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1.
Anthropol Med ; 30(1): 31-47, 2023 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-36861381

RESUMO

The global rise of populism and concomitant polarizations across disenfranchised and marginalized groups has been magnified by so-called echo chambers, and a major public health crisis like the COVID-19 pandemic has only served to fuel these intergroup tensions. Media institutions disseminating information on ways to prevent the propagation of the virus have reactivated a specific discursive phenomenon previously observed in many epidemics: the construction of a defiled 'Other'. With anthropological lenses, discourse on defilement is an interesting path to understand the continuous emergence of pseudo-scientific forms of racism. In this paper, the authors focus on 'borderline racism', that is the use of an institutionally 'impartial' discourse to reaffirm the inferiority of another race. The authors employed inductive thematic analysis of 1200 social media comments reacting to articles and videos published by six media in three different countries (France, United States and India). Results delineate four major themes structuring defilement discourses: food (and the relationship to animals), religion, nationalism and gender. Media articles and videos portrayed Western and Eastern countries through contrasting images and elicited a range of reaction in readers and viewers. The discussion reflects on how borderline racism can be an appropriate concept to understand the appearance of hygienic othering of specific subgroups on social media. Theoretical implications and recommendations on a more culturally sensitive approach of media coverage of epidemics and pandemics are discussed.


Assuntos
COVID-19 , Racismo , Mídias Sociais , Estados Unidos , Humanos , Pandemias , Antropologia Médica , França
2.
Ann Surg Oncol ; 28(6): 3345-3353, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33005992

RESUMO

BACKGROUND: Flap reconstruction plays an important role in limb preservation after wide resection of extremity soft tissue sarcoma (ESTS), but can be associated with high rates of postoperative wound complications. Currently, no standardized system exists for the classification of these complications. This study aimed to develop a standardized classification system for wound complications after ESTS flap reconstruction. METHODS: Outcomes of ESTS flap reconstructions were analyzed in a retrospective cohort of 300 patients. All wound- and flap-related complications were identified and categorized. Based on these data, a scoring system was developed and validated with a prospective cohort of 100 patients who underwent ESTS flap reconstruction. RESULTS: A 10-point scoring system was developed based on the level of intervention required to treat each complication observed in the retrospective cohort. Raters applied the scoring system to the prospective patient cohort. Validation studies demonstrated excellent inter-rater and intra-rater reliability (weighted Cohen's kappa range, 0.82 [95% CI, 0.5-1.0] to 0.99 [95% CI, 0.98-1.0] and 0.95 [95% CI, 0.84-1.0] to 0.97 [95% CI, 0.92-1.0], respectively). The majority of the raters reported the score to be simple, objective, and reproducible (respective mean scores, 4.76 ± 0.43, 4.53 ± 0.62, and 4.56 ± 0.56 on 5-point Likert scales). CONCLUSION: The Toronto Sarcoma Flap Score (TSFS) is a simple and objective classification system with excellent inter- and intra-rater reliability. Universal adoption of the TSFS could standardize outcome reporting in future studies and aid in the establishment of clinical benchmarks to improve the quality of care in sarcoma reconstruction.


Assuntos
Procedimentos de Cirurgia Plástica , Sarcoma , Neoplasias de Tecidos Moles , Extremidades/cirurgia , Humanos , Salvamento de Membro , Estudos Prospectivos , Reprodutibilidade dos Testes , Estudos Retrospectivos , Sarcoma/cirurgia , Neoplasias de Tecidos Moles/cirurgia , Resultado do Tratamento
3.
J Zoo Wildl Med ; 52(2): 843-848, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-34130434

