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1.
Opt Express ; 30(7): 11959-11972, 2022 Mar 28.
Artigo em Inglês | MEDLINE | ID: mdl-35473127

RESUMO

Even though it is in high demand to introduce a nano-structure (NS) light extraction technology on a silicon nitride to be used as a thin film encapsulation material for an organic light-emitting diode (OLED), only an industry-incompatible wet method has been reported. This work demonstrates a double-layer NS fabrication on the silicon nitride using a two-step organic vapor phase deposition (OVPD) of an industry-compatible dry process. The NS showed a wrinkle-like shape caused by coalescence of the nano-lenses. The NS integrated top-emitting OLED revealed 40 percent enhancement of current efficiency and improvement of the luminance distribution and color change according to viewing angle.

2.
J Biol Chem ; 287(7): 4808-17, 2012 Feb 10.
Artigo em Inglês | MEDLINE | ID: mdl-22117066

RESUMO

Our objective was to determine whether lipocalin-2 (Lcn2) regulates cardiomyocyte apoptosis, the mechanisms involved, and the functional significance. Emerging evidence suggests that Lcn2 is a proinflammatory adipokine associated with insulin resistance and obesity-related complications, such as heart failure. Here, we used both primary neonatal rat cardiomyocytes and H9c2 cells and demonstrated for the first time that Lcn2 directly induced cardiomyocyte apoptosis, an important component of cardiac remodeling leading to heart failure. This was shown by detection of DNA fragmentation using TUNEL assay, phosphatidylserine exposure using flow cytometry to detect annexin V-positive cells, caspase-3 activity using enzymatic assay and immunofluorescence, and Western blotting for the detection of cleaved caspase-3. We also observed that Lcn2 caused translocation of the proapoptotic protein Bax to mitochondria and disruption of mitochondrial membrane potential. Using transient transfection of GFP-Bax, we confirmed that Lcn2 induced co-localization of Bax with MitoTracker® dye. Importantly, we used the fluorescent probe Phen Green SK to demonstrate an increase in intracellular iron in response to Lcn2, and depleting intracellular iron using an iron chelator prevented Lcn2-induced cardiomyocyte apoptosis. Administration of recombinant Lcn2 to mice for 14 days increased cardiomyocyte apoptosis as well as an acute inflammatory response with compensatory changes in cardiac functional parameters. In conclusion, Lcn2-induced cardiomyocyte apoptosis is of physiological significance and occurs via a mechanism involving elevated intracellular iron levels and Bax translocation.


Assuntos
Proteínas de Fase Aguda/metabolismo , Apoptose/fisiologia , Ferro/metabolismo , Lipocalinas/metabolismo , Miócitos Cardíacos/metabolismo , Proteínas Oncogênicas/metabolismo , Proteínas de Fase Aguda/farmacologia , Animais , Anexina A5/metabolismo , Apoptose/efeitos dos fármacos , Western Blotting , Caspase 3/metabolismo , Linhagem Celular , Fragmentação do DNA/efeitos dos fármacos , Marcação In Situ das Extremidades Cortadas , Lipocalina-2 , Lipocalinas/farmacologia , Camundongos , Miócitos Cardíacos/citologia , Proteínas Oncogênicas/farmacologia , Fosfatidilserinas/farmacologia , Transporte Proteico/efeitos dos fármacos , Transporte Proteico/fisiologia , Ratos , Proteína X Associada a bcl-2/metabolismo
3.
J Nanosci Nanotechnol ; 13(9): 6416-9, 2013 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-24205673

RESUMO

A silicon nanowire one-dimensional thermoelectric device is presented as a solution to enhance thermoelectric performance. A top-down process is adopted for the definition of 50 nm silicon nanowires (SiNWs) and the fabrication of the nano-structured thermoelectric devices on silicon on insulator (SOl) wafer. To measure the Seebeck coefficients of 50 nm width n- and p-type SiNWs, a thermoelectric test structure, containing SiNWs, micro-heaters and temperature sensors is fabricated. Doping concentration is 1.0 x 10(20) cm(-3) for both for n- and p-type SiNWs. To determine the temperature gradient, a temperature coefficient of resistance (TCR) analysis is done and the extracted TCR value is 1750-1800 PPM x K(-1). The measured Seebeck coefficients are -127.583 microV x K(-1) and 141.758 microV x K(-1) for n- and p-type SiNWs, respectively, at room temperature. Consequently, power factor values are 1.46 mW x m(-1) x K(-2) and 1.66 mW x m(-1) x K(-2) for n- and p-type SiNWs, respectively. Our results indicate that SiNWs based thermoelectric devices have a great potential for applications in future energy conversion systems.

