Detalhe da pesquisa
1.
An Exploratory Study Provides Insights into MMP9 and Aß Levels in the Vitreous and Blood across Different Ages and in a Subset of AMD Patients.
Int J Mol Sci
; 23(23)2022 Nov 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36498929
2.
Progress in developing rodent models of age-related macular degeneration (AMD).
Exp Eye Res
; 203: 108404, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33340497
3.
In vitro stem cell modelling demonstrates a proof-of-concept for excess functional mutant TIMP3 as the cause of Sorsby fundus dystrophy.
J Pathol
; 252(2): 138-150, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32666594
4.
An In-Vitro Cell Model of Intracellular Protein Aggregation Provides Insights into RPE Stress Associated with Retinopathy.
Int J Mol Sci
; 21(18)2020 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32932802
5.
3D-Reconstructed Retinal Pigment Epithelial Cells Provide Insights into the Anatomy of the Outer Retina.
Int J Mol Sci
; 21(21)2020 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33182490
6.
Sorsby fundus dystrophy - A review of pathology and disease mechanisms.
Exp Eye Res
; 165: 35-46, 2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28847738
7.
The Alzheimer's-related amyloid beta peptide is internalised by R28 neuroretinal cells and disrupts the microtubule associated protein 2 (MAP-2).
Exp Eye Res
; 153: 110-121, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27751744
8.
A laser-induced mouse model of progressive retinal degeneration with central sparing displays features of parafoveal geographic atrophy.
Sci Rep
; 13(1): 4194, 2023 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36918701
9.
A high-throughput 3D X-ray histology facility for biomedical research and preclinical applications.
Wellcome Open Res
; 8: 366, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37928208
10.
Human equivalent doses of L-DOPA rescues retinal morphology and visual function in a murine model of albinism.
Sci Rep
; 13(1): 17173, 2023 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37821525
11.
A High Fat "Western-style" Diet Induces AMD-Like Features in Wildtype Mice.
Mol Nutr Food Res
; 66(11): e2100823, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35306732
12.
Evidence that the Ser192Tyr/Arg402Gln in cis Tyrosinase gene haplotype is a disease-causing allele in oculocutaneous albinism type 1B (OCA1B).
NPJ Genom Med
; 7(1): 2, 2022 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35027574
13.
Oligomeric Aß1-42 Induces an AMD-Like Phenotype and Accumulates in Lysosomes to Impair RPE Function.
Cells
; 10(2)2021 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33671133
14.
Study of Intracellular Cargo Trafficking and Co-localization in the Phagosome and Autophagy-Lysosomal Pathways of Retinal Pigment Epithelium (RPE) Cells.
Methods Mol Biol
; 2150: 167-182, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-30969403
15.
The Diverse Roles of TIMP-3: Insights into Degenerative Diseases of the Senescent Retina and Brain.
Cells
; 9(1)2019 12 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31877820
16.
Oxidative Stress and Dysfunctional Intracellular Traffic Linked to an Unhealthy Diet Results in Impaired Cargo Transport in the Retinal Pigment Epithelium (RPE).
Mol Nutr Food Res
; 63(15): e1800951, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30835933
17.
A small gene sequencing panel realises a high diagnostic rate in patients with congenital nystagmus following basic phenotyping.
Sci Rep
; 9(1): 13229, 2019 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31519934
18.
Impaired lysosomes in the retinal pigment epithelium play a central role in the degeneration of the neuroretina.
Neural Regen Res
; 18(12): 2697-2698, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37449628
19.
The disparity between funding for eye research vs. the high cost of sight-loss in the UK.
Eye (Lond)
; 37(4): 584-586, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36167984
20.
Impaired Cargo Clearance in the Retinal Pigment Epithelium (RPE) Underlies Irreversible Blinding Diseases.
Cells
; 7(2)2018 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-29473871