RESUMO

A 27-y-old female black-handed spider monkey (Ateles geoffroyi) was evaluated 13 d after an ovariohysterectomy because of abdominal distension, anorexia, and absent urination. The animal was diagnosed with a uroabdomen and urethral obstruction from computed tomographic findings and fluid creatinine levels. During exploratory laparotomy, a defect in the right ureter was confirmed as the source of the uroabdomen. Utilizing intraoperative fluoroscopy, a urethral obstruction with an irregular luminal filling defect was evident. A self-expanding nitinol urethral stent was placed, and a ureteral transposition was performed. Two months after the procedure, the animal developed dysuria, a urinary tract infection, recurrent bladder distension and a partial urethral obstruction. Treatment with prazosin 1 mg/kg PO q12h improved urination. Reobstruction of the urethra occurred 17 mo postsurgery, and the animal was euthanatized. On postmortem examination, the animal had ingrowth into the stent with proliferative granulation tissue, detrusor muscle degeneration, pelvic adhesions, cystitis, pyelonephritis, and hydronephrosis.


Assuntos
Ateles geoffroyi , Cistotomia/veterinária , Doenças dos Macacos/cirurgia , Stents/veterinária , Ureter/patologia , Animais , Animais de Zoológico , Cistotomia/métodos , Feminino , Ureter/cirurgia
4.
Ann Surg Oncol ; 27(9): 3466-3475, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32152777

RESUMO

BACKGROUND: Despite high success rates, flap failure remains an inherent risk in microvascular breast reconstruction. Identifying patients who are at high risk for flap failure would enable us to recommend alternative reconstructive techniques. However, as flap failure is a rare event, identification of risk factors is statistically challenging. Machine learning is a form of artificial intelligence that automates analytical model building. It has been proposed that machine learning can build superior prediction models when the outcome of interest is rare. METHODS: In this study we evaluate machine learning resampling and decision-tree classification models for the prediction of flap failure in a large retrospective cohort of microvascular breast reconstructions. RESULTS: A total of 1012 patients were included in the study. Twelve patients (1.1%) experienced flap failure. The ROSE informed oversampling technique and decision-tree classification resulted in a strong prediction model (AUC 0.95) with high sensitivity and specificity. In the testing cohort, the model maintained acceptable specificity and predictive power (AUC 0.67), but sensitivity was reduced. The model identified four high-risk patient groups. Obesity, comorbidities and smoking were found to contribute to flap loss. The flap failure rate in high-risk patients was 7.8% compared with 0.44% in the low-risk cohort (p = 0.001). CONCLUSIONS: This machine-learning risk prediction model suggests that flap failure may not be a random event. The algorithm indicates that flap failure is multifactorial and identifies a number of potential contributing factors that warrant further investigation.


Assuntos
Neoplasias da Mama/cirurgia , Sobrevivência de Enxerto , Aprendizado de Máquina , Mamoplastia , Retalhos Cirúrgicos/efeitos adversos , Retalhos Cirúrgicos/irrigação sanguínea , Adulto , Idoso , Inteligência Artificial , Regras de Decisão Clínica , Árvores de Decisões , Feminino , Humanos , Mamoplastia/efeitos adversos , Mamoplastia/métodos , Microcirculação , Pessoa de Meia-Idade , Prognóstico , Estudos Retrospectivos , Fatores de Risco
5.
Cult Med Psychiatry ; 44(1): 56-79, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31214902

RESUMO

This study aimed to analyze main groups accused on social media of causing or spreading the 2014-2016 Ebola epidemic in West Africa. In this analysis, blame is construed as a vehicle of meaning through which the lay public makes sense of an epidemic, and through which certain classes of people become "figures of blame". Data was collected from Twitter and Facebook using key word extraction, then categorized thematically. Our findings indicate an overall proximate blame tendency: blame was typically cast on "near-by" figures, namely national governments, and less so on "distant" figures, such as generalized figures of otherness ("Africans", global health authorities, global elites). Our results also suggest an evolution of online blame. In the early stage of the epidemic, blame directed at the affected populations was more prominent. However, during the peak of the outbreak, the increasingly perceived threat of inter-continental spread was accompanied by a progressively proximal blame tendency, directed at figures with whom the social media users had pre-existing biopolitical frustrations. Our study proposes that pro-active and on-going analysis of blame circulating in social media can usefully help to guide communications strategies, making them more responsive to public perceptions.


