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1.
Pak J Pharm Sci ; 32(4(Supplementary)): 1767-1772, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31680071

RESUMO

A chemically preserved food has raised mental health issues. Abnormalities in liver and kidney functions have been reported from mentally imbalanced individuals. This study was focused on finding anxiety issues and biochemistry alterations in brain tumor patients and in controls. The levels of liver & kidney enzymes were compared in both groups through Mann-Whitney U test. Kendall's tau-b correlation was conducted to determine that is there any relationship between anxiety levels and biochemistry parameters in both groups. There was more occurrence of severe anxiety levels (58%) in brain tumor patients. There were more mood swings in CG (64%) as compared to BP (48%). Less sleeping pattern was found in CG (42%) as compared to BP (37%). More patients (58%) were having severe anxiety levels as compared to CG (52%). 73% patients were having low levels of alkaline phosphatase (AP). 52% individuals in CG were having low levels of AP. AP was found significantly associated with anxiety levels in brain tumor patients only. A nutrient deprived food from preservation can reduce levels of alkaline phosphatase. This can impact metabolism of necessary minerals for proper brain function. This epidemiological study reports a significant association between anxiety and reduced AP levels.


Assuntos
Antipsicóticos/efeitos adversos , Neoplasias Encefálicas/fisiopatologia , Aditivos Alimentares/efeitos adversos , Rim/efeitos dos fármacos , Fígado/efeitos dos fármacos , Água/efeitos adversos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Fosfatase Alcalina/metabolismo , Ansiedade/induzido quimicamente , Neoplasias Encefálicas/metabolismo , Estudos de Casos e Controles , Criança , Estudos Epidemiológicos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem
2.
Pak J Pharm Sci ; 32(6(Supplementary)): 2859-2864, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32024625

RESUMO

Frozen food chemicals contain neurotoxins which disturb electrolyte levels. Altered electrolyte levels can induce mental illnesses. This study was focused on finding the prevalence of depression, dementia, intake of antidepressants and electrolytic alterations in brain cancer (BC) patients and in control group (CG) who were taking frozen and canned food. The levels of electrolytes were compared in both groups through Mann-Whitney U test. The Odds Ratio (OR) and Relative Risks (RR) were calculated of having a specific occurrence or condition of brain cancer patients vs. controls. Majority (41.42%) patients were from the age group 33-57 years. There were 52% male and 47% female patients. There was more occurrence of dementia (41%) and depression (6%) in patients as compared to CG. 94% patients were found with dementia. 32% patients were having low levels of sodium and 43% were having low levels of potassium. High levels of potassium (26%) were found in CG. 76% patients and 73% controls were taking canned food in moderation. 69% patients and 50% controls were taking frozen food in moderation. The potassium levels (p value: 0.00001) and sodium levels (p value: 0.01468) were found at significant difference in brain cancer patients and control group. Statistically significantly higher odds of outcome (OR>1) and increased relative risks (RR) were reported in dementia, depression and intake of anti-depressants for BC vs. CG. This epidemiological study reports hyponatremia as a significantly different parameter between brain cancer patients and controls. Food's chemicals induce hyponatremia, which can disturb mental states to develop different neurological conditions.


Assuntos
Neoplasias Encefálicas/fisiopatologia , Demência/etiologia , Depressão/etiologia , Alimentos Congelados/efeitos adversos , Hiponatremia/induzido quimicamente , Adolescente , Adulto , Idoso , Antidepressivos/uso terapêutico , Neoplasias Encefálicas/metabolismo , Estudos de Casos e Controles , Criança , Demência/metabolismo , Depressão/tratamento farmacológico , Depressão/metabolismo , Feminino , Humanos , Hiponatremia/metabolismo , Masculino , Pessoa de Meia-Idade , Razão de Chances , Potássio/metabolismo , Prevalência , Risco , Sódio/metabolismo , Adulto Jovem
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