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Bioorg Med Chem Lett
; 15(6): 1749-53, 2005 Mar 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15745833
RESUMO
The chemoattractant receptor-homologous molecule expressed on T(H)2 cells (CRTH-2), also found on eosinophils and basophils, is a prostaglandin D2 receptor involved in the recruitment of these cell types during an inflammatory response. In this report, we describe the synthesis and optimization of a ramatroban isostere that is a selective and potent antagonist of CRTH-2 which may be useful in the treatment of certain diseases.