Assuntos
Comunicação , Epidemias , Conhecimentos, Atitudes e Prática em Saúde , Doença pelo Vírus Ebola , Mídias Sociais , Humanos , Pesquisa Qualitativa
6.
Can Vet J ; 61(3): 251-256, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-32165747

RESUMO

A 20-year-old Quarter horse gelding was referred for evaluation of an acute onset non-weight-bearing right forelimb lameness. Marked soft tissue swelling was apparent over the right scapula and shoulder region; no crepitus was palpable. A complete transverse fracture of the scapular neck was suspected based on ultrasonography and radiographs were obtained to confirm the presumptive diagnosis. A complete, oblique fracture of the right scapular neck with mild cranial and proximal displacement of the distal fragment was detected. Computed tomography of the upper right forelimb was performed post-mortem; lytic bony destruction of the scapular neck with a secondary pathologic fracture was observed. The lesion was considered most likely neoplastic. At necropsy a complete, comminuted fracture of the right scapula was confirmed, secondary to neoplastic invasion of the bone. A solitary, dorsally located, neoplastic mass was also observed within the parenchyma of the right caudal lung. Histopathologically, the lung and scapula lesions were similar, characteristic of a well-differentiated pulmonary carcinoma.


Fracture de l'omoplate secondaire à un carcinome pulmonaire métastasique chez un cheval : trouvailles cliniques, échographiques, radiographiques, par tomodensitométrie et pathologiques. Un cheval hongre Quarter horse âgé de 20 ans fut référé pour évaluation d'une boiterie de non-appui de la patte avant droite d'apparition aiguë. Une enflure marquée des tissus mous était apparente par-dessus l'omoplate droite et la région de l'épaule; aucun crépitement n'était palpable. Une fracture transverse complète du col de l'omoplate était suspectée sur la base de l'échographie et des radiographies furent obtenues pour confirmer le diagnostic présomptif. Un examen par tomodensitométrie de la portion supérieure du membre droit fut effectué post-mortem; une destruction osseuse lytique du col de l'omoplate avec une fracture pathologique secondaire fut observée. La lésion fut considérée comme fort probablement néoplasique. Lors de la nécropsie, une fracture comminutive complète de l'omoplate droite fut confirmée, secondaire à l'invasion néoplasique de l'os. Une masse néoplasique solitaire, localisée dorsalement fut également observée dans le parenchyme du poumon caudal droit. À l'examen histopathologique, les lésions du poumon et de l'omoplate étaient similaires, caractéristiques d'un carcinome pulmonaire bien différencié.(Traduit par Dr Serge Messier).


Assuntos
Fraturas Ósseas/veterinária , Doenças dos Cavalos , Neoplasias Pulmonares/veterinária , Animais , Cavalos , Masculino , Escápula , Tomografia Computadorizada por Raios X , Ultrassonografia
7.
J Surg Oncol ; 120(7): 1177-1183, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31562830

RESUMO

BACKGROUND: Immediate breast reconstruction has many advantages but is associated with higher complication rates than delayed reconstruction. Complications can delay the delivery of adjuvant cancer treatments. This study aimed to develop and validate a risk stratification model for the prediction of perioperative complications in immediate microvascular breast reconstruction. METHODS: The association between patient and treatment variables and perioperative complications was evaluated in a retrospective cohort of 351 women undergoing immediate breast reconstruction using free deep inferior epigastric artery perforator flaps. Multivariable logistic regression was used to determine the strength of association and weighted scores were assigned. Using cumulative risk scores, patients were stratified into low, intermediate, and high-risk groups. The model was then validated in a prospective cohort of 100 consecutive patients. RESULTS: Obesity, smoking, prior radiation, and comorbidities were important predictors and incorporated into the risk model. Complications occurred in 23.5% of low-risk (95% confidence interval [CI] = 17.7-29.2), 38.4% of intermediate-risk (95% CI = 29.2-47.5) and 53.9% of high-risk (95% CI = 33.3-74.4) patients. Validation confirmed a linear relationship between the risk stratification categories and complications in a model with good predictive power (c-statistic = 0.7, 95% CI = 0.6-0.8). CONCLUSION: A simple risk score, based on known preoperative variables, provides accurate risk stratification for patients considering immediate microvascular breast reconstruction.


