Detalhe da pesquisa
1.
Soluble guanylate cyclase stimulators for the treatment of hypertension: Discovery of MK-2947.
Bioorg Med Chem Lett
; 30(21): 127574, 2020 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32980512
2.
Assessing the Utility of In Vitro Screening Tools for Predicting Bio-Performance of Oral Peptide Delivery.
Pharm Res
; 36(10): 151, 2019 Aug 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31451949
3.
Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension.
Bioorg Med Chem Lett
; 27(11): 2384-2388, 2017 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28416132
4.
Investigation of piperazine benzamides as human ß3 adrenergic receptor agonists for the treatment of overactive bladder.
Bioorg Med Chem Lett
; 27(4): 1094-1098, 2017 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28089699
5.
Discovery of phenyl acetamides as potent and selective GPR119 agonists.
Bioorg Med Chem Lett
; 27(5): 1124-1128, 2017 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28185720
6.
Development of a Convenient In Vitro Gel Diffusion Model for Predicting the In Vivo Performance of Subcutaneous Parenteral Formulations of Large and Small Molecules.
AAPS PharmSciTech
; 18(6): 2203-2213, 2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-28070846
7.
Evaluation of CETP activity in vivo under non-steady-state conditions: influence of anacetrapib on HDL-TG flux.
J Lipid Res
; 57(3): 398-409, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26658238
8.
Discovery of benzamides as potent human ß3 adrenergic receptor agonists.
Bioorg Med Chem Lett
; 26(1): 55-9, 2016 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26590100
9.
Evaluation of cynomolgus monkeys for the identification of endogenous biomarkers for hepatic transporter inhibition and as a translatable model to predict pharmacokinetic interactions with statins in humans.
Drug Metab Dispos
; 43(6): 851-63, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25813937
10.
A novel series of indazole-/indole-based glucagon receptor antagonists.
Bioorg Med Chem Lett
; 25(19): 4143-7, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26303893
11.
Modulating Drug Release and Enhancing the Oral Bioavailability of Torcetrapib with Solid Lipid Dispersion Formulations.
AAPS PharmSciTech
; 16(5): 1091-100, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25690735
12.
Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes.
Proc Natl Acad Sci U S A
; 108(13): 5378-83, 2011 Mar 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-21389266
13.
Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2- (2,5-difluorophenyl)-5-(4,6-dihydropyrrolo [3,4-c]pyrazol-5-(1H)-yl)tetrahydro-2H-pyran-3-amine (23) [corrected].
Bioorg Med Chem Lett
; 23(19): 5361-6, 2013 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23972441
14.
Ten-Year Follow-up of 9-Valent Human Papillomavirus Vaccine: Immunogenicity, Effectiveness, and Safety.
Pediatrics
; 152(4)2023 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37667847
15.
Prediction of frozen virus stability based on degradation mechanisms, real-time data and modeling.
Bioanalysis
; 14(17): 1177-1190, 2022 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-36278321
16.
3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists.
Bioorg Med Chem Lett
; 21(11): 3390-4, 2011 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21514824
17.
Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective human ß3 adrenergic receptor agonists.
Bioorg Med Chem Lett
; 21(6): 1865-70, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21353541
18.
Discovery of N-aryl-2-acylindole human glucagon receptor antagonists.
Bioorg Med Chem Lett
; 21(23): 7124-30, 2011 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22030028
19.
Discovery of cyclic guanidines as potent, orally active, human glucagon receptor antagonists.
Bioorg Med Chem Lett
; 21(23): 7131-6, 2011 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22001094
20.
Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity.
Nat Med
; 8(2): 179-83, 2002 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-11821903