RESUMO
Specimens of the uterine tube epithelium (ampulla) were obtained from 20 healthy, prepubertal, ovariohysterectomized gilts. A 2 to 3% proportion of atypical cilia was observed. Of 6,600 transversely sectioned cilia, 122 (1.8%) had microtubular disorganization, whereas 444 of 48,080 totally examined cilia (0.9%) were compound, 104 (0.2%) were swollen, and 44 (0.09%) were intracytoplasmic.
Assuntos
Oviductos/ultraestrutura , Suínos , Fatores Etários , Animais , Cílios/ultraestrutura , Epitélio/ultraestrutura , Feminino , Microscopia EletrônicaRESUMO
The authors report the first case of abnormal length of respiratory cilia in a domestic animal (18 microns versus normal length about 5 microns). These cilia lie on the carpet of cilia of normal length. The width of some of these cilia is also abnormal, measuring 0.5-0.6 microns. Other cilia have hook-shaped tips that could be responsible for an effective beat. We suggest that the ineffective ciliary beat could also be due to the undulating movements of abnormally long cilia, and stress the need for further morphological and biochemical studies of respiratory cilia in pigs. Respiratory pathology is a very common finding in pigs and is responsible for remarkable economical losses.
Assuntos
Cílios/ultraestrutura , Transtornos da Motilidade Ciliar/veterinária , Doenças dos Suínos/patologia , Traqueia/ultraestrutura , Animais , Transtornos da Motilidade Ciliar/patologia , Modelos Animais de Doenças , Feminino , Microscopia Eletrônica de Varredura , Mucosa/ultraestrutura , SuínosRESUMO
The first description of a familial immotile cilia syndrome diagnosed through ovario-hysterectomy in six siblings of pigs has been performed. This report may indicate another possible cause of reproductive failure in domestic animals. In fact, the immotile cilia syndrome has not been considered from this point of view in veterinary medicine. This case emphasizes that a study about ciliary motility in the female reproductive tract in domestic animals is absolutely necessary to improve current knowledge about different causes of infertility. Up to date, it remains unknown what degree of ciliary motility is necessary for mammalian fertility in females.
Assuntos
Transtornos da Motilidade Ciliar/veterinária , Doenças dos Suínos/patologia , Animais , Bronquiectasia/patologia , Bronquiectasia/fisiopatologia , Bronquiectasia/veterinária , Bronquite/patologia , Bronquite/fisiopatologia , Bronquite/veterinária , Cílios/patologia , Cílios/fisiologia , Cílios/ultraestrutura , Transtornos da Motilidade Ciliar/patologia , Transtornos da Motilidade Ciliar/fisiopatologia , Dextrocardia/patologia , Dextrocardia/fisiopatologia , Dextrocardia/veterinária , Feminino , Histerectomia/veterinária , Infertilidade Feminina/patologia , Infertilidade Feminina/fisiopatologia , Infertilidade Feminina/veterinária , Microscopia Eletrônica , Ovariectomia/veterinária , Suínos , Doenças dos Suínos/fisiopatologiaRESUMO
This paper describes the ultrastructural alterations observed in the tracheal epithelium of six sibling swine suffering from porcine immotile cilia syndrome (PICS) compared with those in human immotile cilia syndrome (HICS). As in some human cases, the tracheal epithelium of these pigs was lined by cilia-lacking cells. A variety of dynein defects in other pigs suffering from PICS have been previously observed. The spectrum of defects affords evidence that the PICS is genetically heterogeneous. Available data suggests that there are many similarities between HICS and PICS. Therefore, it is proposed that PICS may prove to be a useful animal model for the human disease.