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1.
Urol Int ; 108(3): 226-233, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38368856

RESUMO

INTRODUCTION: The main challenge to the optimal use of neoadjuvant chemotherapy (NAC) is the difficulty in selecting patients who may or may not benefit from NAC. Our aim in this study was to investigate whether the Systemic Inflammatory Index (SII) predicts response to chemotherapy in patients who receive NAC prior to cystectomy. METHODS: We retrospectively analysed the data of patients who underwent NAC followed by cystectomy at our institution between January 2010 and September 2015 and whose 5-year follow-up was completed. All patients who underwent diagnostic biopsy with complete transurethral resection of bladder tumour at our hospital and whose pathology result was muscle-invasive transitional cell carcinoma were included in the study. At least 3 courses of gemcitabine/cisplatin NAC were given to all patients. A pathological response was defined as a reduction in cystectomy to a lower pathological stage after NAC. RESULTS: The SII was 320.8 ± 51 in the responders and 388.28 ± 50 in the non-responders. SII optimal cut-off of 350 was determined. The sensitivity and specificity of SII in predicting response were found to be 80% and 83%, respectively. Low SII (<350) was found to be a significant predictor of response compared with the other factors on multivariate analysis. The mean overall survival time was 55.4 months in patients with a low SII value and 40.3 months in the high SII group. CONCLUSION: SII, together with known clinicopathological factors and newer genetic and molecular markers, can be used to select patients for NAC.


Assuntos
Carcinoma de Células de Transição , Cistectomia , Terapia Neoadjuvante , Neoplasias da Bexiga Urinária , Humanos , Neoplasias da Bexiga Urinária/tratamento farmacológico , Neoplasias da Bexiga Urinária/cirurgia , Neoplasias da Bexiga Urinária/patologia , Cistectomia/métodos , Masculino , Estudos Retrospectivos , Feminino , Idoso , Pessoa de Meia-Idade , Carcinoma de Células de Transição/tratamento farmacológico , Carcinoma de Células de Transição/cirurgia , Carcinoma de Células de Transição/patologia , Carcinoma de Células de Transição/terapia , Resultado do Tratamento , Inflamação , Quimioterapia Adjuvante , Valor Preditivo dos Testes , Gencitabina , Cisplatino/uso terapêutico , Cisplatino/administração & dosagem , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Desoxicitidina/análogos & derivados , Desoxicitidina/uso terapêutico , Desoxicitidina/administração & dosagem
2.
Aesthetic Plast Surg ; 2024 Jul 10.
Artigo em Inglês | MEDLINE | ID: mdl-38987315

RESUMO

BACKGROUND: Ozone is often used as an additive therapy for skin conditions like infectious diseases, wound healing, diabetic foot, and pressure ulcers. The viability of the nasal skin has crucial importance in revision rhinoplasty cases. The study investigates the potential benefits of medical ozone therapy in healing the nasal skin in multiple-operated cases. METHODS: The study retrospectively examined 523 revision rhinoplasty patients operated by the first author from January 2017 to January 2024. Patients consenting to ozone therapy received 3 major autohemotherapy sessions post-surgery. Patients were divided into 2 groups: those with compromised nasal skin (infection, poor vascular supply) and those with normal healing. Age, gender, smoking, diabetes, previous surgeries, grafting materials, and techniques were considered. RESULTS: Of the 523 patients, 12 (2.3%) experienced major skin complications like infection and necrosis, while 511 (97.7%) had no or minor issues, such as discoloration. In total, 301 patients accepted and received ozone therapy. Of the patients without major complications, 299 (58.3%) received ozone therapy, while 212 (41.7%) did not. Among the 12 with major complications, two (16.7%) received ozone therapy, and the remaining 10 (83.3%) did not. Ozone therapy recipients showed statistically fewer skin problems (p<0.05). Costal cartilage as tip and septal extension graft was linked to skin issues (p<0.05). No major adverse effects from ozone therapy were noted. CONCLUSIONS: Our findings indicate that ozone therapy may be a safe and potentially effective option for patients undergoing revision rhinoplasty, especially those with compromised nasal skin. It appears to aid in skin healing and regeneration, possibly through enhancing oxygen delivery and modulation of the immune response. Ozone therapy is a promising adjunct treatment for managing skin complications in revision rhinoplasty patients. LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

