1.
Bioorg Med Chem Lett
; 21(5): 1527-31, 2011 Mar 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21277198
RESUMO
The structure-human CXCR3 binding affinity relationship of a series of pyridyl-piperazinyl-piperidine derivatives was explored. The optimization campaign highlighted the pronounced effect of 2'-piperazine substitution on CXCR3 receptor affinity. Analog 18j, harboring a 2'(S)-ethylpiperazine moiety, exhibited a human CXCR3 IC(50) of 0.2 nM.