Detalhe da pesquisa
1.
The orally bioavailable GSPT1/2 degrader SJ6986 exhibits in vivo efficacy in acute lymphoblastic leukemia.
Blood
; 142(7): 629-642, 2023 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37172201
2.
Capmatinib is an effective treatment for MET-fusion driven pediatric high-grade glioma and synergizes with radiotherapy.
Mol Cancer
; 23(1): 123, 2024 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38849845
3.
Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia.
Blood
; 138(23): 2313-2326, 2021 12 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34110416
4.
Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs.
Angew Chem Int Ed Engl
; 60(51): 26663-26670, 2021 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34614283
5.
Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints.
Bioorg Med Chem
; 28(1): 115194, 2020 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31786008
6.
Biased agonism: An emerging paradigm in GPCR drug discovery.
Bioorg Med Chem Lett
; 26(2): 241-250, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26707396
7.
A high-throughput quality control method for assessing the serial dilution performance of dose-response plates with acoustic ejection mass spectrometry.
SLAS Technol
; 29(1): 100115, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-37925158
8.
Sonic Hedgehog activates prostaglandin signaling to stabilize primary cilium length.
J Cell Biol
; 223(9)2024 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38856684
9.
Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma.
Cell Rep Med
; 5(3): 101468, 2024 Mar 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38508144
10.
Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines.
Nat Commun
; 15(1): 482, 2024 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38228616
11.
Development and Validation of a Liquid Chromatography-Tandem Mass Spectrometry Method for Sensitive Analysis of Residual Protein Tat Bh1-101 in Lentiviral Vectors for Gene Therapy.
Hum Gene Ther
; 34(21-22): 1162-1171, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37672543
12.
Design of Class I/IV Bromodomain-Targeting Degraders for Chromatin Remodeling Complexes.
ACS Chem Biol
; 18(6): 1278-1293, 2023 06 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-37260298
13.
Phenyl Dihydrouracil: An Alternative Cereblon Binder for PROTAC Design.
ACS Med Chem Lett
; 14(2): 141-145, 2023 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36793425
14.
Combination of Ribociclib with BET-Bromodomain and PI3K/mTOR Inhibitors for Medulloblastoma Treatment In Vitro and In Vivo.
Mol Cancer Ther
; 22(1): 37-51, 2023 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36318650
15.
Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential.
Eur J Med Chem
; 247: 115035, 2023 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36603507
16.
From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors.
Eur J Med Chem
; 251: 115246, 2023 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36898329
17.
Stromal-induced epithelial-mesenchymal transition induces targetable drug resistance in acute lymphoblastic leukemia.
Cell Rep
; 42(7): 112804, 2023 07 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37453060
18.
ATM inhibition enhances the efficacy of radiation across distinct molecular subgroups of pediatric high-grade glioma.
Neuro Oncol
; 25(10): 1828-1841, 2023 10 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36971093
19.
Recent Advances with KDM4 Inhibitors and Potential Applications.
J Med Chem
; 65(14): 9564-9579, 2022 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35838529
20.
Ca2+-mediated mitochondrial inner membrane permeabilization induces cell death independently of Bax and Bak.
Cell Death Differ
; 29(7): 1318-1334, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35726022