3.
Clin Otolaryngol ; 49(6): 742-747, 2024 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-38982800

RESUMO

OBJECTIVES: Insulin resistance is associated with increased levels of IGF-1. IGF-1 has been shown to increase the risk of laryngeal squamous cell carcinoma. The Triglyceride-glucose index (TyG index) is a marker of insulin resistance. Our study aimed to investigate the relationship between the TyG index and laryngeal squamous cell carcinoma. DESIGN: Retrospective cohort study. SETTING: Two tertiary care academic hospitals. METHODS: The study included 53 patients with laryngeal squamous cell carcinoma (Group 1) and 48 healthy volunteers (Group 2). Laryngeal cancer patients were divided into two groups according to their stage. Stages I and II were named Group 1A, and Stages III and IV were called Group 1B. The TyG index was calculated as ln [fasting Triglycerides (mg/dL) × fasting plasma glucose (mg/dL)/2]. The effect of the TyG index on laryngeal cancer was investigated on the parameters of sex, age, body mass index, and stage of the disease. RESULTS: There were no significant differences in age, sex, and BMI between the groups. The TyG index of group 1 (4.75 ± 0.33) was significantly higher than that of group 2 (4.59 ± 0.15). The TyG index value of group 1B (4.84 ± 0.31) was significantly higher than both group 1A (4.61 ± 0.32) and group 2 (4.59 ± 0.15). There was no significant difference between the TyG index values of group 1A (4.61 ± 0.32) and group 2 (4.59 ± 0.15). CONCLUSION: The TyG index may be a promising laryngeal squamous cell carcinoma biomarker. People with a higher TyG index may have a higher incidence of laryngeal squamous cell carcinoma and a higher risk of progression.


Assuntos
Glicemia , Carcinoma de Células Escamosas , Neoplasias Laríngeas , Triglicerídeos , Humanos , Masculino , Neoplasias Laríngeas/sangue , Feminino , Estudos Retrospectivos , Pessoa de Meia-Idade , Triglicerídeos/sangue , Carcinoma de Células Escamosas/sangue , Carcinoma de Células Escamosas/diagnóstico , Fatores de Risco , Glicemia/metabolismo , Glicemia/análise , Idoso , Resistência à Insulina , Biomarcadores Tumorais/sangue , Estadiamento de Neoplasias , Adulto , Biomarcadores/sangue
4.
Am J Otolaryngol ; 44(4): 103817, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36905778

RESUMO

OBJECTIVE: The aim of this study is to demonstrate a novel surgical technique in the treatment of lower lateral crural protrusion and external nasal valve pinching. METHOD: The lower lateral crural resection technique was used in 24 patients who underwent open technique septorhinoplasty between 2019 and 2022. Fourteen of the patients were female and 10 were male. In this technique, excess part of crura's tail was excised from the lower lateral crura and placed in the same pocket. This area was supported with a diced cartilage and a postoperative nasal retainer was applied. We have corrected the aesthetic problem that occurs when the lower lateral cartilage is convex, and external nasal valve pinching that occurs when the lower lateral crural protrusion is concave. RESULT: The mean age of the patients was 23. The mean follow-up time of the patients was between 6 and 18 months. No complications were observed due to this technique. Satisfactory results were obtained in the postoperative period after surgery. CONCLUSION: A new surgical approach has been proposed for patients with lower lateral crural protrusion and external nasal valve pinching using the lateral crural resection technique.


Assuntos
Nariz , Rinoplastia , Humanos , Masculino , Feminino , Nariz/cirurgia , Cartilagem/cirurgia , Rinoplastia/métodos , Estética , Retalhos Cirúrgicos , Cartilagens Nasais/cirurgia
5.
Aesthetic Plast Surg ; 2023 Nov 09.
Artigo em Inglês | MEDLINE | ID: mdl-37945761

RESUMO

OBJECTIVE: This study aims to demonstrate a new surgical technique that can be applied in patients with cephalic malposition and patients with alar retraction. METHODS: In this technique, a cartilage incision is made between the upper 2/3 and lower 1/3 close to the caudal edge and parallel to the cephalic edge of the lateral crus. Following this incision, the cephalic lateral crus and middle crus are meticulously dissected away from the underlying vestibular skin. The prepared flap is transposed over the intact caudal part of the lateral crus and secured in position. RESULTS: The average age of the patients included in the study was 24 years. The mean follow-up period was nine months, ranging from 6 to 12 months. No complications were observed following the application of the technique. Satisfactory outcomes were achieved postoperatively. CONCLUSION: Lateral overlay sliding transposition as a novel surgical technique has been demonstrated in patients presenting with cephalic malposition, mild to moderate alar retraction, and alar irregularity. LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

