Detalhe da pesquisa
1.
Synthesis and evaluation of hedgehog signaling inhibitor with novel core system.
Bioorg Med Chem
; 23(15): 4777-4791, 2015 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26094943
2.
Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists.
Bioorg Med Chem
; 21(18): 5725-37, 2013 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23928071
3.
Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a]indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane permeability across MDR1 expressing cells.
Bioorg Med Chem
; 21(24): 7938-54, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24169315
4.
Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: modification of the core skeleton for improved solubility.
Bioorg Med Chem
; 20(18): 5507-17, 2012 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22898254
5.
Discovery of pyrrolo[3,2-c]quinoline-4-one derivatives as novel hedgehog signaling inhibitors.
Bioorg Med Chem
; 20(18): 5496-506, 2012 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22910224
6.
Multimeric bivalent immunogens from recombinant tetanus toxin HC fragment, synthetic hexasaccharides, and a glycopeptide adjuvant.
Glycoconj J
; 27(1): 69-77, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19757026
7.
Design, Synthesis, and Biological Evaluation of Retinoic Acid-Related Orphan Receptor γt (RORγt) Agonist Structure-Based Functionality Switching Approach from In House RORγt Inverse Agonist to RORγt Agonist.
J Med Chem
; 62(3): 1167-1179, 2019 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30652849
8.
Gene Signature-Based Approach Identified MEK1/2 as a Potential Target Associated With Relapse After Anti-TNFα Treatment for Crohn's Disease.
Inflamm Bowel Dis
; 24(6): 1251-1265, 2018 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29669006
9.
Chemical synthesis of peptidoglycan fragments for elucidation of the immunostimulating mechanism.
J Endotoxin Res
; 13(3): 189-96, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17621561
10.
Discovery of a Novel Scaffold as an Indoleamine 2,3-Dioxygenaseâ 1 (IDO1) Inhibitor Based on the Pyrrolopiperazinone Alkaloid, Longamideâ B.
ChemMedChem
; 11(24): 2682-2689, 2016 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27863031
11.
Design and synthesis of potent inhibitor of apoptosis (IAP) proteins antagonists bearing an octahydropyrrolo[1,2-a]pyrazine scaffold as a novel proline mimetic.
J Med Chem
; 56(3): 1228-46, 2013 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23298277
12.
Synthesis of peptidoglycan fragments and evaluation of their biological activity.
Org Biomol Chem
; 4(2): 232-42, 2006 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-16391765