Assuntos
Neoplasias da Mama/cirurgia , Mamoplastia/efeitos adversos , Modelos Estatísticos , Complicações Pós-Operatórias/etiologia , Medição de Risco/métodos , Neoplasias da Mama/irrigação sanguínea , Neoplasias da Mama/patologia , Feminino , Seguimentos , Humanos , Pessoa de Meia-Idade , Prognóstico , Estudos Prospectivos , Estudos Retrospectivos
8.
World J Surg ; 43(1): 96-106, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-30105637

RESUMO

Health literacy is the extent to which patients are able to understand and act upon health information. This concept is important for surgeons as their patients have to comprehend the nature, risks and benefits of surgical procedures, adhere to perioperative instructions, and make complex care decisions about interventions. Our review aimed to determine the prevalence of limited health literacy of the surgical patient population. A search of MEDLINE and EMBASE was performed from inception until January 14th 2017 for experimental and observational studies reporting surgical patients' health literacy measurement. Overall pooled proportion of surgical patients with limited health literacy was calculated using a random-effects model and methodologic quality was assessed. A total of 40 studies representing 18,895 surgical patients were included in our quantitative synthesis. Pooled estimate of limited health literacy was 31.7% (95%CI 24.7-39.2%, I2 99.0%). There was low risk of bias among the majority of the 51 studies included in the qualitative synthesis. Statistical heterogeneity could not be fully accounted for by methodologic quality or patient and surgical characteristics. However, some of the heterogeneity was accounted by measurement tool [combined proportions with the REALM and NVS of 35.6 (95%CI 31.5-39.9, I2 73.0%)]. A number of different health literacy measurement tools were used (19 overall). Our review demonstrates a high prevalence of limited health literacy among surgical patients with considerable heterogeneity. Our findings suggest the importance of recognizing and addressing surgical patients with limited health literacy and the need for standardization in measurement tools.


Assuntos
Conhecimentos, Atitudes e Prática em Saúde , Letramento em Saúde , Procedimentos Cirúrgicos Operatórios , Compreensão , Tomada de Decisões , Humanos , Cooperação do Paciente , Procedimentos Cirúrgicos Operatórios/efeitos adversos
9.
Ann Plast Surg ; 83(3): 258-263, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31021838

RESUMO

BACKGROUND: Anabolic-androgenic steroids (AAS) are widely implicated in gynecomastia development. Surgery is the definitive treatment for cases persisting after cessation of AAS use. Currently, the relevance of AAS use to the surgical approach of gynecomastia has not been well explored. This study aims to compare patient characteristics, surgical outcomes, and surgical management of gynecomastia correction in AAS users versus nonusers. METHODS: A retrospective cohort study was performed with patients who underwent bilateral gynecomastia reduction surgery between January 2005 and August 2015 by a single surgeon at an academic hospital. Demographic data, AAS usage details, operative documentation, and follow-up outcomes were reviewed. RESULTS: A total of 964 cases were reviewed. Eleven percent (n = 105) of the patients had a history of AAS use. Compared with non-AAS users, AAS users were older at time of gynecomastia onset (15 years vs 13 years, P < 0.001) and surgery (28 years vs 25 years, P < 0.001). The AAS users had higher body mass index (27.3 kg/m vs 25.7 kg/m, P < 0.001) and a greater proportion of patients self-identified as bodybuilders (40.0% vs 22.4%, P = 0.002). Although no difference was found in the excised bilateral mastectomy volume (92.1 cm vs 76.4 cm, P = 0.20), The AAS users had significantly less lipoaspirate fat volume (250 mL vs 300 mL, P = 0.005). No difference was found in total complication rates. However, AAS users had significantly more revision mastectomy surgeries (3.8% vs 1.1%; P = 0.02). CONCLUSIONS: The unique breast composition of AAS users necessitates a surgical approach with meticulous intraoperative hemostasis and careful glandular excision to minimize recurrence and achieve comparable low complication rates.