6.
Int J Clin Pract ; 75(12): e14873, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34525243

RESUMO

AIM: To assess the functions of the lower urinary tract (LUT) in patients with myasthenia gravis (MG). MATERIALS AND METHODS: A total of 36 patients (18 males and 18 females) with MG and 29 healthy controls were enrolled. Participants completed a 3-day voiding diary and responded to questionnaires "Overactive Bladder Symptom Score" (OABSS) and "International Consultation on Incontinence-Short Form" (ICIQ-SF). All patients underwent uroflowmetry and ultrasonography (US). The data were compared based on the onset of disease and serological status. RESULTS: The most common urinary symptoms were nocturia (80.5%), incontinence (61%) and urgency (47%). OABSS was higher in patients than controls (P = .008). Duration of urinary symptoms was longer, and nocturia was more common in late-onset MG (LOMG) than in early-onset MG (EOMG; P = .029, P = .023). The duration of disease and urinary symptoms statistically increased in ACh-Ab (-) group compared with ACh-Ab (+) group (P = .003, P = .027). Night-time urination frequency significantly increased while daytime voided volume (VV) decreased in LOMG compared with EOMG (P = .003 and P = .01). Residual volume on the US was significantly higher in LOMG than that in EOMG (P = .004). The duration of disease was positively correlated with tQmax and daytime urination frequency (P = .013, r = .48; P = .016, r = .398). A negative association was found between duration of disease and daytime VV (P = .04, r = -.344). CONCLUSION: LUT dysfunction may manifest disease in MG, particularly in late-onset forms. The lack of ACh-Ab seemed to prolong the duration of disease and urinary disturbances.


Assuntos
Sintomas do Trato Urinário Inferior , Miastenia Gravis , Noctúria , Bexiga Urinária Hiperativa , Feminino , Humanos , Masculino , Miastenia Gravis/complicações , Inquéritos e Questionários , Bexiga Urinária , Micção
7.
Aging Male ; 23(5): 533-537, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30468407

RESUMO

INTRODUCTION: Transurethral resection of the prostate (TURP) is the gold standard method for surgical treatment of benign prostatic hyperplasia (BPH). So, the complications of TURP is important, in which erectile dysfunction is the most important. The aim of the present study is to evaluate erectile dysfunction in patients undergoing TURP treatment for BPH and investigate the correlation between metabolic syndrome and erectile dysfunction. MATERIALS AND METHODS: This study included 120 patients who underwent surgery for BPH at Beylikdüzü State Hospital and Okmeydani Training and Research Hospital. IIEF-5 form was administered to the patients before the surgery and six months after the surgery. The Student's t-test, Wilcoxon, and chi-square test were used in the statistical analysis. RESULTS: The patients were investigated by IIEF-5 scoring into three groups (severe, moderate, and non-ED (erectyl disfunction)-mild). The statistical analysis of IIEF-5 form administered to 120 patients who underwent surgery did not show any significant difference before surgery and six months after surgery (p > 0.05). Metabolic syndrome and erectile dysfunction correlation were examined, and a significant correlation was obtained between metabolic syndrome and severe erectile dysfunction (p < 0.05). CONCLUSIONS: IIEF-5 results administered before and after surgery showed no significant difference. The study showed that patients with metabolic syndrome have a higher probability of having erectile dysfunction after TURP compared to patients without metabolic syndrome. Moreover, post-surgery, patients with metabolic syndrome seemed to be affected negatively regarding erectile dysfunction compared to patients with no metabolic syndrome.


