Detalhe da pesquisa
1.
Discovery of quinazoline HPK1 inhibitors with high cellular potency.
Bioorg Med Chem
; 92: 117423, 2023 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37531921
2.
Discovery of M5049: A Novel Selective Toll-Like Receptor 7/8 Inhibitor for Treatment of Autoimmunity.
J Pharmacol Exp Ther
; 376(3): 397-409, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33328334
3.
Discovery of 4-aminopyrimidine analogs as highly potent dual P70S6K/Akt inhibitors.
Bioorg Med Chem Lett
; 50: 128352, 2021 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34481987
4.
Discovery of potent and selective reversible Bruton's tyrosine kinase inhibitors.
Bioorg Med Chem
; 40: 116163, 2021 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33932711
5.
Synthesis and SAR development of quinoline analogs as novel P2X7 receptor antagonists.
Bioorg Med Chem Lett
; 29(13): 1660-1664, 2019 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31031055
6.
Discovery of a novel series of pyridine and pyrimidine carboxamides as potent and selective covalent inhibitors of Btk.
Bioorg Med Chem Lett
; 28(21): 3419-3424, 2018 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30290988
7.
Discovery of potent, highly selective covalent irreversible BTK inhibitors from a fragment hit.
Bioorg Med Chem Lett
; 28(17): 2939-2944, 2018 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30122225
8.
Optimization of the efflux ratio and permeability of covalent irreversible BTK inhibitors.
Bioorg Med Chem Lett
; 28(20): 3307-3311, 2018 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30243592
9.
Corrigendum to "Discovery of 4-aminopyrimidine analogs as highly potent dual P70S6K/Akt inhibitors" [Bioorgan. Med. Chem. Lett. 50 (2021) 128352].
Bioorg Med Chem Lett
; 67: 128758, 2022 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35484006
10.
Selective Wee1 Inhibitors Led to Antitumor Activity In Vitro and Correlated with Myelosuppression.
ACS Med Chem Lett
; 14(5): 566-576, 2023 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37197456
11.
Pyrrolamide DNA gyrase inhibitors: fragment-based nuclear magnetic resonance screening to identify antibacterial agents.
Antimicrob Agents Chemother
; 56(3): 1240-6, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22183167
12.
Pyrrolamide DNA gyrase inhibitors: optimization of antibacterial activity and efficacy.
Bioorg Med Chem Lett
; 21(24): 7416-20, 2011 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22041057
13.
Discovery of Covalent Bruton's Tyrosine Kinase Inhibitors with Decreased CYP2C8 Inhibitory Activity.
ChemMedChem
; 16(24): 3653-3662, 2021 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34582626
14.
Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers.
J Med Chem
; 64(19): 14603-14619, 2021 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34596404
15.
Discovery of Affinity-Based Probes for Btk Occupancy Assays.
ChemMedChem
; 14(2): 217-223, 2019 01 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30521698
16.
Discovery of Evobrutinib: An Oral, Potent, and Highly Selective, Covalent Bruton's Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases.
J Med Chem
; 62(17): 7643-7655, 2019 09 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31368705
17.
Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099).
J Med Chem
; 57(14): 6060-82, 2014 Jul 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24959892
18.
Novel DNA gyrase inhibitors: microbiological characterisation of pyrrolamides.
Int J Antimicrob Agents
; 41(1): 28-35, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23142086
19.
Fragment-to-hit-to-lead discovery of a novel pyridylurea scaffold of ATP competitive dual targeting type II topoisomerase inhibiting antibacterial agents.
J Med Chem
; 56(21): 8712-35, 2013 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24098982