Assuntos
Ginecomastia/induzido quimicamente , Ginecomastia/cirurgia , Mastectomia , Congêneres da Testosterona/efeitos adversos , Adulto , Estudos de Coortes , Ginecomastia/epidemiologia , Humanos , Masculino , Prevalência , Estudos Retrospectivos , Resultado do Tratamento , Adulto Jovem
10.
Can J Surg ; 62(3): 1-3, 2019 03 22.
Artigo em Inglês | MEDLINE | ID: mdl-30900439

RESUMO

Summary: Decisional conflict represents a state of uncertainty regarding an action one must take. It is a concept inherent to shared decision-making and can help promote high-quality and patient-centred decisions in surgical care, leading to better outcomes. Specific elements may cause more uncertainty or decisional conflict for patients: lack of knowledge about risks and benefits, poorly defined personal values about the importance of those risks and benefits, perception of a lack of support, unpredictable outcomes, or the impression that an inadequate decision has been made. Decisional conflict can be measured in the surgical setting using the 16-item validated patient-reported Decisional Conflict Scale (DCS). Better understanding of the reasons behind high decisional conflict can help surgeons support high-quality decisions and lead to more satisfactory outcomes and less decisional regret.

11.
J Reconstr Microsurg ; 34(4): 277-292, 2018 May.
Artigo em Inglês | MEDLINE | ID: mdl-29536455

RESUMO

BACKGROUND: In 1986, Marko Godina published his seminal work regarding the timing of free-flap reconstruction for traumatic extremity defects. Early reconstruction, compared with delayed and late reconstruction resulted in significant decreases in free-flap failure rate, post-operative infections, hospitalization time, bone healing time, and number of additional anesthesias. The objective of this manuscript was to evaluate whether these principles continue to apply. METHODS: A meta-analysis was performed analyzing articles from Medline, Embase, and Pubmed. Four hundred and ninety-two articles were screened, and 134 articles were assessed for eligibility. Following full-text review, 43 articles were included in this study. RESULTS: The exact timing for free-flap reconstruction, free-flap failure rate, infection rate, and follow-up was defined in all 43 articles. Early free-flap reconstruction was found to have significantly lower rates of free-flap failure and infection in comparison to delayed reconstruction (p = 0.008; p = 0.0004). Compared with late reconstruction, early reconstruction was found to have significantly lower infection rates only (p = 0.01) with no difference in free-flap failures rates. Early reconstruction was found to lead to fewer additional procedures (p = 0.03). No statistical significance was found for bone healing time or hospitalization time. CONCLUSION: Early free-flap reconstruction performed within the first 72 hours resulted in a decreased rate of free-flap failures, infection, and additional procedures with no difference in other parameters. The largest majority of free flaps continue to be performed in a delayed time frame.


Assuntos
Retalhos de Tecido Biológico/irrigação sanguínea , Traumatismos da Perna/cirurgia , Microcirurgia , Procedimentos de Cirurgia Plástica , Sobrevivência de Enxerto , Humanos , Traumatismos da Perna/fisiopatologia , Tempo de Internação , Complicações Pós-Operatórias , Fatores de Tempo , Resultado do Tratamento
13.
Bioorg Med Chem Lett ; 23(19): 5267-9, 2013 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-23988352

RESUMO

Using Cu(I)-catalyzed azide-alkyne cycloaddition in a mixed classical organic phase and solid phase peptide synthesis approach, we synthesized four analogs of Leu-enkephalin to systematically replace amides by 1,4-disubstituted[1,2,3]triazoles. The peptidomimetics obtained were characterized by competitive binding, contractility assays and ERK1/2 phosphorylation. The present study reveals that the analog bearing a triazole between Phe and Leu retains some potency, more than all the others, suggesting that the hydrogen bond acceptor capacity of the last amide of Leu-enkephalin is essential for the biological activity of the peptide.