Assuntos
Disfunção Erétil , Síndrome Metabólica , Hiperplasia Prostática , Ressecção Transuretral da Próstata , Disfunção Erétil/etiologia , Humanos , Masculino , Síndrome Metabólica/complicações , Ereção Peniana , Hiperplasia Prostática/complicações , Hiperplasia Prostática/cirurgia , Ressecção Transuretral da Próstata/efeitos adversos
8.
Aging Male ; 23(5): 538-543, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30463466

RESUMO

OBJECTIVE: To compare the efficacy of statins and ɑ blockers drug therapies for benign prostatic hyperplasia (BPH) in patients with metabolic syndrome (MetS). MATERIALS AND METHOD: A total of three hundred patients were randomly distributed into three groups of one hundred patients each. Group 1 received only ɑ-adrenoceptor antagonist (ɑ-blocker, AB) (Tamsulosin), group 2 received only statin (atorvastatin), and group 3 received AB plus statin (Tamsulosin + Atorvastatin). The efficacy measurement was assessed by analyzing the changes from baseline in the total International Prostate Symptom Score (IPSS), disease-specific QoL question score and maximum urinary flow rate at the end of 6 months in each group and between the three groups. RESULTS: Pre-treatment and post-treatment value of triglycerides (TG), high-density lipoprotein (HDL), and prostate volüme (PV) were not significantly different in AB group, while TG and PV were significantly lower in patients taking statin and combined therapy. The significant decrease was demonstrated in maximum urinary flow rate (Qmax) in three groups. However, the most significant decrease was observed in the combination therapy group. IPSS, postvoid residual urine volüme (PVR), and Quality of Life score (QoL) significantly changed in three groups. CONCLUSION: We recommend of the use of statins in those men with BPH accompanied by MetS in which AB is ineffective alone.


Assuntos
Inibidores de Hidroximetilglutaril-CoA Redutases , Síndrome Metabólica , Hiperplasia Prostática , Humanos , Inibidores de Hidroximetilglutaril-CoA Redutases/uso terapêutico , Masculino , Síndrome Metabólica/complicações , Síndrome Metabólica/tratamento farmacológico , Hiperplasia Prostática/complicações , Hiperplasia Prostática/tratamento farmacológico , Qualidade de Vida , Sulfonamidas , Resultado do Tratamento
9.
Aging Male ; 21(3): 206-210, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-29338524

RESUMO

OBJECTIVE: Visceral adiposity index (VAI) is a novel indicator for the assessment of visceral obesity. In this study, we aimed to evaluate the relationship between VAI and premature ejaculation (PE). MATERIALS AND METHOD: A total of 300 men were included in the study. Hundred and fifty men with PE and 150 men without PE (control). All men were evaluated for PE by premature ejaculation diagnostic tool (PEDT). VAI levels were calculated using body mass index (BMI), high density lipoprotein and triglyceride (TG) levels. RESULTS: Mean age of the study groups was 34.3 ± 5.2 (30-60) years and the mean age of the controls were 35.9 ± 5.3 (30-60) years. The men with PE had lower BMI, TG levels, waist circumference (WC) and higher high-density lipoprotein-cholesterol (HDL-C) levels. Mean VAI level was 4.13 ± 0.7 in study group and 5.72 ± 1.6 in control group, respectively. VAI levels were statistically higher in men without PE (p < .001). DISCUSSION: Our cross-sectional study demonstrated a negative correlation between VAI and PE. VAI is superior index for the evaluation and calculation the relationship between obesity and PE.


Assuntos
Gordura Intra-Abdominal/fisiopatologia , Obesidade Abdominal/complicações , Ejaculação Precoce/complicações , Adulto , Índice de Massa Corporal , Estudos de Casos e Controles , HDL-Colesterol/sangue , Estudos Transversais , Humanos , Masculino , Pessoa de Meia-Idade , Ejaculação Precoce/sangue , Ejaculação Precoce/fisiopatologia , Estudos Prospectivos , Inquéritos e Questionários , Triglicerídeos/sangue , Circunferência da Cintura
10.
Int Braz J Urol ; 44(6): 1243-1251, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30130014