4.
J Nanosci Nanotechnol ; 13(12): 7801-5, 2013 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-24266143

RESUMO

We fabricated a thermoelectric device with a silicide/silicon laminated hetero-structure by using RF sputtering and rapid thermal annealing. The device was observed to have Ohmic characteristics by I-V measurement. The temperature differences and Seebeck coefficients of the proposed silicide/silicon laminated and bulk structure were measured. The laminated thermoelectric device shows suppression of heat flow from the hot to cold side. This is supported by the theory that the atomic mass difference between silicide and silicon creates a scattering center for phonons. The major impact of our work is that phonon transmission is suppressed at the interface between silicide and silicon without degrading electrical conductivity. The estimated thermal conductivity of the 3-layer laminated device is 126.2 +/- 3.7 W/m. K. Thus, by using the 3-layer laminated structure, thermal conductivity is reduced by around 16% compared to bulk silicon. However, the Seebeck coefficient of the thermoelectric device is degraded compared to that of bulk silicon. It is understood that electrical conductivity is improved by using silicide as a scattering center.

5.
ACS Appl Mater Interfaces ; 15(10): 13131-13143, 2023 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-36791219

RESUMO

Problematic issues with electrically inert binders have been less serious in the conventional lithium-ion batteries by virtue of permeable liquid electrolytes (LEs) for ionic connection and/or carbonaceous additives for electronic connection in the electrodes. Contrary to electron-conductive binders used to maximize an active loading level, the development of ion-conductive binders has been lacking owing to the LE-filled electrode configuration. Herein, we represent a tactical strategy for improving the interfacial Li+ conduction in all-solid-state electrolyte-free graphite (EFG) electrodes where the solid electrolytes are entirely excluded, using lithium-substitution-modulated (LSM) binders. Finely tuning a lithium substitution ratio, a conductive LSM-carboxymethyl cellulose (CMC) binder is prepared from a controlled direct Na+/Li+ exchange reaction without a hazardous acid involvement. The EFG electrode employing LSM with a maximum degree of substitution of lithium (DSLi) of ∼68% in our study shows a considerably higher rate capability of 1.05 mA h cm-2 at 1 C and a capacity retention of ∼61.9% after 200 cycles at 0.5 C than those using sodium-CMC (Na-CMC) (0.78 mA h cm-2, ∼49.5%) and LSM with ∼35% lithium substitution (0.93 mA h cm-2, ∼55.4%). More importantly, the correlation between the phase transition near the bottom region of the EFG electrode and the state of charge (SOC) is systematically investigated, clarifying that the improvement of the interfacial conduction is proportional to the DSLi of the CMC binders. Theoretical calculations combined with experimental results further verify that creating the continuous interface through abundant pathways for mobile ions using the Li+-conductive binder is the enhancement mechanism of the interfacial conduction in the EFG electrode, mitigating serious charge transfer resistance.

6.
Bioorg Med Chem Lett ; 22(5): 2119-24, 2012 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-22305583

RESUMO

3,4-Dihydropyrimidin-2(1H)-ones (DHPMs) were selected and derivatized through a HIV-1 replication assay based on GFP reporter cells. Compounds 14, 25, 31, and 36 exhibited significant inhibition of HIV-1 replication with a good safety profile. Chiral separation of each enantiomer by fractional crystallization showed that only the S enantiomer retained anti-HIV activity. Compound (S)-40, a novel and potent DHPM analog, could serve as an advanced lead for further development and the determination of the mechanism of action.


Assuntos
Fármacos Anti-HIV/química , Fármacos Anti-HIV/farmacologia , HIV-1/efeitos dos fármacos , Pirimidinonas/química , Pirimidinonas/farmacologia , Replicação Viral/efeitos dos fármacos , Desenho de Fármacos , Infecções por HIV/tratamento farmacológico , Humanos , Estereoisomerismo , Relação Estrutura-Atividade
7.
Bioorg Med Chem Lett ; 22(7): 2522-6, 2012 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-22374216

RESUMO

Following the previous SAR of a novel dihydropyrimidinone scaffold as HIV-1 replication inhibitors a detailed study directed towards optimizing the metabolic stability of the ester functional group in the dihydropyrimidinone (DHPM) scaffold is described. Replacement of the ester moiety by thiazole ring significantly improved the metabolic stability while retaining antiviral activity against HIV-1 replication. These novel and potent DHPMs with bioisosteres could serve as advanced leads for further optimization.


