Self-Trapping of Slow Electrons in the Energy Domain.

The interaction of light and swift electrons has enabled phase-coherent manipulation and acceleration of electron wave packets. Here, we investigate this interaction in a new regime where low-energy electrons (∼20-200 eV) interact with a phase-matched light field. Our analytical and one-dimensional numerical study shows that slow electrons are subject to strong confinement in the energy domain due to the nonvanishing curvature of the electron dispersion. The spectral trap is tunable and an appropriate choice of light field parameters can reduce the interaction dynamics to only two energy states. The capacity to trap electrons expands the scope of electron beam physics, free-electron quantum optics and quantum simulators.

CD177 on neutrophils engages stress-related behavioral changes in male mice.

Persistent psychological stress can affect immune homeostasis and is a key factor in the development of depression. Many efforts are focused on the identifcation of pathways that link the immune system and mood disorders. Here, we found that psychological stress caused an increase in the frequency of brain-associated neutrophils and the level of neutrophil-specific antigen CD177 on peripheral neutrophils in male mice. Upregulated levels of blood CD177 are associated with depression in humans. Neutrophil depletion or Cd177 deficiency protected mice from stress-induced behavioral deficits. Importantly, adoptive transfer of CD177+ neutrophils from stressed mice increased the frequency of brain-associated leukocytes, including neutrophils, and caused behavioral defects in naive mice. These effects may be related to the endothelial adhesion advantage of CD177+ neutrophils and the interference of serine protease on endothelial junction. Our findings suggest a critical link between circulating CD177+ neutrophils and psychological stress-driven behavioral disorder.

Inflammatory markers and physical frailty: towards clinical application.

Global population aging poses a tremendous burden on the health care system worldwide. Frailty is associated with decreased physical reserve and is considered an important indicator of adverse events in the older population. Therefore, there is growing interest in the early diagnosis and intervention of frailty, but the cellular mechanisms responsible for frailty are still not completely understood. Chronic inflammation is related to decreased physical function and increased disease risk. Additionally, multiple human and animal studies suggest that inflammation probably plays the largest role in contributing to frailty. Some inflammatory markers have been proposed to predict physical frailty. However, there are still large gaps in knowledge related to the clinical application of these markers in frail patients. Therefore, understanding the biological processes and identifying recognized and reliable markers are urgent and pivotal tasks for geriatricians. In the present review, we broadly summarize the inflammatory markers that may have potential diagnostic and therapeutic use, thereby translating them into health care for older people with frailty in the near future.

Dysregulation of acyl carnitines, pentose phosphate pathway and arginine and ornithine metabolism are associated with decline in intrinsic capacity in Chinese older adults.

BACKGROUND: Intrinsic capacity is the combination of individual physical and mental abilities, reflecting the aging degree of the older adults. However, the mechanisms and metabolic characteristics of the decline in intrinsic capacity are still unclear. AIMS: To identify metabolic signatures and associated pathways of decline in intrinsic capacity based on the metabolite features. METHODS: We recruited 70 participants aged 77.19 ± 8.31 years. The five domains of intrinsic capacity were assessed by Short Physical Performance Battery (for mobility), Montreal cognition assessment (for cognition), 30-Item Geriatric Depression Scale (for psychology), self-reported hearing/visual impairment (for sensory) and Nutritional risk screening (for vitality), respectively. The serum samples of participants were analyzed by liquid chromatography-mass spectrometry-based metabolomics, followed by metabolite set enrichment analysis and metabolic pathway analysis. RESULTS: There were 50 participants with a decline in intrinsic capacity in at least one of the domains. A total of 349 metabolites were identified from their serum samples. Overall, 24 differential metabolites, 5 metabolite sets and 13 pathways were associated with the decline in intrinsic capacity. DISCUSSION: Our results indicated that decline in intrinsic capacity had unique metabolomic profiles. CONCLUSION: The specific change of acyl carnitines was observed to be a feature of decline in intrinsic capacity. Dysregulation of the pentose phosphate pathway and of arginine and ornithine metabolism was strongly associated with the decline in intrinsic capacity.

Vibrational Dichroism of Chiral Valley Phonons.

