False recall is associated with larger caudate in males but not in females.

After learning semantically related words, some people are more likely than others to incorrectly recall unstudied but semantically related lures (i.e., Deese-Roediger-McDermott [DRM] false recall). Previous studies have suggested that neural activity in subcortical regions (e.g., the caudate) is involved in false memory, and that there may be sex differences in the neural basis of false memory. However, sex-specific associations between subcortical volumes and false memory are not well understood. This study investigated whether sex modulates the associations between subcortical volumes and DRM false recall in 400 healthy college students. Volumes of subcortical regions including the caudate, accumbens, amygdala, hippocampus, pallidum, putamen and thalamus were obtained from structural magnetic resonance images and measured using FreeSurfer. The results showed that males had lower true and false recall but larger subcortical volumes than females. Interestingly, higher false recall was associated with a larger caudate in males, but not in females. This association was significant after controlling for age and intracranial volume. This study provides new evidence on the neural basis of false recall. It suggests that the caudate plays a role in false recall in young men, and that future studies of the neural correlates of false memory should consider sex differences.

Dynamic changes in neural representations underlie the repetition effect on false memory.

Restudying word lists (e.g., dream, awake, and bed) strengthens true memory of the studied words and reduces false memory for unstudied but semantically related lures (e.g., sleep). Yet, the neural mechanisms involved in this repetition effect on false memory remain unclear. Possible mechanisms involve item-specific and semantic neural representations at encoding, and the memory strength between encoding and retrieval. This study first replicated the behavioral results (Exp. 1) and then investigated various neural mechanisms by using slow event-related functional magnetic resonance imaging (fMRI) and representational similarity analysis (Exp. 2). Behavioral results confirmed that restudy improved true memory and reduced false memory. The fMRI results showed that restudy induced item-specific neural representations at encoding in the left occipital pole, but reduced neural overlap between semantic representations at encoding in the left temporal pole. Individual differences in these two encoding neural mechanisms were correlated with the behavioral measure of false memory, with greater restudy-induced representational changes at encoding (item-specific neural representations and reduced neural overlap between semantic representations) being associated with lower false memory. Moreover, restudy enhanced the memory strength between encoding and retrieval in the visuoparietal cortex but reduced it in the frontal cortex. These findings suggest that dynamic changes in neural representations underlie the repetition effect on false memory, supporting a dual-coding neural framework.

Multiple interactive memory representations underlie the induction of false memory.

Theoretical and computational models such as transfer-appropriate processing (TAP) and global matching models have emphasized the encoding-retrieval interaction of memory representations in generating false memories, but relevant neural mechanisms are still poorly understood. By manipulating the sensory modalities (visual and auditory) at different processing stages (learning and test) in the Deese-Roediger-McDermott task, we found that the auditory-learning visual-test (AV) group produced more false memories (59%) than the other three groups (42∼44%) [i.e., visual learning visual test (VV), auditory learning auditory test (AA), and visual learning auditory test (VA)]. Functional imaging results showed that the AV group's proneness to false memories was associated with (i) reduced representational match between the tested item and all studied items in the visual cortex, (ii) weakened prefrontal monitoring process due to the reliance on frontal memory signal for both targets and lures, and (iii) enhanced neural similarity for semantically related words in the temporal pole as a result of auditory learning. These results are consistent with the predictions based on the TAP and global matching models and highlight the complex interactions of representations during encoding and retrieval in distributed brain regions that contribute to false memories.

Cross-stage neural pattern similarity in the hippocampus predicts false memory derived from post-event inaccurate information.

The misinformation effect occurs when people's memory of an event is altered by subsequent inaccurate information. No study has systematically tested theories about the dynamics of human hippocampal representations during the three stages of misinformation-induced false memory. This study replicates behavioral results of the misinformation effect, and investigates the cross-stage pattern similarity in the hippocampus and cortex using functional magnetic resonance imaging. Results show item-specific hippocampal pattern similarity between original-event and post-event stages. During the memory-test stage, hippocampal representations of original information are weakened for true memory, whereas hippocampal representations of misinformation compete with original information to create false memory. When false memory occurs, this conflict is resolved by the lateral prefrontal cortex. Individuals' memory traces of post-event information in the hippocampus predict false memory, whereas original information in the lateral parietal cortex predicts true memory. These findings support the multiple-trace model, and emphasize the reconstructive nature of human memory.

Age Effects on Neural Discriminability and Monitoring Process During Memory Retrieval for Auditory Words.

After hearing a list of words (e.g., dream, awake, and bed), older adults tended to have more difficulty than younger adults in distinguishing targets (e.g., dream) from lures (e.g., sleep) and foils (e.g., pen) in a visual recognition test. Age-related reduction in neural discriminability in the visual cortex has been linked to deficits in memory discriminability of pictures. However, no study has examined age differences in auditory discrimination and prefrontal monitoring during true and false memory retrieval after hearing words. The current study used a visual recognition test following an auditory study of words and showed that older adults had lower true recognition and higher propensity for high-confidence false recognition compared to young adults. Using classification-based multivariate pattern analysis for functional neuroimaging data during memory retrieval, we found that neural activation patterns in the primary auditory cortex could be used to distinguish between auditorily-studied targets and unstudied lures in young adults, but not in older adults. Moreover, prefrontal monitoring for lures was weaker in older adults as compared to young adults. Individual differences analysis showed that neural discriminability in the primary auditory cortex was positively related to true recognition, whereas prefrontal activation for lures was negatively related to the propensity for high-confidence false recognition in young adults but not in older adults. Together, age differences in true and false memories following auditory study are associated with reduced neural discriminability in the primary auditory cortex and reduced prefrontal monitoring during retrieval.