Assuntos
Transcriptase Reversa do HIV/antagonistas & inibidores , HIV-1/efeitos dos fármacos , Pirimidinonas/síntese química , Inibidores da Transcriptase Reversa/síntese química , Replicação Viral/efeitos dos fármacos , Animais , Linhagem Celular Tumoral , Estabilidade de Medicamentos , HIV-1/fisiologia , Humanos , Microssomos Hepáticos/metabolismo , Modelos Moleculares , Nevirapina/farmacologia , Pirimidinonas/farmacologia , Ratos , Inibidores da Transcriptase Reversa/farmacologia , Relação Estrutura-Atividade , Tiazóis/química
8.
J Nanosci Nanotechnol ; 12(4): 3552-4, 2012 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-22849166

RESUMO

50 nm wide n-type silicon nanowires have been manufactured by using a top-down process in order to investigate the thermoelectric properties of silicon nanowire. Nanowire test structures with platinum heaters and temperature sensors were fabricated. The extracted temperature coefficient of resistance (TCR) of the temperature sensors was 786.6 PPM/K. Also, the extracted Seebeck coefficient and power factor of the 50 nm wide phosphorus doped n-type silicon nanowires were -118 miroV/K and 2.16 mW x K(-2) x m(-1).

9.
J Nanosci Nanotechnol ; 11(8): 7339-42, 2011 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-22103191

RESUMO

In this paper, n/p-type nickel-silicided Schottky diodes were fabricated by incorporating antimony atoms near the nickel silicide/Si junction interface and the electrical characteristics were studied through measurements and simulations. The effective Schottky barrier height (SBH) for electron, extracted from the thermionic emission model, drastically decreased from 0.68 to less than 0.1 eV while that for hole slightly increased from 0.43 to 0.53 eV. In order to identify the current conduction mechanisms, the experimental current-temperature-voltage characteristics for the n-type diode were fitted based on various models for transport of charge carrier in Schottky diodes. As the result, the large change in effective SBH for electron is ascribed to trap-assisted tunneling rather than barrier height inhomogeneity.

10.
Korean J Women Health Nurs ; 27(3): 243-255, 2021 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-36311982

RESUMO

Purpose: This study aimed to develop a lifestyle modification (LSM) mobile application based on the Android operating system for overweight and obese breast cancer survivors (BCS) in Korea and evaluate its usability. Methods: The content analysis, design, development, implementation, and evaluation of the LSM intervention mobile application for overweight and obese BCS was conducted by identifying survivors' needs, searching the literature, and reviewing existing mobile applications. The survey was conducted from June 1 to December 28, 2020 at Jeonju city, Korea. Results: The mobile application for BCS included dietary and exercise information, weight logs, as well as distress and daily achievement check. It also included information and videos on the prevention of breast cancer recurrence and used a communication bulletin board. Expert and user usability evaluation of its content and functions confirmed that it was appropriate and satisfactory for overweight and obese BCS. Conclusion: This LSM mobile application developed for overweight and obese BCS was found to be appropriate for use. It can be applied for further study of effectiveness on improving their health and maintaining a healthy lifestyle, to ultimately improve quality of life.