Valley degrees of freedom in transition metal dichalcogenides thoroughly influence electron-phonon coupling and its nonequilibrium dynamics. We conducted a first-principles study of the quantum kinetics of chiral phonons following valley-selective carrier excitation with circularly polarized light. Our numerical investigations treat the ultrafast dynamics of electrons and phonons on equal footing within a parameter-free ab initio framework. We report the emergence of valley-polarized phonon populations in monolayer MoS2 that can be selectively excited at either the K or K' valleys depending on the light helicity. The resulting vibrational state is characterized by a distinctive chirality, which lifts time-reversal symmetry of the lattice on transient time scales. We show that chiral valley phonons can further lead to fingerprints of vibrational dichroism detectable by ultrafast diffuse scattering and persist beyond 10 ps. The valley polarization of nonequilibrium phonon populations could be exploited as an information carrier, thereby extending the paradigm of valleytronics to the domain of vibrational excitations.

A novel NET-related gene signature for predicting DLBCL prognosis.

BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) is an aggressive malignancy. Neutrophil extracellular traps (NETs) are pathogen-trapping structures in the tumor microenvironment that affect DLBCL progression. However, the predictive function of NET-related genes (NRGs) in DLBCL has received little attention. This study aimed to investigate the interaction between NRGs and the prognosis of DLBCL as well as their possible association with the immunological microenvironment. METHODS: The gene expression and clinical data of patients with DLBCL were downloaded from the Gene Expression Omnibus database. We identified 148 NRGs through the manual collection of literature. GSE10846 (n = 400, GPL570) was used as the training dataset and divided into training and testing sets in a 7:3 ratio. Univariate Cox regression analysis was used to identify overall survival (OS)-related NETs, and the least absolute shrinkage and selection operator was used to evaluate the predictive efficacy of the NRGs. Kaplan-Meier plots were used to visualize survival functions. Receiver operating characteristic (ROC) curves were used to assess the prognostic predictive ability of NRG-based features. A nomogram containing the clinical information and prognostic scores of the patients was constructed using multivariate logistic regression and Cox proportional risk regression models. RESULTS: We identified 36 NRGs that significantly affected patient overall survival (OS). Eight NRGs (PARVB, LYZ, PPARGC1A, HIF1A, SPP1, CDH1, S100A9, and CXCL2) were found to have excellent predictive potential for patient survival. For the 1-, 3-, and 5-year survival rates, the obtained areas under the receiver operating characteristic curve values were 0.8, 0.82, and 0.79, respectively. In the training set, patients in the high NRG risk group presented a poorer prognosis (p < 0.0001), which was validated using two external datasets (GSE11318 and GSE34171). The calibration curves of the nomogram showed that it had excellent predictive ability. Moreover, in vitro quantitative real-time PCR (qPCR) results showed that the mRNA expression levels of CXCL2, LYZ, and PARVB were significantly higher in the DLBCL group. CONCLUSIONS: We developed a genetic risk model based on NRGs to predict the prognosis of patients with DLBCL, which may assist in the selection of treatment drugs for these patients.

Floquet Gauge Anomaly Inflow and Arbitrary Fractional Charge in Periodically Driven Topological-Normal Insulator Heterostructures.

Usually, when coupling in a background gauge field, topological zero modes would yield an anomalous current at the interface, culminating in the zero-mode anomaly inflow, which is ultimately conserved by extra contributions from the topological bulk. However, the anomaly inflow mechanism for guiding Floquet steady states is rarely explored in periodically driven systems. Here we synthesize a driven topological-normal insulator heterostructure and propose a Floquet gauge anomaly inflow, associated with the occurrence of arbitrary fractional charge. Through our photonic modeling, we experimentally observed a Floquet gauge anomaly as the system was driven into anomalous topological phases. Prospectively, we believe our findings could pave a novel avenue on exploring Floquet gauge anomalies in driven systems of condensed matter, photonics, and ultracold atoms.

Superluminal k-Gap Solitons in Nonlinear Photonic Time Crystals.