RESUMO

INTRODUCTION: We investigated whether Oltipraz (OPZ) attenuated renal fibrosis in a unilateral ureteral obstruction (UUO) rat model. MATERIALS AND METHODS: We randomly divided 32 rats into four groups, each consisting of eight animals as follows: Rats in group 1 underwent a sham operation and received no treatment. Rats in group 2 underwent a sham operation and received OPZ. Rats in group 3 underwent unilateral ureteral ligation and received no treatment. Group 4 rats were subjected to unilateral ureteral ligation plus OPZ administration. Transforming growth factor beta-1 (TGF-ß1), E-cadherin, nitric oxide (NO) and hydroxyproline levels were measured. Histopathological and immunohistochemical examinations were carried out. RESULTS: TGF-ß1, NO and E-cadherin levels in the UUO group were significantly higher than the sham group and these values were significantly different in treated groups compared to the UUO group. In rats treated with UUO + OPZ, despite the presence of mild tubular degeneration and less severe tubular necrosis, glomeruli maintained a better morphology when compared to the UUO group. Expressions of α-SMA in immunohistochemistry showed that the staining positivity decreased in the tubules of the OPZ-treated group. CONCLUSIONS: While the precise mechanism of action remains unknown, our results demonstrated that OPZ exerted a protective role in the UUO-mediated renal fibrosis rat model highlighting a promising therapeutic potency of Nrf2-activators for alleviating the detrimental effects of unilateral obstruction in kidneys.


Assuntos
Nefropatias/tratamento farmacológico , Fator 2 Relacionado a NF-E2/uso terapêutico , Pirazinas/uso terapêutico , Obstrução Ureteral/complicações , Animais , Caderinas/sangue , Modelos Animais de Doenças , Fibrose/tratamento farmacológico , Fibrose/etiologia , Hidroxiprolina/sangue , Imuno-Histoquímica , Nefropatias/etiologia , Nefropatias/patologia , Masculino , Óxido Nítrico/sangue , Ratos , Ratos Wistar , Tionas , Tiofenos , Fator de Crescimento Transformador beta1/sangue , Obstrução Ureteral/tratamento farmacológico , Obstrução Ureteral/patologia
11.
Urol Int ; 98(2): 210-214, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-27160247

RESUMO

PURPOSE: In this study, we evaluated the effect of 5 mg tadalafil once daily in men with premature ejaculation (PE). METHODS: Thirty married men with lifelong PE and 30 healthy men as control group were included in this study. All the patients received 5 mg tadalafil once a day for a month. The international index of erectile function questionnaire and intravaginal ejaculatory latency times (IELTs) and PE profile were recorded before and after treatment. Plasma samples were collected before and after treatment. RESULTS: The mean baseline IELTs was 40.8 ± 8.1 s in the PE group and 196.5 ± 26.2 s in the control group. After treatment in the PE group, the mean IELTs values showed a statistically significant improvement from the baseline values. At the end of 4 weeks, in the PE group, the mean IELT values showed a statistically significant improvement from the baseline values. Baseline serum nitric oxide (NO) levels were 27.3 ± 1.7 in the PE group and in the 31.1 ± 1.4 healthy control groups. After treatment, NO levels were increased from baseline. CONCLUSION: We consider that 5 mg tadalafil once daily is safety and effective for the treatment of PE.


Assuntos
Ejaculação Precoce/tratamento farmacológico , Tadalafila/administração & dosagem , Agentes Urológicos/administração & dosagem , Adulto , Carbolinas , Estudos de Casos e Controles , Esquema de Medicação , Ejaculação , Humanos , Masculino , Pessoa de Meia-Idade , Óxido Nítrico/sangue , Índice de Gravidade de Doença , Inquéritos e Questionários , Resultado do Tratamento
12.
Arch Ital Urol Androl ; 89(1): 26-30, 2017 Mar 31.
Artigo em Inglês | MEDLINE | ID: mdl-28403591

RESUMO

OBJECTIVE: We evaluated the correlation between benign prostate hyperplasia (BPH) measures and diabetes mellitus in men with benign prostate hyperplasia in a prospective study. MATERIALS AND METHODS: Between 2008-2012, 100 diabetic and 200 non diabetic patients undergoing surgery due to benign prostate hyperplasia were enrolled in the study. The parameters evaluated for each patients included prostate volume, fasting blood glucose, HbA1c, total testosterone, total prostatic specific antigen (T-PSA), triglicerides, total cholesterol and body mass index (BMI). A questionnaire including international prostate symptom score (IPSS) was sdministered and uroflow test measuring the peak urinary flow rate was performed to appreciate the complaints of the patients objectively. RESULTS: Diabetic patients are more likely to have larger prostate volume. The symptom score evaluated by IPSS and post micturition residual volume were also significantly higher in diabetic groups. The other statistically significant different parameter between two groups was total testosterone that diabetic patients tend to have lower levels. Diabetic counterparts were established to have higher BMI. No statistically significant differentiation was observed about trigliceryde and total cholesterol levels and uroflow rates. CONCLUSIONS: Our study suggests a positive correlation between high prostate volume and diagnosis of diabetes mellitus in patients with benign prostatic hyperplasia. We also observed a positive correlation between symptom scores and post micturion residual volumes and diagnosis of diabetes mellitus suggesting that the presence of diabetes is related to both static and dynamic components of benign prostate hyperplasia. Additionally testosterone levels were lower in diabetic patients. Further studies need to confirm these relationship in a larger population.


