RESUMO
Nonsteroidal anti-inflammatory drugs (NSAID) are used extensively in the general population. It's well known the adverse effects of NSAID over the upper gastrointestinal tract and small intestine. Enteric-coated and slow release preparations were created in order to prevent those effects. We describe a woman case who took diclofenac for many years and developed both ileal ulceration and diaphragm-like colonic structure. Lesions in lower gastrointestinal tract were infrequent but severe; the lesion were seen on colonoscopy but not on barium studies; the physiopathology of these lesions remains uncertain; and the most efficacy attitude is the suppression of diclofenac.
Assuntos
Anti-Inflamatórios não Esteroides/efeitos adversos , Colo/patologia , Diclofenaco/efeitos adversos , Doenças do Íleo/induzido quimicamente , Úlcera/induzido quimicamente , Doença Crônica , Colo/efeitos dos fármacos , Colo/ultraestrutura , Constrição Patológica/induzido quimicamente , Constrição Patológica/diagnóstico , Constrição Patológica/patologia , Feminino , Humanos , Doenças do Íleo/diagnóstico , Doenças do Íleo/patologia , Íleo/efeitos dos fármacos , Íleo/ultraestrutura , Mucosa Intestinal/efeitos dos fármacos , Mucosa Intestinal/ultraestrutura , Pessoa de Meia-Idade , Úlcera/diagnóstico , Úlcera/patologiaRESUMO
A case of systemic lupus erythematosus in a 3-year-old girl is presented. The diagnosis is based on the systemic involvement and repeated positivity for anti-DNA antibodies and L.E. phenomenon. A renal biopsy under optic and electron microscopy, disclosed diffuse glomerular cell proliferation and electron-dense deposits along the basal membrane. Increased basement membrane-like material is present between mesangial cells. Hematoxilinic bodies or virus-like inclusions were not found. Treatment with corticosteroids gave good results. A trial with antimalarial drugs had to be discontinued due to gastric intolerance and alopecia.
Assuntos
Glomerulonefrite , Lúpus Eritematoso Sistêmico , Membrana Basal/patologia , Pré-Escolar , Diagnóstico Diferencial , Feminino , Glomerulonefrite/patologia , Humanos , Glomérulos Renais/patologia , Lúpus Eritematoso Sistêmico/patologiaRESUMO
OBJECTIVE: To report on a rare case of Pacinian neurofibroma of the vulva. METHODS: A 27-year-old patient who presented with a vulvar tumor is described. Patient evaluation showed no other remarkable findings. RESULTS: The nodule was resected without difficulty. The histopathological analysis-demonstrated Pacinian neurofibroma with abundant concentric laminar structures. The immunohistochemical (CD34+), ultrastructural and histological analyses showed perineural cells. No signs of neurofibromatosis were found. CONCLUSIONS: Pacinian neurofibroma may present in the vulva and could probably arise from the so-called perineural fibroblasts.