Detalhe da pesquisa
1.
A parallel integrated learning technique of improved particle swarm optimization and BP neural network and its application.
Sci Rep
; 12(1): 19325, 2022 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36369241
2.
Deep Learning Based on Hierarchical Self-Attention for Finance Distress Prediction Incorporating Text.
Comput Intell Neurosci
; 2021: 1165296, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34925482
3.
Towards the second generation of Boceprevir: Dithianes as an alternative P2 substituent for 2,2-dimethyl cycloproyl proline in HCV NS3 protease inhibitors.
Bioorg Med Chem Lett
; 20(5): 1689-92, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20149655
4.
Discovery of SCH446211 (SCH6): a new ketoamide inhibitor of the HCV NS3 serine protease and HCV subgenomic RNA replication.
J Med Chem
; 49(9): 2750-7, 2006 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-16640336
5.
Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor: a potential therapeutic agent for the treatment of hepatitis C infection.
J Med Chem
; 49(20): 6074-86, 2006 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-17004721
6.
Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor.
ACS Med Chem Lett
; 1(2): 64-9, 2010 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900178
7.
Toward the back-up of boceprevir (SCH 503034): discovery of new extended P4-capped ketoamide inhibitors of hepatitis C virus NS3 serine protease with improved potency and pharmacokinetic profiles.
J Med Chem
; 52(12): 3679-88, 2009 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-19456105
8.
Depeptidization efforts on P3-P2' alpha-ketoamide inhibitors of HCV NS3-4A serine protease: effect on HCV replicon activity.
Bioorg Med Chem Lett
; 16(6): 1621-7, 2006 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16387495