Assuntos
Diabetes Mellitus/epidemiologia , Antígeno Prostático Específico/sangue , Hiperplasia Prostática/patologia , Triglicerídeos/sangue , Idoso , Glicemia/metabolismo , Índice de Massa Corporal , Colesterol/sangue , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Inquéritos e Questionários , Testosterona/sangue , Micção/fisiologia
13.
Opt Lett ; 40(9): 1984-7, 2015 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-25927764

RESUMO

In this Letter, we demonstrate a broadband terahertz (THz) spatial light modulator using 5×5 arrays of large area graphene supercapacitors. Our approach relies on controlling spatial charge distribution on a passive matrix array of patterned graphene electrodes. By changing the voltage bias applied to the rows and columns, we were able to pattern the THz transmittance through the device with high modulation depth and low operation voltage. We anticipate that the simplicity of the device architecture with high contrast THz modulation over a broad spectral range could provide new tools for THz imaging and communication systems.


Assuntos
Eletricidade , Grafite , Luz , Radiação Terahertz , Eletrodos
14.
J Sex Marital Ther ; 41(4): 440-9, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-24824329

RESUMO

Female sexual dysfunction is a prevalent and multidimensional disorder related to many biological, psychological, and social determinants. The authors assessed the effect of one of the many factors affect sexual function-metabolic syndrome-on female sexual function. They equally divided 400 women participants among 4 groups: (a) premenopausal with metabolic syndrome, (b) premenopausal without metabolic syndrome, (c) postmenopausal with metabolic syndrome, and (d) postmenopausal without metabolic syndrome. The authors used the Female Sexual Function Index to assess women's sexual function. Female sexual dysfunction was found more often in both pre- and postmenopausal women with metabolic syndrome (p =.001). Overall Female Sexual Function Index score and satisfaction, pain, and desire domain scores independently of the menopause status showed statistically significant differences across women with metabolic syndrome in comparison with participants with no metabolic syndrome (p <.05). The authors also evaluated the associations among 5 components of metabolic syndrome and Female Sexual Function Index scores. Higher fasting glucose levels were significantly associated with the Female Sexual Function Index score (p <.05). This study shows that sexual dysfunction is more prevalent in pre- and postmenopausal women with the metabolic syndrome.


Assuntos
Síndrome Metabólica/epidemiologia , Síndrome Metabólica/psicologia , Pós-Menopausa/psicologia , Pré-Menopausa/psicologia , Disfunções Sexuais Fisiológicas/epidemiologia , Disfunções Sexuais Fisiológicas/psicologia , Adulto , Glicemia/metabolismo , Estudos Transversais , Feminino , Humanos , Síndrome Metabólica/fisiopatologia , Pessoa de Meia-Idade , Orgasmo/fisiologia , Pós-Menopausa/fisiologia , Pré-Menopausa/fisiologia , Fatores de Risco , Disfunções Sexuais Fisiológicas/fisiopatologia , Estatística como Assunto
15.
Nano Lett ; 14(5): 2837-42, 2014 May 14.
Artigo em Inglês | MEDLINE | ID: mdl-24684262

RESUMO

In this Letter, we report gate-tunable X-ray photoelectron emission from back-gated graphene transistors. The back-gated transistor geometry allows us to study photoemission from graphene layer and the dielectric substrate at various gate voltages. Application of gate voltage electrostatically dopes graphene and shifts the binding energy of photoelectrons in various ways depending on the origin and the generation mechanism(s) of the emitted electrons. The gate-induced shift of the Fermi energy of graphene alters the binding energy of the C 1s electrons, whereas the electric field of the gate electrodes shift the binding energy of core electrons emitted from the gate dielectric underneath the graphene layer. The gradual change of the local potential through depths of the gate dielectric provides quantitative electrical information about buried interfaces. Our results suggest that gate-tunable photoemission spectra with chemically specific information linked with local electrical properties opens new routes to elucidating operation of devices based especially on layered materials.

