Detalhe da pesquisa
1.
The M1 muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes.
Proc Natl Acad Sci U S A
; 119(24): e2201103119, 2022 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35671422
2.
Chemokine receptor CXCR4 oligomerization is disrupted selectively by the antagonist ligand IT1t.
J Biol Chem
; 296: 100139, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33268380
3.
A general method to quantify ligand-driven oligomerization from fluorescence-based images.
Nat Methods
; 16(6): 493-496, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31110281
4.
Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor.
Biochem J
; 474(11): 1879-1895, 2017 05 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28424368
5.
Multiple AMPK activators inhibit l-carnitine uptake in C2C12 skeletal muscle myotubes.
Am J Physiol Cell Physiol
; 312(6): C689-C696, 2017 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28298333
6.
Dynamic Regulation of Quaternary Organization of the M1 Muscarinic Receptor by Subtype-selective Antagonist Drugs.
J Biol Chem
; 291(25): 13132-46, 2016 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-27080256
7.
Regulation of oligomeric organization of the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor observed by spatial intensity distribution analysis.
J Biol Chem
; 290(20): 12844-57, 2015 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25825490
8.
Roundabout 1 exists predominantly as a basal dimeric complex and this is unaffected by binding of the ligand Slit2.
Biochem J
; 461(1): 61-73, 2014 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24673457
9.
The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism.
Mol Pharmacol
; 84(5): 710-25, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23979972
10.
Intramolecular fluorescence resonance energy transfer (FRET) sensors of the orexin OX1 and OX2 receptors identify slow kinetics of agonist activation.
J Biol Chem
; 287(18): 14937-49, 2012 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22389503
11.
Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4).
J Biol Chem
; 287(20): 16656-69, 2012 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-22411985
12.
Heteromultimerization of cannabinoid CB(1) receptor and orexin OX(1) receptor generates a unique complex in which both protomers are regulated by orexin A.
J Biol Chem
; 286(43): 37414-28, 2011 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-21908614
13.
The orexin OX(1) receptor exists predominantly as a homodimer in the basal state: potential regulation of receptor organization by both agonist and antagonist ligands.
Biochem J
; 439(1): 171-83, 2011 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21770891
14.
Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a receptor activated solely by synthetic ligand (RASSL).
Mol Pharmacol
; 80(6): 1033-46, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21880827
15.
Ligand regulation of the quaternary organization of cell surface M3 muscarinic acetylcholine receptors analyzed by fluorescence resonance energy transfer (FRET) imaging and homogeneous time-resolved FRET.
J Biol Chem
; 285(30): 23318-30, 2010 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-20489201
16.
Applications of fluorescence and bioluminescence resonance energy transfer to drug discovery at G protein coupled receptors.
Anal Bioanal Chem
; 398(1): 167-80, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20517598
17.
Agonist occupancy of a single monomeric element is sufficient to cause internalization of the dimeric beta2-adrenoceptor.
Cell Signal
; 19(9): 1928-38, 2007 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-17561373
18.
Spatial Intensity Distribution Analysis: Studies of G Protein-Coupled Receptor Oligomerisation.
Trends Pharmacol Sci
; 39(2): 175-186, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29032835
19.
Visualization of the activation of the histamine H3 receptor (H3R) using novel fluorescence resonance energy transfer biosensors and their potential application to the study of H3R pharmacology.
FEBS J
; 285(12): 2319-2336, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29701013
20.
A Molecular Basis for Selective Antagonist Destabilization of Dopamine D3 Receptor Quaternary Organization.
Sci Rep
; 7(1): 2134, 2017 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28522847