RESUMO
In a remarkable recent study, Miao et al. reveal that gasdermin D N-terminal (GSDMD-NT) instigates mitochondrial damage in pyroptosis by forming pores in inner and outer mitochondrial membranes (OMMs). The authors highlight the key role of mitochondrial cardiolipin in the action of GSDMD-NT, and significantly advance our understanding of this inflammatory cell death mechanism.
Assuntos
Peptídeos e Proteínas de Sinalização Intracelular , Piroptose , Humanos , Peptídeos e Proteínas de Sinalização Intracelular/metabolismo , Cardiolipinas/metabolismo , Gasderminas , Proteínas de Neoplasias/metabolismo , Inflamassomos/metabolismoRESUMO
Tumors compromise T cell functionality through various mechanisms, including the induction of a nutrient-scarce microenvironment, leading to lipid accumulation and metabolic reprogramming. Hunt et al. elucidate acetyl-CoA carboxylase's crucial role in regulating lipid metabolism in CD8+ T cells, uncovering a novel metabolic strategy to potentiate antitumor immune responses.
Assuntos
Acetil-CoA Carboxilase , Linfócitos T CD8-Positivos , Linfócitos T CD8-Positivos/metabolismo , Linfócitos T CD8-Positivos/imunologia , Humanos , Acetil-CoA Carboxilase/metabolismo , Animais , Neoplasias/imunologia , Neoplasias/metabolismo , Metabolismo dos Lipídeos , Microambiente Tumoral/imunologiaRESUMO
Mendez-Gomez et al. recently demonstrated the transformative potential of RNA-lipid particle aggregates (RNA-LPAs) in immunotherapy. By reprogramming the tumor microenvironment (TME) and potentiating antitumor immunity, RNA-LPAs target primary tumors and elicit robust systemic immunity. This innovative platform holds promise for translating preclinical success into tangible clinical benefits.
Assuntos
Imunoterapia , Neoplasias , RNA , Microambiente Tumoral , Humanos , Imunoterapia/métodos , Microambiente Tumoral/imunologia , Neoplasias/terapia , Neoplasias/imunologia , Animais , RNA/uso terapêutico , RNA/imunologia , RNA/química , Lipídeos/químicaRESUMO
Iron oxide (IO) nanoparticles (NPs) have gained significant attention in the field of biomedicine, particularly in drug targeting and cancer therapy. Their potential in magnetic drug targeting (MDT) and ferroptosis-based cancer therapy is highly promising. IO NPs serve as an effective drug delivery system (DDS), utilizing external magnetic fields (EMFs) to target cancer cells while minimizing damage to healthy organs. Additionally, IO NPs can generate reactive oxygen species (ROS) and induce ferroptosis, resulting in cytotoxic effects on cancer cells. This article explores how IO NPs can potentially revolutionize cancer research, focusing on their applications in MDT and ferroptosis-based therapy.