16.
Int Braz J Urol ; 41(2): 279-87, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26005969

RESUMO

INTRODUCTION: Ureteral obstruction is a common pathology and caused kidney fibrosis and dysfunction at late period. In this present, we investigated the antifibrotic and antiinflammatory effects of montelukast which is cysteinyl leukotriene receptor antagonist, on kidney damage after unilateral ureteral obstruction(UUO) in rats. MATERIALS AND METHODS: 32 rats divided four groups. Group 1 was control, group 2 was sham, group 3 was rats with UUO and group 4 was rats with UUO which were given montelukast sodium (oral 10 mg/kg/day). After 14 days, rats were killed and their kidneys were taken and blood analysis was performed. Tubular necrosis, mononuclear cell infiltration and interstitial fibrosis scoring were determined histopathologically in a part of kidneys; nitric oxide(NO), malondialdehyde(MDA) and reduced glutathione(GSH) levels were determined in the other part of kidneys. Urea-creatinine levels were investigated at blood analysis. Statistical analyses were made by the Chi-square test and one-way analysis of variance (ANOVA). RESULTS: There was no difference significantly for urea-creatinine levels between groups. Pathologically, there was serious tubular necrosis and fibrosis in group 3 and there was significantly decreasing for tubular necrosis and fibrosis in group 4(p<0.005). Also, there was significantly increasing for NO and MDA levels; decreasing for GSH levels in group 3 compared the other groups(p<0.005). CONCLUSION: We can say that montelukast prevent kidney damage with antioxidant effect, independently of NO.


Assuntos
Acetatos/uso terapêutico , Cisteína/antagonistas & inibidores , Rim/efeitos dos fármacos , Antagonistas de Leucotrienos/uso terapêutico , Quinolinas/uso terapêutico , Insuficiência Renal/prevenção & controle , Obstrução Ureteral/complicações , Acetatos/farmacologia , Animais , Creatinina/sangue , Ciclopropanos , Fibrose/prevenção & controle , Glutationa/análise , Rim/patologia , Antagonistas de Leucotrienos/farmacologia , Leucotrienos , Peroxidação de Lipídeos/efeitos dos fármacos , Masculino , Malondialdeído/análise , Óxido Nítrico/análise , Estresse Oxidativo/efeitos dos fármacos , Substâncias Protetoras/uso terapêutico , Quinolinas/farmacologia , Ratos Wistar , Insuficiência Renal/tratamento farmacológico , Insuficiência Renal/patologia , Reprodutibilidade dos Testes , Sulfetos , Resultado do Tratamento , Ureia/sangue
17.
Arch Ital Urol Androl ; 87(1): 83-6, 2015 Mar 31.
Artigo em Inglês | MEDLINE | ID: mdl-25847904

RESUMO

OBJECTIVE: To evaluate the relationship among urolithiasis, metabolic syndrome (MetS) and serum testosterone (T) level in men. MATERIAL AND METHODS: 513 men older than 18 years were enrolled in this study: 313 of the subjects had a history of stones (group 1) and 200 had no history of stones (controls, group 2). Early morning T levels were recorded and anthropometric measurements were investigated to evaluate MetS. Analyses were completed using chi-square tests. RESULT: Serum T level was lower in stone forming patients than control subjects and 161 (%51.4) men in group 1 and 92 (%46) men in group 2 were diagnosed with metabolic syndrome. T level was found lower limit (< 285 ng/dl) in the MetS and urolithiasis group (p 0.002, OR 2.71). CONCLUSIONS: We found low testosterone levels in the patients with stone disease and prevalence of the MetS in men with urolithiasis was higher than in men without stone disease. Our findings show that levels of testosterone had no effect on stone formation, but the factors that cause stone formation can have an effect on the level of testosterone.


