Arbekacin - A Novel Antibiotic for Critical Infections.

Antibiotic resistance is one of the biggest menace to global health. Deaths from Drug-resistant infections is set to escalate exponentially. Pipeline for new antibacterials is almost empty. The World Health Organization has reinforced its warning that to tackle growing threat of antimicrobial resistance, development of a new antibiotics is seriously lacking. Arbekacin is a novel aminoglycoside primarily used in the treatment of infections caused by resistant Staphylococcus Aureus i.e. Methicillin Resistant Staphylococcus Aureus (MRSA). Besides MRSA it also demonstrates activity against Enterococci and several Gram negative pathogens such as Klebsiella pneumonia, Pseudomonas aeruginosa, Acinetobacter baumannii including resistant strain. Arbekacin which has been used in Japan and Korea since more than two and half decades has been recently approved in India. This review will examine how Arbekacin evades the common mechanisms of antibiotic resistance, the pharmacokinetics of Arbekacin, and the various pharmacological properties and its spectrum of in vitro activity. The results of clinical trials on Arbekacin are also described, as is the patient safety and tolerability observed during these studies.

Antecedents for blockchain technology-enabled sustainable agriculture supply chain.

Blockchain can solve the problems that the agriculture supply chain (ASC) is facing to achieve sustainable growth. In a nation like India, blockchain application in the supply chain is still new; therefore, supply chain players need a better understanding and awareness of blockchain through valuable insights. This article aims to study the mediating role of blockchain technology adoption (BLCT) for sustainable supply chain performance (SSCP). This study investigates the influence of numerous factors such as green and lean practices, supply chain integration, supply chain risk, performance expectancy, top management support, cost, internal and external environmental conditions, regulatory support, and innovation capability on BLCT adoption. A sample of 316 respondents from Indian ASC industries was collected, and structural equation modeling (SEM) was used. This study's outcomes show that green and lean practices, supply chain integration, supply chain risks, internal and external conditions, regulatory support, innovation capability, and cost positively influence BLCT adoption. Moreover, BLCT positively influences sustainable agriculture supply chain performance. This article is valuable for policymakers, managers, service providers, researchers, and academicians to understand the role of factors in influencing BLCT and BLCT's role in improving sustainable supply chain performance (SSCP).