Detalhe da pesquisa
1.
Enzymatic transition states, transition-state analogs, dynamics, thermodynamics, and lifetimes.
Annu Rev Biochem
; 80: 703-32, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21675920
2.
Combined inhibition of MTAP and MAT2a mimics synthetic lethality in tumor models via PRMT5 inhibition.
J Biol Chem
; 300(1): 105492, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38000655
3.
Inverse heavy enzyme isotope effects in methylthioadenosine nucleosidases.
Proc Natl Acad Sci U S A
; 118(40)2021 10 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34580228
4.
Decreased Transition-State Analogue Affinity in Isotopically Heavy MTAN with Increased Catalysis.
Biochemistry
; 62(20): 2928-2933, 2023 10 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37788145
5.
Residence Times for Femtomolar and Picomolar Inhibitors of MTANs.
Biochemistry
; 62(11): 1776-1785, 2023 06 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37204861
6.
Phosphate Binding in PNP Alters Transition-State Analogue Affinity and Subunit Cooperativity.
Biochemistry
; 62(21): 3116-3125, 2023 11 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37812583
7.
Cell-Effective Transition-State Analogue of Phenylethanolamine N-Methyltransferase.
Biochemistry
; 62(15): 2257-2268, 2023 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37467463
8.
An enzyme-coupled microplate assay for activity and inhibition of hmdUMP hydrolysis by DNPH1.
Anal Biochem
; 672: 115171, 2023 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37142196
9.
Kinetic Characterization and Inhibition of Trypanosoma cruzi Hypoxanthine-Guanine Phosphoribosyltransferases.
Biochemistry
; 61(19): 2088-2105, 2022 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36193631
10.
A resistant mutant of Plasmodium falciparum purine nucleoside phosphorylase uses wild-type neighbors to maintain parasite survival.
J Biol Chem
; 296: 100342, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33524395
11.
The design of protozoan phosphoribosyltransferase inhibitors containing non-charged phosphate mimic residues.
Bioorg Med Chem
; 74: 117038, 2022 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36209571
12.
Protein Mass-Modulated Effects in Alkaline Phosphatase.
Biochemistry
; 60(2): 118-124, 2021 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33410323
13.
Mechanism and Inhibition of Human Methionine Adenosyltransferase 2A.
Biochemistry
; 60(10): 791-801, 2021 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33656855
14.
Aminofutalosine Deaminase in the Menaquinone Pathway of Helicobacter pylori.
Biochemistry
; 60(24): 1933-1946, 2021 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34077175
15.
Mechanism of Triphosphate Hydrolysis by Human MAT2A at 1.07 Å Resolution.
J Am Chem Soc
; 143(43): 18325-18330, 2021 11 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34668717
16.
Inverse enzyme isotope effects in human purine nucleoside phosphorylase with heavy asparagine labels.
Proc Natl Acad Sci U S A
; 115(27): E6209-E6216, 2018 07 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29915028
17.
Genetic resistance to purine nucleoside phosphorylase inhibition in Plasmodium falciparum.
Proc Natl Acad Sci U S A
; 115(9): 2114-2119, 2018 02 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-29440412
18.
Transition State Analogues Enhanced by Fragment-Based Structural Analysis: Bacterial Methylthioadenosine Nucleosidases.
Biochemistry
; 59(7): 831-835, 2020 02 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32022543
19.
Transition-State Analogues of Phenylethanolamine N-Methyltransferase.
J Am Chem Soc
; 142(33): 14222-14233, 2020 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32702980
20.
Enzymatic Transition States and Drug Design.
Chem Rev
; 118(22): 11194-11258, 2018 11 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30335982