We propose superluminal solitons residing in the momentum gap (k gap) of nonlinear photonic time crystals. These gap solitons are structured as plane waves in space while being periodically self-reconstructing wave packets in time. The solitons emerge from modes with infinite group velocity causing superluminal evolution, which is the opposite of the stationary nature of the analogous Bragg gap soliton residing at the edge of an energy gap (or a spatial gap) with zero group velocity. We explore the faster-than-light pulsed propagation of these k-gap solitons in view of Einstein's causality by introducing a truncated input seed as a precursor of a signal velocity forerunner, and find that the superluminal propagation of k-gap solitons does not break causality.

Reward motivation adaptation in people with negative schizotypal features: development of a novel behavioural paradigm and identifying its neural correlates using resting-state functional connectivity analysis.

Reward motivation in individuals with high levels of negative schizotypal traits (NS) has been found to be lower than that in their counterparts. But it is unclear that whether their reward motivation adaptively changes with external effort-reward ratio, and what resting-state functional connectivity (rsFC) is associated with this change. Thirty-five individuals with high levels of NS and 44 individuals with low levels of NS were recruited. A 3T resting-state functional brain scan and a novel reward motivation adaptation behavioural task were administrated in all participants. The behavioural task was manipulated with three conditions (effort > reward condition vs. effort < reward condition vs. effort = reward condition). Under each condition were rated 'wanting' and 'liking' for rewards. The seed-based voxel-wise rsFC analysis was conducted to explore the rsFCs associated with the 'wanting' and 'liking' ratings in individuals with high levels of NS. 'Wanting' and 'liking' ratings of individuals with high levels of NS significantly declined in the effort > reward condition but did not rebound as high as their counterparts in the effort < reward condition. The rsFCs in NS group associated with these ratings were altered. The altered rsFCs in NS group involved regions in the prefrontal lobe, dopaminergic brain regions (ventral tegmental area, substantia nigra), hippocampus, thalamus and cerebellum. Individuals with high levels of NS manifested their reward motivation adaptation impairment as a failure of adjustment adaptively during effort-reward imbalance condition and altered rsFCs in prefrontal, dopaminergic and other brain regions.

Mid-infrared Nb4N3-based superconducting nanowire single photon detectors for wavelengths up to 10 µm.

Mid-infrared (MIR) single-photon detection is emerging as an important technology for various applications. Superconducting nanowire single photon detectors (SNSPDs) fabricated with superconducting films with energy gaps of a few meV are natural broadband single-photon detectors. Recently, extending SNSPDs' operation wavelengths into the MIR region is highly attractive. γ-Nb4N3 has a reduced N content and lower energy gap than the commonly used δ-NbN, making SNSPDs based on γ-Nb4N3 film more sensitive to low energy photons. We report on a Nb4N3-SNSPD based on 62-nm wide nanowire, with an optical absorption enhancement design and an optimized device package for efficient ZBLAN fiber coupling and dark count filtering. The developed device has a unity intrinsic detection efficiency (IDE) in the 1.5-4 µm wavelength region, and the device detection efficiency at 2.95 µm was measured to be 32.5%, with an uncertainty of 12.7%. Furthermore, we reduced the device geometry, and measured 3-10 µm photon response of a device based on 5-nm film and 42-nm nanowire, with an IDE of 95%, 81%, 40%, and 6% for 4.8, 6, 8, and 10 µm, respectively.

Tri-n-butyl phosphate delays tissue repair by dysregulating neutrophil function in zebrafish.

Tri-n-butyl phosphate (TnBP) is a widely used organophosphate ester, but its effects on the regenerative process under damaging circumstances remain unknown. In the present study, zebrafish larvae were exposed to 0, 50, 100, 200 and 1000 µg/L TnBP, and the caudal fins were cut at 72 hours post fertilization (hpf). First, after exposure to TnBP, the number of total neutrophils decreased together with decreased neutrophils in the tail, and TnBP inhibited chemotaxis. Second, reactive oxygen species (ROS) levels in the zebrafish decreased greatly. Following exposure to TnBP, transcription levels of many genes regulating fin regeneration, such as fgf20a, fgfr1a, bmp2a and bmp4, were significantly downregulated, while inflammatory factors such as cxcl8a, cxcl18b, il-6, and tnfa were abnormally upregulated. In addition, TnBP inhibited the regenerative area after caudal fin amputation. The inflammatory state was adverse during the regenerative process. In summary, TnBP exposure is immunotoxic and decreases oxidative stress in injured zebrafish larvae.

