Detalhe da pesquisa
1.
Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis.
J Med Chem
; 63(8): 3868-3880, 2020 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31940200
2.
Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH).
J Med Chem
; 60(24): 9960-9973, 2017 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29148806
3.
Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials.
J Med Chem
; 56(14): 5675-90, 2013 Jul 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-23742252
4.
Developmental exposure to polychlorinated biphenyls interferes with experience-dependent dendritic plasticity and ryanodine receptor expression in weanling rats.
Environ Health Perspect
; 117(3): 426-35, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19337518
5.
Conformation-dependent stability of junctophilin 1 (JP1) and ryanodine receptor type 1 (RyR1) channel complex is mediated by their hyper-reactive thiols.
J Biol Chem
; 282(12): 8667-77, 2007 Mar 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-17237236
6.
In situ naphthalene bioactivation and nasal airflow cause region-specific injury patterns in the nasal mucosa of rats exposed to naphthalene by inhalation.
J Pharmacol Exp Ther
; 314(1): 103-10, 2005 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15833892
7.
Consequences of abrupt glutathione depletion in murine Clara cells: ultrastructural and biochemical investigations into the role of glutathione loss in naphthalene cytotoxicity.
J Pharmacol Exp Ther
; 314(2): 506-13, 2005 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-15845860
8.
Detection of viral infection in the respiratory tract of virus antibody free mice: advantages of high-resolution imaging for respiratory toxicology.
Toxicol Appl Pharmacol
; 190(3): 286-93, 2003 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12902200