Detalhe da pesquisa
1.
Structure of the essential inner membrane lipopolysaccharide-PbgA complex.
Nature
; 584(7821): 479-483, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32788728
2.
Characterization of Antineovascularization Activity and Ocular Pharmacokinetics of Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GNE-947.
Drug Metab Dispos
; 48(5): 408-419, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32132091
3.
Applying Stable Isotope Labeled Amino Acids in Micropatterned Hepatocyte Coculture to Directly Determine the Degradation Rate Constant for CYP3A4.
Drug Metab Dispos
; 45(6): 581-585, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28289057
4.
Brain Distribution and Efficacy of the Brain Penetrant PI3K Inhibitor GDC-0084 in Orthotopic Mouse Models of Human Glioblastoma.
Drug Metab Dispos
; 44(12): 1881-1889, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27638506
5.
Distribution of the phosphatidylinositol 3-kinase inhibitors Pictilisib (GDC-0941) and GNE-317 in U87 and GS2 intracranial glioblastoma models-assessment by matrix-assisted laser desorption ionization imaging.
Drug Metab Dispos
; 42(7): 1110-6, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24754926
6.
Yale School of Public Health Symposium on tissue imaging mass spectrometry: illuminating phenotypic heterogeneity and drug disposition at the molecular level.
Hum Genomics
; 12(1): 10, 2018 02 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-29482659
7.
Role of P-glycoprotein on the brain penetration and brain pharmacodynamic activity of the MEK inhibitor cobimetinib.
Mol Pharm
; 11(11): 4199-207, 2014 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-25243894
8.
Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2.
Bioorg Med Chem Lett
; 24(12): 2635-9, 2014 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24813737
9.
Evaluation of an accurate mass approach for the simultaneous detection of drug and metabolite distributions via whole-body mass spectrometric imaging.
Anal Chem
; 84(16): 7158-65, 2012 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22827834
10.
A rapid derivatization based LC-MS/MS method for quantitation of short chain fatty acids in human plasma and urine.
Bioanalysis
; 11(8): 741-753, 2019 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-30993998
11.
Tumor Drug Penetration Measurements Could Be the Neglected Piece of the Personalized Cancer Treatment Puzzle.
Clin Pharmacol Ther
; 106(1): 148-163, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30107040
12.
Lung-restricted inhibition of Janus kinase 1 is effective in rodent models of asthma.
Sci Transl Med
; 10(468)2018 11 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30463918
13.
Correction: Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors.
PLoS One
; 13(1): e0192059, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29370292
14.
Feasibility Assessment of a MALDI FTICR Imaging Approach for the 3D Reconstruction of a Mouse Lung.
J Am Soc Mass Spectrom
; 28(8): 1709-1715, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28401432
15.
A multi-matrix HILIC-MS/MS method for the quantitation of endogenous small molecule neurological biomarker N-acetyl aspartic acid (NAA).
J Pharm Biomed Anal
; 140: 11-19, 2017 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28334553
16.
Tissue Localization of Glycosphingolipid Accumulation in a Gaucher Disease Mouse Brain by LC-ESI-MS/MS and High-Resolution MALDI Imaging Mass Spectrometry.
SLAS Discov
; 22(10): 1218-1228, 2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28714776
17.
Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors.
PLoS One
; 12(10): e0185862, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28982154
18.
Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development.
J Med Chem
; 59(12): 5650-60, 2016 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-27227380
19.
Imaging MALDI MS of Dosed Brain Tissues Utilizing an Alternative Analyte Pre-extraction Approach.
J Am Soc Mass Spectrom
; 26(6): 967-73, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25840813
20.
Collagenase as an effective tool for drug quantitation in tissues.
Bioanalysis
; 7(9): 1069-79, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26039805