Integrated transcriptome and metabolome analyses of biochar-induced pathways in response to Fusarium wilt infestation in pepper.

The present study used soils contaminated with Fusarium oxysporum f. sp. capsici (CCS) and CCS amended with bamboo biochar (CCS + BC) to grow the pepper variety Qujiao No.1. The physiological performance, and transcriptome and metabolome profiling in leaf (L) and fruit (F) of Qujiao No.1 were conducted. Application of biochar improved soil properties, pepper plant nutrition and increased activities of enzymes related to pest/disease resistance, leading to superior physiological performance and lesser F. wilt disease incidence than plants from CCS. Most of the differentially expressed genes (DEGs) and differentially accumulated metabolites (DAMs) were involved in protein processing in endoplasmic reticulum (fruit), plant pathogen interaction (fruit), photosynthesis (leaf), phenylpropanoid biosynthesis (both tissues) and metabolic pathways (both tissues). Biochar improved plant photosynthesis, enhanced the immune system, energy production and increased stress signaling pathways. Overall, our results provide evidence of a number of pathways induced by biochar in pepper regulating its response to F. wilt disease.

Large-area TaN superconducting microwire single photon detectors for X-ray detection.

With the development of superconducting nanowire single photon detectors, increasing numbers of important applications are being explored, covering not only low-energy optical photon detection but also high-energy photon and particle detection. In this work, 100-nm-thick TaN superconducting microwire single photon detectors (SMSPDs) with large active areas were prepared for X-ray detection, and their response characteristics to X-rays were studied. The results showed that our TaN SMSPDs were able to detect X-rays at a wide range of bias currents and working temperatures. The detectors could distinguish different energy X-rays under suitable working conditions, and the energy resolving power was strongly related to the bias current.

Quantum Interference Visibility Spectroscopy in Two-Color Photoemission from Tungsten Needle Tips.

When two-color femtosecond laser pulses interact with matter, electrons can be emitted through various multiphoton excitation pathways. Quantum interference between these pathways gives rise to a strong oscillation of the photoemitted electron current, experimentally characterized by its visibility. In this Letter, we demonstrate the two-color visibility spectroscopy of multiphoton photoemissions from a solid-state nanoemitter. We investigate the quantum pathway interference visibility over an almost octave-spanning wavelength range of the fundamental (ω) femtosecond laser pulses and their second harmonic (2ω). The photoemissions show a high visibility of 90% ± 5%, with a remarkably constant distribution. Furthermore, by varying the relative intensity ratio of the two colors, we find that we can vary the visibility between 0% and close to 100%. A simple but highly insightful theoretical model allows us to explain all observations, with excellent quantitative agreements. We expect this work to be universal to all kinds of photo-driven quantum interference, including quantum control in physics, chemistry, and quantum engineering.

Association of frailty with quality of life in older hypertensive adults: a cross-sectional study.

BACKGROUND: Hypertension is one of the most common chronic cardiovascular diseases in older adults. Frailty and hypertension often coexist in older people, but few studies have explored frailty in older hypertensive adults. We aimed to explore the association of frailty with quality of life in older hypertensive adults. METHOD: We collected the data of 291 patients with hypertension aged ≥ 60 years. Blood pressure was measured with a standard aneroid sphygmomanometer and an ambulatory blood pressure monitor. The characteristics of the Fried phenotype were used to assess physical frailty. The Medical Outcomes Study's 36-Item Short Form Health Survey (SF-36) was used to assess the quality of life. RESULTS: Forty-eight (16.5%) patients were frail. Compared with pre-frail or robust older hypertensive patients, those who were frail were older, had higher incidences of living alone, a longer duration of hypertension, lower grip strength, and slower walking speed. Moreover, frail patients had a lower diastolic blood pressure (DBP) and mean arterial pressure (MAP), more chronic diseases, a lower proportion of beta-blocker usage, and worse quality of life. Frailty was positively correlated with pulse pressure and negatively correlated with DBP and MAP, but these associations disappeared after adjustment by age. The SF-36 score was negatively correlated with frailty and positively correlated with grip strength and walking speed. After adjusting for age, the SF-36 total score remained negatively correlated with frailty and positively correlated with walking speed. Frailty states remained significantly associated with the SF-36 score. CONCLUSION: Frailty was associated with a worse quality of life in older adults with hypertension. Frailty prevention and intervention may help improve the quality of life of older adults with hypertension.

