Detalhe da pesquisa
1.
Design and discovery of C2-fluoroalkyl iminothiazine dioxides as BACE inhibitors.
Bioorg Med Chem Lett
; 56: 128463, 2022 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34838652
2.
Analysis of amino acids, hydroxy acids, and amines in CR chondrites.
Meteorit Planet Sci
; 55(11): 2422-2439, 2020 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-33536738
3.
Quantitation of α-hydroxy acids in complex prebiotic mixtures via liquid chromatography/tandem mass spectrometry.
Rapid Commun Mass Spectrom
; 30(18): 2043-51, 2016 09 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-27467333
4.
Design and synthesis of water soluble ß-aminosulfone analogues of SCH 900229 as γ-secretase inhibitors.
Bioorg Med Chem Lett
; 26(23): 5836-5841, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27836402
5.
MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition.
J Pharmacol Exp Ther
; 355(3): 397-409, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26407721
6.
Use of molecular modeling aided design to dial out hERG liability in adenosine A(2A) receptor antagonists.
Bioorg Med Chem Lett
; 25(15): 2958-62, 2015 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26048804
7.
Primordial synthesis of amines and amino acids in a 1958 Miller H2S-rich spark discharge experiment.
Proc Natl Acad Sci U S A
; 108(14): 5526-31, 2011 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-21422282
8.
A plausible simultaneous synthesis of amino acids and simple peptides on the primordial Earth.
Angew Chem Int Ed Engl
; 53(31): 8132-6, 2014 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-24966137
9.
Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors.
Bioorg Med Chem Lett
; 23(3): 844-9, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23265892
10.
Chemical evolution of primordial salts and organic sulfur molecules in the asteroid 162173 Ryugu.
Nat Commun
; 14(1): 5284, 2023 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37723151
11.
Soluble organic molecules in samples of the carbonaceous asteroid (162173) Ryugu.
Science
; 379(6634): eabn9033, 2023 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36821691
12.
Polycyclic aromatic hydrocarbons in samples of Ryugu formed in the interstellar medium.
Science
; 382(6677): 1411-1416, 2023 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38127762
13.
Structure based design of iminohydantoin BACE1 inhibitors: identification of an orally available, centrally active BACE1 inhibitor.
Bioorg Med Chem Lett
; 22(7): 2444-9, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22390835
14.
Identification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexes.
Biochemistry
; 50(22): 4973-80, 2011 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21528914
15.
Prebiotic synthesis of methionine and other sulfur-containing organic compounds on the primitive Earth: a contemporary reassessment based on an unpublished 1958 Stanley Miller experiment.
Orig Life Evol Biosph
; 41(3): 201-12, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21063908
16.
Enhanced synthesis of alkyl amino acids in Miller's 1958 H2S experiment.
Orig Life Evol Biosph
; 41(6): 569-74, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22139514
17.
Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization.
Bioorg Med Chem Lett
; 20(9): 2837-42, 2010 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20347593
18.
A sensitive quantitative analysis of abiotically synthesized short homopeptides using ultraperformance liquid chromatography and time-of-flight mass spectrometry.
J Chromatogr A
; 1630: 461509, 2020 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32927393
19.
Generation of Leads for γ-Secretase Modulation.
J Med Chem
; 63(15): 8216-8230, 2020 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32786237
20.
Characterization of the potent and highly selective A2A receptor antagonists preladenant and SCH 412348 [7-[2-[4-2,4-difluorophenyl]-1-piperazinyl]ethyl]-2-(2-furanyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine] in rodent models of movement disorders and depression.
J Pharmacol Exp Ther
; 330(1): 294-303, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19332567