Assuntos
Amidas/química , Encefalina Leucina/química , Receptores Opioides delta/química , Triazóis/química , Ligação Competitiva , Encefalina Leucina/farmacologia , Ligação de Hidrogênio , Concentração Inibidora 50 , Estrutura Molecular , Peptidomiméticos , Receptores Opioides delta/efeitos dos fármacos
14.
CMAJ Open ; 11(6): E1148-E1154, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-38086558

RESUMO

BACKGROUND: First Nations children in Canada experience health inequities. We aimed to determine whether a self-report health app identified children's needs for support earlier in their illness than would typically occur. METHODS: Children (aged 8 to 18 yr) were recruited from a rural First Nation community. Children completed the Aaniish Naa Gegii: the Children's Health and Well-being Measure (ACHWM) and then met with a local mental health worker who determined their risk status. ACHWM Emotional Quadrant Scores (EQS) were compared between 3 groups of children: healthy peers (HP) who were not at risk, those with newly identified needs (NIN) who were at risk and not previously identified, and a typical treatment (TT) group who were at risk and already receiving support. RESULTS: We included 227 children (57.1% girls), and the mean age was 12.9 (standard deviation [SD] 2.9) years. The 134 children in the HP group had a mean EQS of 80.1 (SD 11.25), the 35 children in the NIN group had a mean EQS of 67.2 (SD 13.27) and the 58 children in the TT group had a mean EQS of 66.2 (SD 16.30). The HP group had significantly better EQS than the NIN and TT groups (p < 0.001). The EQS did not differ between the NIN and TT groups (p = 0.8). INTERPRETATION: The ACHWM screening process identified needs for support among 35 children, and the associated triage process connected them to local services; the similarity of EQS in the NIN and TT groups highlights the value of community screening to optimize access to services. Future research will examine the impact of this process over the subsequent year in these groups.

15.
Sci Immunol ; 8(85): eadg0033, 2023 07 28.
Artigo em Inglês | MEDLINE | ID: mdl-37506197

RESUMO

Type I interferons (IFN-I) are critical mediators of innate control of viral infections but also drive the recruitment of inflammatory cells to sites of infection, a key feature of severe coronavirus disease 2019. Here, IFN-I signaling was modulated in rhesus macaques (RMs) before and during acute SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection using a mutated IFN-α2 (IFN-modulator; IFNmod), which has previously been shown to reduce the binding and signaling of endogenous IFN-I. IFNmod treatment in uninfected RMs was observed to induce a modest up-regulation of only antiviral IFN-stimulated genes (ISGs); however, in SARS-CoV-2-infected RMs, IFNmod reduced both antiviral and inflammatory ISGs. IFNmod treatment resulted in a potent reduction in SARS-CoV-2 viral loads both in vitro in Calu-3 cells and in vivo in bronchoalveolar lavage (BAL), upper airways, lung, and hilar lymph nodes of RMs. Furthermore, in SARS-CoV-2-infected RMs, IFNmod treatment potently reduced inflammatory cytokines, chemokines, and CD163+ MRC1- inflammatory macrophages in BAL and expression of Siglec-1 on circulating monocytes. In the lung, IFNmod also reduced pathogenesis and attenuated pathways of inflammasome activation and stress response during acute SARS-CoV-2 infection. Using an intervention targeting both IFN-α and IFN-ß pathways, this study shows that, whereas early IFN-I restrains SARS-CoV-2 replication, uncontrolled IFN-I signaling critically contributes to SARS-CoV-2 inflammation and pathogenesis in the moderate disease model of RMs.