Engineering zero modes, Fano resonance, and Tamm surface states in the waveguide-array realization of the modified Su-Schrieffer-Heeger model.

In this article, we developed a generalized coupled-mode theory for mixing an isolated state with a continuum having an intrinsic energy gap, which dubbed as "the bound states in the gapped continuum" (BIGC). We investigated the mixture interaction by mimicking the Su-Schrieffer-Heeger model in an optical coupled waveguide array (WA), and presented a unified engineering mechanism for topologically-protected zero modes, Fano resonance, and Tamm surface states, even though those phenomena are diverse in topological insulators, atomic physics and semiconductors, respectively. By tuning the on-site potential and coupling strength of the isolated state, we found the unified operating characteristics for zero modes, Fano resonance, and Tamm states, with demonstrating their localization, transmission spectra, and distinct evolution dynamics explicitly. As an extension for triple-modes coupling, two special sandwich-like configurations are studied: the isolated-continuous-isolated and continuous-isolated-continuous configurations lead to adiabatic eliminations and domain walls, respectively, revealing possible applications and wide connections in many fields of physics and optics.

Anomalous Photon-Induced Near-Field Electron Microscopy.

We reveal the classical and quantum regimes of free electron interaction with radiation, common to the general variety of radiation sources (e.g., a Smith-Purcell radiation), the dielectric laser accelerator, and photo-induced near-field electron microscopy (PINEM). Modeling the electron with initial conditions of a coherent quantum electron wave packet, its topology in phase space uniquely defines a universal distinction of three interaction regimes: point-particle-like acceleration, a quantum wave function (PINEM), and a newly reported regime of anomalous PINEM (APINEM). The quantum interference beat of APINEM is capable of improving the spectral resolution of postselective electron microscopy. The particle-wave duality transition between regimes reveals the history-dependent nature of quantum electron interaction with light.

Observation of Anomalous π Modes in Photonic Floquet Engineering.

Recent progress on Floquet topological phases has shed new light on time-dependant quantum systems, among which one-dimensional (1D) Floquet systems have been under extensive theoretical research. However, an unambiguous experimental observation of these 1D Floquet topological phases is still lacking. Here, by periodically bending an ultrathin metallic array of coupled corrugated waveguides, a photonic Floquet simulator was well designed and successfully fabricated to mimic the periodically driven Su-Schrieffer-Heeger model. Intriguingly, under moderate driven frequencies, we report the first observation of the anomalous Floquet topological π mode, propagating along the array's boundary. The different evolutionary behaviors between static and nonstatic topological end modes have been clearly demonstrated by the microwave near-field experiment. Furthermore, the experiment in the fast-driving regime also reveals the universal high-frequency behavior in driven systems. Our photonic simulator can serve as a versatile testing ground for various phenomena related to time-dependant 1D quantum phases, such as Thouless pumping and dynamical localization.

Flexibly designed spoof surface plasmon waveguide array for topological zero-mode realization.

We propose a flexibly designed photonic system based on ultrathin corrugated metallic "H-bar" waveguide that supports spoof surface plasmon polariton (SPP) at microwave frequencies. Five designs were presented, in order to demonstrate flexibility according to varying height, period, core width, rotation, and shifting on the "H-bar" unit of the waveguide. The propagation constant between two hybrid designs of period and height structure was then shown in order to study the coupling effect. Next, we constructed a coupled waveguide array that followed the Su-Schrieffer-Heeger (SSH) model. This model was constructed by a hybrid design with the identical propagation constant of each waveguide, except it had dimerized spacing. The propagation feature of topological zero mode was then observed as theoretically expected in the dimerized array. Our proposed spoof SPP waveguide array has great flexibility to be used as a powerful experiment platform, particularly in photonic simulation of the quantum or topological phenomena described by Schrödinger equation in condensed matters.