11.
Mater Horiz ; 8(11): 3141-3148, 2021 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-34570854

RESUMO

In this study, it is shown that fluorinated azide, employed as a functional additive to photomultiplication-type organic photodiodes (PM-OPDs), can not only enhance the operational stability by freezing the morphology consisting of matrix polymer/localized acceptor but also stabilize the trapped electron states such that the photomultiplication mechanism can be accelerated further, leading to exceptionally high external quantum efficiency (EQE). The consequent semitransparent OPD consisting of molybdenum oxide (MoO3)/Au/MoO3/photoactive layer/polyethyleneimine ethoxylated/indium tin oxide (ITO) rendered a maximum EQE of over 500 000% and 370 000% under bottom and top illumination, respectively. Owing to the remarkably high EQE, high specific detectivity of 5.6 × 1013 Jones and low noise-equivalent power of 5.35 × 10-15 W Hz-0.5 were also demonstrated. Furthermore, the OPD demonstrated stable performance during 20 h of continuous operation and minimal performance degradation even after the damp heat test. To fully visualize the advantages of the proposed high-EQE, top-illuminated, semitransparent OPD with spectral asymmetry between absorption and detection, a reflection-type fingerprint platform consisting of 1 OPD-1 oxide field-effect transistor complementary metal-oxide-semiconductor backplane (300 ppi) is designed and fabricated. The successful recognition of the fingerprint of one of the authors is demonstrated, which indicates the feasibility of the proposed PM-OPD for sensing weak light intensity.

12.
Korean J Women Health Nurs ; 26(1): 28-36, 2020 Mar 31.
Artigo em Coreano | MEDLINE | ID: mdl-36311846

RESUMO

Purpose: This study investigated lifestyle, depression, marital intimacy, and quality of life (QoL) in breast cancer survivors, with the goal of identifying the impacts of these factors on QoL. Methods: A sample of 146 breast cancer survivors was surveyed in this cross-sectional study. Data were collected from March 20 to May 30, 2019, using self-report structured questionnaires at a hospital located in Jeonju, Korea. Data were analyzed using the independent t-test, analysis of variance, Pearson correlation coefficients, and hierarchical regression analysis. Participants agreed to complete a face-to-face interview, including administration of the Health Promoting Lifestyle Profile II, Depression Anxiety Stress Scale 21-Depression Scale, Marital Intimacy Scale, and Functional Assessment Cancer Therapy-Breast Cancer tool. Results: QoL was positively correlated with lifestyle (r=.49, p<.001) and marital intimacy (r=.45, p<.001) and negatively correlated with depression (r=-.72, p<.001). Hierarchical multiple regression analysis showed that depression (ß=-0.63, p<.001), marital intimacy (ß=0.19, p=.001), and lifestyle (ß=0.13, p=.031) had significant effects on the QoL of breast cancer survivors, accounting for 63.3% of variance in related QoL. Conclusion: This study provides insights into how breast cancer survivors' QoL was influenced by depression, marital intimacy, and lifestyle. To improve the QoL of breast cancer survivors, healthcare providers should consider developing strategies to decrease depression, to increase marital intimacy, and to improve lifestyle.

13.
Int J Surg Case Rep ; 60: 186-190, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31229774

RESUMO

INTRODUCTION: Tamoxifen is often used as antihormonal therapy in patients with breast cancer. However, it has various side effects, of which pneumonia is a rare occurrence. PRESENTATION OF CASE: A 46-year-old female patient with breast cancer underwent surgical treatment. Tamoxifen was administered as adjuvant therapy on post-operative day 14; 2 days after administration of tamoxifen, the patient developed high fever of more than 39 °C and cough with dyspnea. Based on chest computed tomography findings of ground glass opacity, interlobular septal thickening, and mild pleural effusion in both lungs, eosinophilic pneumonia was suspected. Tamoxifen was discontinued and methylprednisolone injection was administered; the patient showed improvement of symptoms and radiographic findings. DISCUSSION: Tamoxifen was suspected as the cause of eosinophilic pneumonia since the patient developed high-grade fever at the time of tamoxifen administration, which subsided after discontinuation of the treatment. Other factors considered as the cause of pneumonia were examined, but all showed negative results. In order to confirm tamoxifen as the cause of pneumonia, tamoxifen treatment was restarted at follow-up (post-operative day 47); however, after 1 month, regular administration was not possible due to the development of itching symptom and difficulty in obtaining the patient's cooperation. CONCLUSION: The study highlights that if the patient on tamoxifen develops high fever and cough with dyspnea at 2-3days after the first administration, tamoxifen-induced pneumonia should be suspected.

14.
J Microbiol Biotechnol ; 18(12): 1990-6, 2008 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19131704

RESUMO

Astaxanthin has shown antioxidant, antitumor, and antiinflammatory activities; however, its molecular action and mechanism in the nervous system have yet to be elucidated. We examined the in vitro effects of astaxanthin on the production of nitric oxide (NO), as well as the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-stimulated BV2 microglial cells. Astaxanthin inhibited the expression or formation of nitric oxide (NO), iNOS and COX-2 in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells. Astaxanthin also suppressed the protein levels of iNOS and COX-2 in LPS-stimulated BV2 microglial cells. These results suggest that astaxanthin, probably due to its antioxidant activity, inhibits the production of inflammatory mediators by blocking iNOS and COX-2 activation or by the suppression of iNOS and COX-2 degradation.