Assuntos
COVID-19 , Interferon Tipo I , Animais , Interferon Tipo I/farmacologia , SARS-CoV-2 , Macaca mulatta , Replicação Viral , Antivirais/farmacologia , Antivirais/uso terapêutico , Inflamação/tratamento farmacológico
16.
Oral Maxillofac Surg Clin North Am ; 34(3): 421-433, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-35871864

RESUMO

The resurgence of strip craniectomies began in the mid-1990s with advances in surgical technique and anesthesia coupled with the critical observation that earlier interventions benefitted from an easily molded skull. Jimenez and Barone's pioneering introduction of endoscopic approaches to strip craniectomies coupled with postoperative helmeting in newborns and young infants and Claes Lauritzen's introduction of spring-mediated cranioplasty began the era of minimally invasive approaches in the surgical correction of craniosynostosis. This article provides technical descriptions of these treatment modalities, a comparative literature review, and our institutional algorithms for the correction of sagittal craniosynostosis and unilambdoid craniosynostosis.


Assuntos
Craniossinostoses , Craniossinostoses/cirurgia , Craniotomia/métodos , Humanos , Lactente , Recém-Nascido , Crânio/cirurgia , Resultado do Tratamento
17.
Wounds ; 34(8): E51-E56, 2022 08.
Artigo em Inglês | MEDLINE | ID: mdl-36108242

RESUMO

INTRODUCTION: Surgical management of NSTIs can result in complex wounds, and closure of these wounds is often difficult or complicated. Although surgical factors influencing mortality and LOS have been well described, little is known about patient, wound, and surgical factors associated with time to closure. OBJECTIVE: The purpose of this study is to identify patient, wound, and surgical factors that may influence time to closure of NSTIs. MATERIALS AND METHODS: The records of patients who presented to a tertiary care center over an 11-year period (2007-2017) with an NSTI requiring surgical closure were retrospectively reviewed. RESULTS: Forty-seven patients met the inclusion criteria. The average time to closure was 31.1 days, with an average of 4.8 procedures. Most patients were middle aged (mean, 50.3 years; range, 20-81 years), immunocompetent, and nondiabetic upon admission. Closure was achieved mainly with autograft. The percent TBSA was described in 19 cases (40%). There was no association between substance use (alcohol, smoking, or other), anticoagulant medication use, or medical comorbidities and time to closure. On multivariable analysis, flap closure (P =.02) and increased number of surgical procedures (P =.003)-the latter reflecting the need for an increased number of debridements-were associated with increased time to closure. CONCLUSIONS: The data in this study suggest that use of local flaps for wound closure and increased number of surgical procedures (particularly debridements) may be predictors of time to closure in patients with an NSTI.


Assuntos
Infecção dos Ferimentos , Anticoagulantes , Desbridamento/métodos , Humanos , Pessoa de Meia-Idade , Estudos Retrospectivos , Técnicas de Fechamento de Ferimentos , Infecção dos Ferimentos/cirurgia
18.
Hand (N Y) ; : 15589447221120840, 2022 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-36050926

RESUMO

BACKGROUND: This study aimed to assess the responsiveness of the Trapeziometacarpal Arthrosis Symptoms and Disability (TASD) questionnaire after corticosteroid injections and operative management for trapeziometacarpal osteoarthritis (TMC-OA). METHODS: This longitudinal cohort study included patients with TMC-OA who underwent treatment (corticosteroid injection or surgery). Measurements occurred at baseline and follow-up time points: 6 weeks, 3 months, 6 months, and 1 year. Patient measures were collected electronically using a data repository platform. The TASD is a validated psychometric patient-administered scale. We examined responsiveness by correlating the TASD scores with another known effective indicator of change (shortened Disabilities of the Arm, Shoulder, and Hand [QuickDASH]). Repeated score measurements over time were analyzed using analysis of variance, and correlations between questionnaires were reported with repeated measures correlation and Pearson correlation coefficients. RESULTS: The nonsurgical cohort undergoing corticosteroid injections included 31 (66%) women and 16 (34%) men, and the surgical cohort included 29 (71%) women and 12 (29%) men. Both the QuickDASH and the TASD captured a statistically significant improvement in symptom burden postoperatively (P < .0001 for both questionnaires), whereas no statistical significance was noted after corticosteroid injections (P = .45 and P = .34, respectively). There was a strong correlation between QuickDASH and TASD questionnaires (r = 0.87, P < .0001). CONCLUSIONS: The TASD is a promising TMC-OA-specific questionnaire to capture responsiveness following treatment, particularly following surgery. The responsiveness of TASD was demonstrated in the TMC-OA cohort. Further research is needed to define a minimal clinically important difference.

