Detalhe da pesquisa
1.
Discovery and optimization of 2-pyridinone aminal integrase strand transfer inhibitors for the treatment of HIV.
Bioorg Med Chem Lett
; 27(9): 2038-2046, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28285916
2.
Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia.
Bioorg Med Chem Lett
; 26(1): 126-32, 2016 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26602277
3.
Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.
Bioorg Med Chem Lett
; 24(20): 4884-90, 2014 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25248679
4.
Shaping suvorexant: application of experimental and theoretical methods for driving synthetic designs.
J Comput Aided Mol Des
; 28(1): 5-12, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24488306
5.
Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic.
J Med Chem
; 67(5): 3935-3958, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38365209
6.
Discovery of tetrahydropyridopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia.
Bioorg Med Chem Lett
; 22(18): 5903-8, 2012 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22892116
7.
C-O cross-coupling of activated aryl and heteroaryl halides with aliphatic alcohols.
Angew Chem Int Ed Engl
; 51(36): 9071-4, 2012 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22887962
8.
Design and synthesis of conformationally constrained N,N-disubstituted 1,4-diazepanes as potent orexin receptor antagonists.
Bioorg Med Chem Lett
; 20(7): 2311-5, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20207138
9.
Discovery of 3,9-diazabicyclo[4.2.1]nonanes as potent dual orexin receptor antagonists with sleep-promoting activity in the rat.
Bioorg Med Chem Lett
; 20(14): 4201-5, 2010 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20610153
10.
Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.
J Med Chem
; 58(20): 8154-65, 2015 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26397965
11.
Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.
ChemMedChem
; 9(2): 311-22, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24376006
12.
The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey.
Neuropharmacology
; 64: 215-23, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22750078
13.
Pharmacological characterization of MK-6096 - a dual orexin receptor antagonist for insomnia.
Neuropharmacology
; 62(2): 978-87, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22019562
14.
Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties.
ChemMedChem
; 7(3): 415-24, 337, 2012 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-22307992
15.
Correction to Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.
J Med Chem
; 59(1): 486, 2016 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26709958
16.
Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia.
J Med Chem
; 53(14): 5320-32, 2010 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-20565075
17.
Discovery of a potent, CNS-penetrant orexin receptor antagonist based on an n,n-disubstituted-1,4-diazepane scaffold that promotes sleep in rats.
ChemMedChem
; 4(7): 1069-74, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19418500
18.
Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP.
Bioorg Med Chem Lett
; 17(20): 5677-82, 2007 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17766111
19.
Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP.
Bioorg Med Chem Lett
; 17(19): 5390-5, 2007 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17761419