Assuntos
Síndrome Metabólica/sangue , Testosterona/sangue , Urolitíase/sangue , Adulto , Biomarcadores/sangue , Índice de Massa Corporal , Humanos , Masculino , Síndrome Metabólica/epidemiologia , Pessoa de Meia-Idade , Prevalência , Estudos Prospectivos , Fatores de Risco , Turquia/epidemiologia , Urolitíase/epidemiologia
18.
Arch Ital Urol Androl ; 87(2): 161-4, 2015 Jul 07.
Artigo em Inglês | MEDLINE | ID: mdl-26150037

RESUMO

PURPOSE: we aimed to compare the longterm outcome of surgical treatment of urethral stricture with the internal urethrotomy and plasmakinetic energy. MATERIAL AND METHODS: 60 patients, who have been operated due to urethral stricture were enrolled in our clinic. None of the patients had a medical history of urethral stricture. The urethral strictures were diagnosed by clinical history, uroflowmetry, ultrasonography and urethrography. The patients were divided two groups. Group 1 consisted of 30 patients treated with plasmakinetic urethrotomy and group 2 comprised 30 men treated with cold knife urethrotomy. RESULTS: There were no statistically significant differences between two groups in terms of patient age, maximum flow rate (Qmax) and quality of life score (Qol) value. A statistical difference between the two groups was observed when we compared the 3rd-month uroflowmetry results. Group 1 patients had a mean postoperative Qmax value of 16,1 ± 2,3 ml/s, whereas group 2 had a mean postoperative Qmax value of 15,1 ± 2,2 ml/s (p < 0.05). In the cold knife group, 3 of 11 (27,7%) recurrences appeared within the first 3 months, whereas in the plasmakinetic group zero recurrences appeared within the first 3 months in our study. The urethral stricture recurrence rate up to the 12 month period was statistically significant for group 1 (n = 7, 23%) compared with group 2 (n = 11, 37%) (p < 0.05). CONCLUSION: We believe that plasmakinetic surgery is better method than the cold knife technique for the treatment of urethral stricture.


Assuntos
Cistoscopia , Eletrocoagulação , Estreitamento Uretral/cirurgia , Idoso , Cistoscopia/métodos , Eletrocoagulação/métodos , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Resultado do Tratamento , Estreitamento Uretral/diagnóstico
19.
Nano Lett ; 13(12): 5851-7, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24215484

RESUMO

Optical modulators are commonly used in communication and information technology to control intensity, phase, or polarization of light. Electro-optic, electroabsorption, and acousto-optic modulators based on semiconductors and compound semiconductors have been used to control the intensity of light. Because of gate tunable optical properties, graphene introduces new potentials for optical modulators. The operation wavelength of graphene-based modulators, however, is limited to infrared wavelengths due to inefficient gating schemes. Here, we report a broadband optical modulator based on graphene supercapacitors formed by graphene electrodes and electrolyte medium. The transparent supercapacitor structure allows us to modulate optical transmission over a broad range of wavelengths from 450 nm to 2 µm under ambient conditions. We also provide various device geometries including multilayer graphene electrodes and reflection type device geometries that provide modulation of 35%. The graphene supercapacitor structure together with the high-modulation efficiency can enable various active devices ranging from plasmonics to optoelectronics.


Assuntos
Grafite/química , Óptica e Fotônica , Semicondutores , Luz
20.
Arch Ital Urol Androl ; 86(3): 215-6, 2014 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-25308588

RESUMO

OBJECTIVES: In recent years, it has been shown that there is association between metabolic syndrome and urinary stone disease. Stone disease and erectile dysfunction (ED) are considered as systemic diseases which are associated with hormonal and metabolic disorders. Therefore we investigated the relationship between ED and urinary tract calculi. MATERIAL AND METHODS: 98 male patients with urolithiasis and 59 randomly selected male patients without stone disease were included in the study. Serum testosterone (T) levels were measured and International Index of Erectile Function (IIEF)-15 questionnaire forms were used to assess ED. RESULTS: The prevalence of ED was found 29% (29 patients) in the urolithiasis group. Sixty-nine patients (71%) had no ED; 16 (16.3%) had mild, 5 (5.1%) had moderate and 8 (8.2%) had severe ED. None of the patients in the control group had severe or modarete ED, six patients (10.2%) had mild ED. Serum T levels were detected at the level of biochemical hypogonadism on 13 patients with stones (13.3%) and T levels were detected at the lower limit in 18 (18.3%) patients. CONCLUSION: In our study we have shown that ED and low T levels are significantly associated with urolithiasis. We propose that the patients with urolitiasis should be evaluated for ED and hypogonadism.

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