RESUMO
The case histories of two Afro-Trinidadian brothers aged 8 and 11 years who developed end-stage renal disease (ESRD) are presented. Neither had had cause in the past to seek medical attention for any renal-related illness. At presentation both had anaemia, growth failure and other clinical and laboratory evidence of ESRD. Kidney histology in one child was consistent with familial juvenile nephronophthisis (NPH). This is common cause of ESRD in children in other countries but it has not been recognized previously in Trinidadian and other West Indian children, and should be considered as a possible aetiology in West Indian children presenting with renal failure.(AU)
Assuntos
Criança , Humanos , Masculino , Relatos de Casos , Insuficiência Renal Crônica/patologia , Rim em Esponja Medular/complicações , Rim em Esponja Medular/genética , Rim em Esponja Medular/patologia , Núcleo Familiar , Peritonite/etiologia , Trinidad e Tobago , Transtornos do Crescimento/etiologia , Insuficiência Renal Crônica/complicações , Insuficiência Renal Crônica/genéticaRESUMO
An extensive study of 3 isolated communities (1,700 persons) in Puerto Rico was presented (AU)