RESUMO
The effect of large doses of dexamethasone (80 mg) on the cerebrospinal fluid pressure (CSFP) was investigated with continuous lumbar CSFP measurement over 24 h in 10 patients with supratentorial cerebral tumors and clinical signs of elevated intracranial pressure. There was a further slight rise in CSFP with an unchanged pressure pattern in the course of observation of the untreated control group. A marked lowering of CSFP was observed within 6 h after initial intravenous administration of dexamethasone to seven of the treated patients. In four of the treated patients an unequivocal and in five only a moderate CSFP lowering was measured at the end of the registration. One patient had a slight rise in pressure. The plateau waves of all the patients treated decreased in height, frequency and duration within the first hours, while fluctuations in pressure level and CSFP amplitude were reduced.
Assuntos
Neoplasias Encefálicas/tratamento farmacológico , Líquido Cefalorraquidiano/fisiologia , Dexametasona/uso terapêutico , Idoso , Astrocitoma/tratamento farmacológico , Edema Encefálico/tratamento farmacológico , Feminino , Glioblastoma/tratamento farmacológico , Humanos , Pressão Intracraniana , Masculino , Pessoa de Meia-Idade , Metástase Neoplásica , Oligodendroglioma/tratamento farmacológico , PressãoAssuntos
Edema Encefálico/tratamento farmacológico , Furosemida/farmacologia , Pressão Intracraniana/efeitos dos fármacos , Metilprednisolona/farmacologia , Espironolactona/farmacologia , Edema Encefálico/líquido cefalorraquidiano , Furosemida/uso terapêutico , Humanos , Metilprednisolona/uso terapêutico , Espironolactona/uso terapêuticoRESUMO
The effect of a new, powerful diuretic on biochemical parameters, urine output, central venous pressure, blood pressure, and cerebrospinal fluid pressure in patients with supratentorial intracerebral tumors who showed signs and symptoms of increased intracranial pressure was tested. When compared to an untreated control group and to the steady-state data of each patient, CSF pressure was significantly reduced using a dose of 240 mg of the diuretic. The 120 mg dosage did not produce significant results. Normalization of increased cerebrospinal fluid pressure was not completely obtained using either dose. Used alone, this substance is not suitable for treatment of increased intracranial pressure due to brain edema in patients with intra-cerebral tumors. It might, however, be useful in combination with other medications.