Transient bold activity locked to perceptual reversals of auditory streaming in human auditory cortex and inferior colliculus.

Our auditory system separates and tracks temporally interleaved sound sources by organizing them into distinct auditory streams. This streaming phenomenon is partly determined by physical stimulus properties but additionally depends on the internal state of the listener. As a consequence, streaming perception is often bistable and reversals between one- and two-stream percepts may occur spontaneously or be induced by a change of the stimulus. Here, we used functional MRI to investigate perceptual reversals in streaming based on interaural time differences (ITD) that produce a lateralized stimulus perception. Listeners were continuously presented with two interleaved streams, which slowly moved apart and together again. This paradigm produced longer intervals between reversals than stationary bistable stimuli but preserved temporal independence between perceptual reversals and physical stimulus transitions. Results showed prominent transient activity synchronized with the perceptual reversals in and around the auditory cortex. Sustained activity in the auditory cortex was observed during intervals where the ΔITD could potentially produce streaming, similar to previous studies. A localizer-based analysis additionally revealed transient activity time locked to perceptual reversals in the inferior colliculus. These data suggest that neural activity associated with streaming reversals is not limited to the thalamo-cortical system but involves early binaural processing in the auditory midbrain, already.

Activity associated with stream segregation in human auditory cortex is similar for spatial and pitch cues.

Streaming is a perceptual mechanism by which the brain segregates information from multiple sound sources in our environment and assigns them to distinct auditory streams. Examples for streaming cues are differences in frequency spectrum, pitch, or space, and potential neural correlates for streaming based on spectral and pitch cues have been identified in the auditory cortex. Here, magnetoencephalography (MEG) and functional magnetic resonance imaging (fMRI) were used to evaluate if response enhancement in auditory cortex associated with streaming represents a general pattern that is independent of the stimulus cue. Interaural time differences (ITDs) were used as a spatial streaming cue and were compared with streaming based on fundamental frequency (f(0)) differences. The MEG results showed enhancement of the P(1)m after 60-90 ms that was similar during streaming based on ITD and pitch. Sustained fMRI activity was enhanced at identical sites in Heschl's gyrus and planum temporale for both cues; no topographical specificity for space or pitch was found for the streaming-associated enhancement. These results support the hypothesis of an early convergence of the neural representation for auditory streams that is independent of the acoustic cue that the streaming is based on.

Functional dissociation of transient and sustained fMRI BOLD components in human auditory cortex revealed with a streaming paradigm based on interaural time differences.

A number of physiological studies suggest that feature-selective adaptation is relevant to the pre-processing for auditory streaming, the perceptual separation of overlapping sound sources. Most of these studies are focused on spectral differences between streams, which are considered most important for streaming. However, spatial cues also support streaming, alone or in combination with spectral cues, but physiological studies of spatial cues for streaming remain scarce. Here, we investigate whether the tuning of selective adaptation for interaural time differences (ITD) coincides with the range where streaming perception is observed. FMRI activation that has been shown to adapt depending on the repetition rate was studied with a streaming paradigm where two tones were differently lateralized by ITD. Listeners were presented with five different ΔITD conditions (62.5, 125, 187.5, 343.75, or 687.5 µs) out of an active baseline with no ΔITD during fMRI. The results showed reduced adaptation for conditions with ΔITD ≥ 125 µs, reflected by enhanced sustained BOLD activity. The percentage of streaming perception for these stimuli increased from approximately 20% for ΔITD = 62.5 µs to > 60% for ΔITD = 125 µs. No further sustained BOLD enhancement was observed when the ΔITD was increased beyond ΔITD = 125 µs, whereas the streaming probability continued to increase up to 90% for ΔITD = 687.5 µs. Conversely, the transient BOLD response, at the transition from baseline to ΔITD blocks, increased most prominently as ΔITD was increased from 187.5 to 343.75 µs. These results demonstrate a clear dissociation of transient and sustained components of the BOLD activity in auditory cortex.