Detalhe da pesquisa
1.
Identification and SAR of novel pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1).
Bioorg Med Chem Lett
; 20(3): 1094-9, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20031401
2.
Dihydroxy-pyrimidine and N-methylpyrimidone HIV-integrase inhibitors: improving cell based activity by the quaternarization of a chiral center.
Bioorg Med Chem Lett
; 19(16): 4617-21, 2009 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19616948
3.
A novel series of potent and selective ketone histone deacetylase inhibitors with antitumor activity in vivo.
J Med Chem
; 51(8): 2350-3, 2008 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-18370373
4.
Design and synthesis of bicyclic pyrimidinones as potent and orally bioavailable HIV-1 integrase inhibitors.
J Med Chem
; 51(4): 861-74, 2008 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-18217703
5.
Optimization of a series of potent and selective ketone histone deacetylase inhibitors.
Bioorg Med Chem Lett
; 18(20): 5528-32, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18809328
6.
Discovery and synthesis of HIV integrase inhibitors: development of potent and orally bioavailable N-methyl pyrimidones.
J Med Chem
; 50(20): 4953-75, 2007 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-17824681
7.
Discovery of a potent class I selective ketone histone deacetylase inhibitor with antitumor activity in vivo and optimized pharmacokinetic properties.
J Med Chem
; 52(11): 3453-6, 2009 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-19441846
8.
Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection.
J Med Chem
; 51(18): 5843-55, 2008 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-18763751
9.
Tetrazole thioacetanilides: potent non-nucleoside inhibitors of WT HIV reverse transcriptase and its K103N mutant.
Bioorg Med Chem Lett
; 16(10): 2748-52, 2006 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16503141