Assuntos
Ciclo-Oxigenase 2/metabolismo , Lipopolissacarídeos/imunologia , Microglia/metabolismo , Óxido Nítrico Sintase Tipo II/metabolismo , Óxido Nítrico/metabolismo , Animais , Linhagem Celular , Sobrevivência Celular , Ciclo-Oxigenase 2/genética , Interpretação Estatística de Dados , Expressão Gênica/efeitos dos fármacos , Camundongos , Microglia/efeitos dos fármacos , Óxido Nítrico Sintase Tipo II/genética , Xantofilas/farmacologia
15.
ACS Appl Mater Interfaces ; 10(22): 18942-18947, 2018 Jun 06.
Artigo em Inglês | MEDLINE | ID: mdl-29749737

RESUMO

Recently, we have addressed that a formation mechanism of a nanolens array (NLA) fabricated by using a maskless vacuum deposition is explained as the increase in surface tension of organic molecules induced by their crystallization. Here, as another research using finite difference time domain simulations, not electric field intensities but transmitted energies of electromagnetic waves inside and outside top-emitting blue organic light-emitting diodes (TOLEDs), without and with NLAs, are obtained, to easily grasp the effect of NLA formation on the light extraction of TOLEDs. Interestingly, the calculations show that NLA acts as an efficient light extraction structure. With NLA, larger transmitted energies in the direction from emitting layer to air are observed, indicating that NLAs send more light to air otherwise trapped in the devices by reducing the losses by waveguide and absorption. This is more significant for higher refractive index of NLA. Simulation and measurement results are consistent. A successful increase in both light extraction efficiency and color stability of blue TOLEDs, rarely reported before, is accomplished by introducing the highly process-compatible NLA technology using the one-step dry process. Blue TOLEDs integrated with a N, N'-di(1-naphthyl)- N, N'-diphenyl-(1,1'-biphenyl)-4,4'-diamine NLA with a refractive index of 1.8 show a 1.55-times-higher light extraction efficiency, compared to those without it. In addition, viewing angle characteristics are enhanced and image blurring is reduced, indicating that the manufacturer-adaptable technology satisfies the requirements of highly efficient and color-stable top-emission displays.

16.
J Microbiol Biotechnol ; 17(5): 847-52, 2007 May.
Artigo em Inglês | MEDLINE | ID: mdl-18051308

RESUMO

This study investigated an efficient method for the extraction of astaxanthin from the red yeast Xanthophyllomyces dendrorhous. The extraction process comprised three steps: (1) cultivating the yeast; (2) treating the yeast culture suspension with microwaves to destroy the cell walls and microbodies; and (3) drying the yeast and extracting the astaxanthin pigment using ethanol, methanol, acetone, or a mixture of the three as the extraction solvent. Ultimately, various treatment tests were performed to determine the conditions for optimal pigment extraction, and the total carotenoid and astaxanthin contents were quantified. A frequency of 2,450 MHz, an output of 500 watts, and irradiation time of 60 s were the most optimum conditions for yeast cell wall destruction. Furthermore, optimal pigment extraction occurred when using a cell density of 10 g/l at 30 C over 24 h, with a 10% volume of ethanol.


Assuntos
Basidiomycota/química , Basidiomycota/crescimento & desenvolvimento , Basidiomycota/metabolismo , Basidiomycota/efeitos da radiação , Fermentação , Microbiologia Industrial , Micro-Ondas , Solventes , Xantofilas/análise , Xantofilas/isolamento & purificação
17.
Nanoscale ; 9(1): 230-236, 2017 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-27906406