19.
bioRxiv ; 2022 Oct 24.
Artigo em Inglês | MEDLINE | ID: mdl-36324810

RESUMO

Type-I interferons (IFN-I) are critical mediators of innate control of viral infections, but also drive recruitment of inflammatory cells to sites of infection, a key feature of severe COVID-19. Here, and for the first time, IFN-I signaling was modulated in rhesus macaques (RMs) prior to and during acute SARS-CoV-2 infection using a mutated IFNα2 (IFN-modulator; IFNmod), which has previously been shown to reduce the binding and signaling of endogenous IFN-I. In SARS-CoV-2-infected RMs, IFNmod reduced both antiviral and inflammatory ISGs. Notably, IFNmod treatment resulted in a potent reduction in (i) SARS-CoV-2 viral load in Bronchoalveolar lavage (BAL), upper airways, lung, and hilar lymph nodes; (ii) inflammatory cytokines, chemokines, and CD163+MRC1-inflammatory macrophages in BAL; and (iii) expression of Siglec-1, which enhances SARS-CoV-2 infection and predicts disease severity, on circulating monocytes. In the lung, IFNmod also reduced pathogenesis and attenuated pathways of inflammasome activation and stress response during acute SARS-CoV-2 infection. This study, using an intervention targeting both IFN-α and IFN-ß pathways, shows that excessive inflammation driven by type 1 IFN critically contributes to SARS-CoV-2 pathogenesis in RMs, and demonstrates the potential of IFNmod to limit viral replication, SARS-CoV-2 induced inflammation, and COVID-19 severity.

20.
JSLS ; 25(3)2021.
Artigo em Inglês | MEDLINE | ID: mdl-34671175

RESUMO

STUDY OBJECTIVES: The primary objective is to determine the rate of morbid events (urinary tract infection, hematuria, urinary retention, false positive, incidental finding) associated with routine cystoscopies performed intraoperatively during total laparoscopic hysterectomies (TLH). The secondary objectives are 1) to determine the rate of urinary complications during TLHs in our centers and 2) to determine the detection rate of urinary complications using cystoscopy during TLHs. METHOD: Descriptive retrospective multicenter study. The study took place in Obstetrics & Gynecology departments of 2 university centers in Montreal. Patients underwent a routine cystoscopy during their TLH for a benign reason in our centers. Five hundred thirty-one charts from January 1, 2012 to January 31, 2018 were reviewed. RESULTS: The morbidity rate of routine cystoscopies during TLHs is 4.19% (22/524 cases) in our centers. Our urinary complication rate is 2.45% (13/531 cases). Of these 13 complications, 4 were detected by cystoscopy. CONCLUSION: The usefulness of routine cystoscopies performed intraoperatively during TLHs is questionable due to the number of morbid events and the low rate of urinary trauma in our centers. However, it is hard to establish a direct causality link between certain morbid events and cystoscopy. More studies should be conducted on this subject.


Assuntos
Cistoscopia , Laparoscopia , Feminino , Humanos , Histerectomia , Morbidade , Estudos Retrospectivos , Bexiga Urinária/diagnóstico por imagem , Bexiga Urinária/cirurgia
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