydroisoquinolines as potent CRTh2 antagonists.
Bioorg Med Chem Lett
; 27(23): 5344-5348, 2017 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29110986
4.
Discovery of a novel series of potent MK2 non-ATP competitive inhibitors using 1,2-substituted azoles as cis-amide isosteres.
Bioorg Med Chem Lett
; 24(15): 3609-13, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24913714
5.
Quality by design (QbD) of amide isosteres: 5,5-Disubstituted isoxazolines as potent CRTh2 antagonists with favorable pharmacokinetic and drug-like properties.
Bioorg Med Chem Lett
; 24(6): 1615-20, 2014 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24556380
6.
Ligand-dependent site-selective Suzuki cross-coupling of 3,5-dichloropyridazines.
J Org Chem
; 78(15): 7758-63, 2013 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-23848481
7.
Conformation constraint of anilides enabling the discovery of tricyclic lactams as potent MK2 non-ATP competitive inhibitors.
Bioorg Med Chem Lett
; 23(11): 3262-6, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23602398
8.
The discovery of fused oxadiazepines as gamma secretase modulators for treatment of Alzheimer's disease.
Bioorg Med Chem Lett
; 23(2): 466-71, 2013 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23253441
9.
Facile synthesis of tetracyclic azepine and oxazocine derivatives and their potential as MAPKAP-K2 (MK2) inhibitors.
Bioorg Med Chem Lett
; 22(2): 1068-72, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22182499
10.
Synthesis and structure-activity relationship (SAR) study of 4-azabenzoxazole analogues as H3 antagonists.
Bioorg Med Chem Lett
; 22(5): 2075-8, 2012 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22326166
11.
A three-step protocol for lead optimization: quick identification of key conformational features and functional groups in the SAR studies of non-ATP competitive MK2 (MAPKAPK2) inhibitors.
Bioorg Med Chem Lett
; 22(1): 65-70, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22169260
12.
Fused bicycles as arylketone bioisosteres leading to potent, orally active thiadiazole H3 antagonists.
Bioorg Med Chem Lett
; 22(9): 3354-7, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22464130
13.
SAR studies of C2 ethers of 2H-pyrano[2,3-d]pyrimidine-2,4,7(1H,3H)-triones as nicotinic acid receptor (NAR) agonist.
Bioorg Med Chem Lett
; 22(2): 854-8, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22209457
14.
Discovery of Insulin/GLP-1/Glucagon Triagonists for the Treatment of Diabetes and Obesity.
ACS Med Chem Lett
; 13(8): 1255-1261, 2022 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35978702
15.
Discovery of MK-1462: GLP-1 and Glucagon Receptor Dual Agonist for the Treatment of Obesity and Diabetes.
ACS Med Chem Lett
; 13(8): 1248-1254, 2022 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35978682
16.
Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Nav1.7 for the Treatment of Pain.
J Med Chem
; 65(1): 485-496, 2022 01 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34931831
17.
Discovery of fused 5,6-bicyclic heterocycles as γ-secretase modulators.
Bioorg Med Chem Lett
; 21(2): 664-9, 2011 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21195610
18.
Discovery of a series of potent arylthiadiazole H(3) antagonists.
Bioorg Med Chem Lett
; 21(2): 861-4, 2011 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21186123
19.
Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors.
ACS Med Chem Lett
; 12(11): 1678-1688, 2021 Nov 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34795856
20.
Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology.
ACS Med Chem Lett
; 12(9): 1380-1388, 2021 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34527178