Detalhe da pesquisa
1.
A novel series of indazole-/indole-based glucagon receptor antagonists.
Bioorg Med Chem Lett
; 25(19): 4143-7, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26303893
2.
Discovery of N-aryl-2-acylindole human glucagon receptor antagonists.
Bioorg Med Chem Lett
; 21(23): 7124-30, 2011 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22030028
3.
Discovery of cyclic guanidines as potent, orally active, human glucagon receptor antagonists.
Bioorg Med Chem Lett
; 21(23): 7131-6, 2011 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22001094
4.
Discovery of novel, potent, selective, and orally active human glucagon receptor antagonists containing a pyrazole core.
Bioorg Med Chem Lett
; 21(1): 76-81, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21147532
5.
Discovery of potent, orally active benzimidazole glucagon receptor antagonists.
Bioorg Med Chem Lett
; 18(13): 3701-5, 2008 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18539028
6.
Cloning and expression of canine glucagon receptor and its use to evaluate glucagon receptor antagonists in vitro and in vivo.
Eur J Pharmacol
; 555(1): 8-16, 2007 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-17140563
7.
A novel glucagon receptor antagonist inhibits glucagon-mediated biological effects.
Diabetes
; 53(12): 3267-73, 2004 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-15561959
8.
Hepatic glucagon receptor binding and glucose-lowering in vivo by peptidyl and non-peptidyl glucagon receptor antagonists.
Eur J Pharmacol
; 501(1-3): 225-34, 2004 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-15464082
9.
Anti-diabetic efficacy and impact on amino acid metabolism of GRA1, a novel small-molecule glucagon receptor antagonist.
PLoS One
; 7(11): e49572, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23185367
10.
A genome-wide siRNA screen to identify modulators of insulin sensitivity and gluconeogenesis.
PLoS One
; 7(5): e36384, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22590537
11.
Discovery of a novel glucagon receptor antagonist N-[(4-{(1S)-1-[3-(3, 5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl)carbonyl]-ß-alanine (MK-0893) for the treatment of type II diabetes.
J Med Chem
; 55(13): 6137-48, 2012 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-22708876
12.
Discovery and investigation of a novel class of thiophene-derived antagonists of the human glucagon receptor.
Bioorg Med Chem Lett
; 15(5): 1401-5, 2005 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15713396
13.
Discovery of novel, potent, and orally active spiro-urea human glucagon receptor antagonists.
Bioorg Med Chem Lett
; 15(20): 4564-9, 2005 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16102966
14.
Regulation of insulin signal transduction pathway by a small-molecule insulin receptor activator.
Biochem J
; 367(Pt 1): 301-6, 2002 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12036431
15.
Detection of glucagon-dependent GTPgammaS binding in high-throughput format.
Anal Biochem
; 301(1): 156-9, 2002 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-11811981