Detalhe da pesquisa
1.
In Vitro and In Vivo Properties of CUO246, a Novel Bacterial DNA Gyrase/Topoisomerase IV Inhibitor.
Antimicrob Agents Chemother
; 66(12): e0092122, 2022 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36448795
2.
Development of a cyclosporin A derivative with excellent anti-hepatitis C virus potency.
Bioorg Med Chem
; 26(4): 957-969, 2018 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28919180
3.
Evaluation of JAK3 Biology in Autoimmune Disease Using a Highly Selective, Irreversible JAK3 Inhibitor.
J Pharmacol Exp Ther
; 361(2): 229-244, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28193636
4.
Potent benzoazepinone γ-secretase modulators with improved bioavailability.
Bioorg Med Chem Lett
; 25(17): 3495-500, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26142947
5.
Beyond Rule of Five and PROTACs in Modern Drug Discovery: Polarity Reducers, Chameleonicity, and the Evolving Physicochemical Landscape.
J Med Chem
; 67(7): 5683-5698, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38498697
6.
Targeting IRAK3 for Degradation to Enhance IL-12 Pro-inflammatory Cytokine Production.
ACS Chem Biol
; 17(6): 1315-1320, 2022 06 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35580266
7.
Piperazinyl pyrimidine derivatives as potent gamma-secretase modulators.
Bioorg Med Chem Lett
; 20(3): 1269-71, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20022243
8.
Purine derivatives as potent gamma-secretase modulators.
Bioorg Med Chem Lett
; 20(7): 2279-82, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20207146
9.
Structural basis for therapeutic inhibition of influenza A polymerase PB2 subunit.
Sci Rep
; 7(1): 9385, 2017 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28839261
10.
On the remarkable antitumor properties of fludelone: how we got there.
Angew Chem Int Ed Engl
; 44(19): 2838-50, 2005 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-15880547
11.
Samarium(II) iodide mediated radical/polar crossover reactions of cyclobutenes. An efficient approach to the BCD ring system of the penitrems.
Org Lett
; 5(4): 419-22, 2003 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-12583733
12.
On the introduction of a trifluoromethyl substituent in the epothilone setting: chemical issues related to ring forming olefin metathesis and earliest biological findings.
Org Lett
; 4(23): 4081-4, 2002 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-12423091
13.
Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition.
J Med Chem
; 57(20): 8503-16, 2014 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25310383
14.
Synthesis and conformational analysis of (E)-9,10-dehydroepothilone B: a suggestive link between the chemistry and biology of epothilones.
Angew Chem Int Ed Engl
; 42(22): 2518-21, 2003 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-12800175
15.
Design and total synthesis of a superior family of epothilone analogues, which eliminate xenograft tumors to a nonrelapsable state.
Angew Chem Int Ed Engl
; 42(39): 4762-7, 2003 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-14562342
16.
3-Aryl-4-hydroxyquinolin-2(1H)-one derivatives as type I fatty acid synthase inhibitors.
Bioorg Med Chem Lett
; 16(17): 4620-3, 2006 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16784844
17.
Quasiracemic synthesis: concepts and implementation with a fluorous tagging strategy to make both enantiomers of pyridovericin and mappicine.
J Am Chem Soc
; 124(20): 5774-81, 2002 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-12010052
18.
Radical and palladium-catalyzed cyclizations to cyclobutenes: an entry to the BCD ring system of penitrem D.
J Org Chem
; 69(11): 3719-25, 2004 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-15153001
19.
Total syntheses of [17]- and [18]dehydrodesoxyepothilones B via a concise ring-closing metathesis-based strategy: correlation of ring size with biological activity in the epothilone series.
J Org Chem
; 67(22): 7737-40, 2002 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12398497
20.
Application of ring-closing metathesis reactions in the synthesis of epothilones.
J Nat Prod
; 67(2): 139-43, 2004 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-14987048