Detalhe da pesquisa
1.
Liposome Click Membrane Permeability Assay for Identifying Permeable Peptides.
Pharm Res
; 38(5): 843-850, 2021 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-33723794
2.
Assessing the Utility of In Vitro Screening Tools for Predicting Bio-Performance of Oral Peptide Delivery.
Pharm Res
; 36(10): 151, 2019 Aug 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31451949
3.
Rigorous Computational and Experimental Investigations on MDM2/MDMX-Targeted Linear and Macrocyclic Peptides.
Molecules
; 24(24)2019 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31847417
4.
Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties.
Molecules
; 24(12)2019 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31226791
5.
Macrocyclic α helical peptide therapeutic modality: A perspective of learnings and challenges.
Bioorg Med Chem
; 26(10): 2807-2815, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29598901
6.
Correction to: Liposome Click Membrane Permeability Assay for Identifying Permeable Peptides.
Pharm Res
; 38(4): 735-736, 2021 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-33821425
7.
Stapled α-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy.
Proc Natl Acad Sci U S A
; 110(36): E3445-54, 2013 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-23946421
8.
The novel peptide LCGM-10 attenuates metabotropic glutamate receptor 5 activity and demonstrates behavioral effects in animal models.
Front Behav Neurosci
; 18: 1333258, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38385004
9.
Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists.
Nat Commun
; 15(1): 489, 2024 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38216578
10.
Aqueous remote loading of setmelanotide in poly(lactic-co-glycolic acid) microspheres for long-term obesity treatment.
J Control Release
; 364: 589-600, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37678438
11.
Inhibition of the melanocortin-3 receptor (MC3R) causes generalized sensitization to anorectic agents.
bioRxiv
; 2023 Dec 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38106197
12.
Discovery of Sulanemadlin (ALRN-6924), the First Cell-Permeating, Stabilized α-Helical Peptide in Clinical Development.
J Med Chem
; 66(14): 9401-9417, 2023 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37439511
13.
Demonstration of a Common DPhe7 to DNal(2')7 Peptide Ligand Antagonist Switch for Melanocortin-3 and Melanocortin-4 Receptors Identifies the Systematic Mischaracterization of the Pharmacological Properties of Melanocortin Peptides.
J Med Chem
; 65(8): 5990-6000, 2022 04 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35404053
14.
Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR-ABL including the T315I gatekeeper mutant.
Bioorg Med Chem Lett
; 21(12): 3743-8, 2011 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21561767
15.
Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling.
Chem Sci
; 12(48): 15975-15987, 2021 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35024121
16.
NanoClick: A High Throughput, Target-Agnostic Peptide Cell Permeability Assay.
ACS Chem Biol
; 16(2): 293-309, 2021 02 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33539064
17.
Targeting anti-cancer agents to bone using bisphosphonates.
Bone
; 138: 115492, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32585321
18.
De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits.
ACS Med Chem Lett
; 11(10): 1993-2001, 2020 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33062184
19.
Macrocyclization of an all-d linear α-helical peptide imparts cellular permeability.
Chem Sci
; 11(21): 5577-5591, 2020 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32874502
20.
Photoredox Ni-catalyzed peptide C(sp2)-O cross-coupling: from intermolecular reactions to side chain-to-tail macrocyclization.
Chem Sci
; 10(19): 5073-5078, 2019 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31183058