RESUMO

To date, all deposition equipment has been developed to produce planar films. Thus lens arrays with a lens diameter of <1 mm have been manufactured by combining deposition with other technologies, such as masks, surface treatment, molding etc. Furthermore, a nano-lens array (NLA) with a sufficiently small lens diameter (<1 µm) is necessary to avoid image quality degradation in high resolution displays. In this study, an organic NLA made using a conventional deposition technique - without combining with other techniques - is reported. Very interestingly, grazing-incidence small-angle X-ray scattering (GI-SAXS) experiments indicate that the NLA is formed by the crystallization of organic molecules and the resulting increase in surface tension. The lens diameter can be tuned for use with any kind of light by controlling the process parameters. As an example of their potential applications, we use NLAs as a light extraction film for organic light emitting diodes (OLEDs). The NLA is integrated by directly depositing it on the top electrode of a collection of OLEDs. This is a dry process, meaning that it is fully compatible with the current OLED production process. Devices with NLAs exhibited a light extraction efficiency 1.5 times higher than devices without, which corresponds well with simulation results. The simulations show that this high efficiency is due to the reduction of the guided modes by scattering at the NLA. The NLAs also reduce image blurring, indicating that they increase color stability.

18.
PLoS One ; 9(2): e87708, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24498359

RESUMO

The activities and side effects of 5-lipoxygenase (5-LO) inhibitors can be predicted by identifying their redox mechanisms. In this study, we developed a fluorescence-based method to measure the redox potential of 5-LO inhibitors and compared it to the conventional, absorbance-based method. After the pseudo-peroxidase reaction, the amount of remaining lipid peroxide was quantified using the H2DCFDA (2',7'-dichlorodihydrofluorescein diacetate) fluorescence dye. Our method showed large signal windows and provided comparable redox potential values. Importantly, the redox mechanisms of known inhibitors were accurately measured with the fluorescence assay, whereas the conventional, absorbance-based method showed contradictory results. Our findings suggest that our developed method is a better alternative for classifying the redox potential of 5-LO inhibitors, and the fluorescence assay can be effectively used to study the mechanisms of action that are related to redox cycling.


Assuntos
Araquidonato 5-Lipoxigenase/química , Bioensaio/métodos , Corantes Fluorescentes/análise , Inibidores de Lipoxigenase/análise , Inibidores de Lipoxigenase/química , Relação Dose-Resposta a Droga , Fluoresceínas/análise , Fluorescência , Humanos , Peróxidos Lipídicos/análise , Oxirredução
19.
Nanotechnology ; 23(40): 405707, 2012 Oct 12.
Artigo em Inglês | MEDLINE | ID: mdl-22995969

RESUMO

Silicon-based thermoelectric nanowires were fabricated by using complementary metal-oxide-semiconductor (CMOS) technology. 50 nm width n- and p-type silicon nanowires (SiNWs) were manufactured using a conventional photolithography method on 8 inch silicon wafer. For the evaluation of the Seebeck coefficients of the silicon nanowires, heater and temperature sensor embedded test patterns were fabricated. Moreover, for the elimination of electrical and thermal contact resistance issues, the SiNWs, heater and temperature sensors were fabricated monolithically using a CMOS process. For validation of the temperature measurement by an electrical method, scanning thermal microscopy analysis was carried out. The highest Seebeck coefficients were - 169.97 µV K(-1) and 152.82 µV K(-1) and the highest power factors were 2.77 mW m(-1) K(-2) and 0.65 mW m(-1) K(-2) for n- and p-type SiNWs, respectively, in the temperature range from 200 to 300 K. The larger power factor value for n-type SiNW was due to the higher electrical conductivity. The total Seebeck coefficient and total power factor for the n- and p-leg unit device were 157.66 µV K(-1) and 9.30 mW m(-1) K(-2) at 300 K, respectively.

20.
ACS Med Chem Lett ; 3(8): 678-82, 2012 Aug 09.
Artigo em Inglês | MEDLINE | ID: mdl-24900529

RESUMO

We identified a novel class of aryl-substituted triazine compounds as potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) during a high-throughput screening campaign that evaluated more than 200000 compounds for antihuman immunodeficiency virus (HIV) activity using a cell-based full replication assay. Herein, we disclose the optimization of the antiviral activity in a cell-based assay system leading to the discovery of compound 27, which possessed excellent potency against wild-type HIV-1 (EC50 = 0.2 nM) as well as viruses bearing Y181C and K103N resistance mutations in the reverse transcriptase gene. The X-ray crystal structure of compound 27 complexed with wild-type reverse transcriptase confirmed the mode of action of this novel class of NNRTIs. Introduction of a chloro functional group in the pyrazole moiety dramatically improved hERG and CYP inhibition profiles, yielding highly promising leads for further development.

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