An insight into predatory journals.

The impact of scholarly journals has increased with invent of Internet due to improved access, faster dissemination, and ease of searching a variety of publications. With the increasing trend of research, open access (OA) publishing has increased intensely over the last few years. The core intent of OA is faster dissemination of research by making it available to readers free of cost. However, some publishers exploited this novel idea for their own benefit. Beall termed them as predatory publishers/journals. In this article, authors have made efforts to understand the predatory publishers/journal, reasons behind their upsurge, their modus operandi, their common targets, and the points which will help readers to identify them. The aim of this article is to expose facts behind the predatory journal and to create awareness among not only budding researchers but also faculty members, authors, and editors about the threat predatory journals carry toward scientific world and to their own curricula.

Havoc of dental quacks in a district in India: A case series.

A "quack" is defined as "a fraudulent or ignorant pretender to medical skill or a person who pretends, professionally or publicly, to have skill, knowledge, or qualifications he or she does not possess." A number of dental quacks are practicing roadside, making money by doing unethical and unhygienic practice, eventually, hampering the patient's oral and general health. Common quackery practices carried out in India are filling of teeth with acrylic resin, fixing the removable partial denture as fixed partial denture using wires and self-curing acrylic resin, using suction disc on the palatal surface of complete denture to improve retention, etc., leading to a number of unfortunate consequences. In this study, we present a case series of mal-treatments performed by different quacks in Dhule district of Maharashtra (India).

Intensified summer monsoon and the urbanization of Indus Civilization in northwest India.

Today the desert margins of northwest India are dry and unable to support large populations, but were densely occupied by the populations of the Indus Civilization during the middle to late Holocene. The hydroclimatic conditions under which Indus urbanization took place, which was marked by a period of expanded settlement into the Thar Desert margins, remains poorly understood. We measured the isotopic values (δ18O and δD) of gypsum hydration water in paleolake Karsandi sediments in northern Rajasthan to infer past changes in lake hydrology, which is sensitive to changing amounts of precipitation and evaporation. Our record reveals that relatively wet conditions prevailed at the northern edge of Rajasthan from ~5.1 ± 0.2 ka BP, during the beginning of the agricultural-based Early Harappan phase of the Indus Civilization. Monsoon rainfall intensified further between 5.0 and 4.4 ka BP, during the period when Indus urban centres developed in the western Thar Desert margin and on the plains of Haryana to its north. Drier conditions set in sometime after 4.4 ka BP, and by ~3.9 ka BP an eastward shift of populations had occurred. Our findings provide evidence that climate change was associated with both the expansion and contraction of Indus urbanism along the desert margin in northwest India.

Author Correction: Intensified summer monsoon and the urbanization of Indus Civilization in northwest India.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.

Polyethylenimine nanoparticles as efficient transfecting agents for mammalian cells.

Two cross-linkers based on polyethylene glycol (PEG) (MW=6 and 8 kDa), were synthesized for self-assembling and formation of nanoparticles of branched, high molecular weight polyethylenimine (PEI). Cross-linking was realized in two ways, viz., ionic as well as covalent. Ionic cross-linking was accomplished by using PEG-bis (phosphate) whereas, the covalent one was achieved by using PEG-bis (p-nitrophenylcarbonate). A range of nanoparticles of PEI was prepared by varying the degree of cross-linking (i.e. the amount of cross-linkers used). PEI-PEG nanoparticles were characterized by dynamic light scattering and transmission electron microscopy and found to be in the range of approximately 18-75 nm (hydrodynamic radii) with almost uniform population. Subsequently, these particles were used for DNA binding assay and zeta-potential measurements, taking native PEI-PEG nanoparticles as reference. As expected, the zeta potential values decreased, on increasing the percentage of cross-linking as well as on complexation with DNA. Further, PEI-PEG nanoparticles were investigated for their transfecting efficacy on COS-1 cells. It was found that PEI-PEG nanoparticles were 5- to 16-fold more efficient as transfecting agents compared to lipofectin and PEI itself. The toxicity of PEI-PEG nanoparticles was found to be reduced considerably in comparison to PEI polymer, as determined by MTT colorimetric assay. Out of the various systems prepared, PEI-PEG8000 (5% ionic) nanoparticles were found to be the most efficient transfecting agent for in vitro transfection.

Investigation of processes in black tea manufacture through model fermentation (oxidation) experiments.

Flavanol depleted whole fresh green tea leaf powder, as reported in the literature, was used as matrix for a systematic study of the endogenous oxidative enzymatic conversion of selected flavanol combinations to theaflavins and thearubigins. The activity of the two crucial enzymes polyphenol oxidase (PPO) and peroxidase (POD) was controlled individually through addition of H2O2 and/or O2. Using the endogenous peroxidase only it was shown that (-)-epicatechin alone did not react with POD. According to these results it is possible that theaflavin formation occurs via reaction of a flavanol quinone with a nonquinone flavanol. It was confirmed that only a dihydroxy-B-ring flavanol with a trihydroxy-B-ring flavanol gave a theaflavin upon enzymatic oxidation. Use of horseradish peroxidase in the presence of a flavanol depleted tea leaf matrix led to significantly higher kinetics on theaflavin 3-gallate degradation compared to the absence of leaf matrix, suggesting a catalytic effect of the leaf matrix not reported before.

Scientific validation of the ethnomedicinal properties of the Ayurvedic drug Triphala: a review.

Triphala, a herbal formula composed of the three fruits of Terminalia chebula Retz. (Haritaki, Family: Combretaceae), Terminalia bellirica Roxb. (Bibhitaki, Family: Combretaceae) and Phyllanthus emblica Linn. or Emblica officinalis Gaertn. (Amalaki or the Indian gooseberry, Family: Euphorbiaceae) is considered to be a universal panacea in the traditional Indian system of medicine the Ayurveda. It has been described in the Ayurveda text as a "Rasayana' and to rejuvenat the debilitated organs. Ayurvedic physicians use Triphala for many ailments but most importantly to treat various gastrointestinal disorders. Scientific studies carried out in the past two decades have validated many of the ethnomedicinal claims and researches have shown Triphala to possess free radical scavenging, antioxidant, antiinflammatory, antipyretic, analgesic, antibacterial, antimutagenic, wound healing, anticariogenic, antistress, adaptogenic, hypoglycaemic, anticancer, chemoprotective, radioprotective and chemopreventive effects. Clinical studies have also shown that Triphala was found to have good laxative property, to improve appetite and reduce gastric hyperacidity. Studies have also shown that Triphala was effective in preventing dental caries and that this effect was equal to that of chlorhexidine. The current review addresses the validated pharmacological properties of Triphala and also emphasizes on aspects that need further investigation for its future clinic application.

Development of a gas chromatography method for the estimation of alkylamines in foods.

Alkylamines are gaining importance due to their proven immunity benefits. Fruits, vegetables, and beverages are important dietary sources for alkylamines. This paper reports for the first time quantitative data on four alkylamines, ethyl-, propyl-, isopropyl-, and sec-butylamines, in commonly consumed fruits and vegetables. A sensitive and selective chromatography method based on derivatization with pentafluorobenzaldehyde and detection by GC-ECD is developed and validated for the analysis of alkylamines in vegetables, fruits, and tea. In vegetables and fruits, the concentrations varied from 100 to 15,000 µg/kg. Propyl- and isopropylamine concentrations were significantly higher compared to other amines. Among all dietary sources, tea had the highest concentration of alkylamines (30-50 mg/kg), with ethylamine as the major component, and is the richest source for alkylamines. The stability of these alkylamines was studied under various cooking conditions, and it was observed that there is loss of alkylamines on cooking.