Detalhe da pesquisa
1.
Genetic and pharmacological manipulation of glyoxalase 1 regulates voluntary ethanol consumption in mice.
Addict Biol
; 22(2): 381-389, 2017 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26691867
2.
Glo1 inhibitors for neuropsychiatric and anti-epileptic drug development.
Biochem Soc Trans
; 42(2): 461-7, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24646261
3.
A simple, general approach of allosteric coagulation enzyme inhibition through monosulfated hydrophobic scaffolds.
Bioorg Med Chem Lett
; 24(24): 5716-5720, 2014 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25453807
4.
Peroxisome proliferation-activated receptor δ agonist GW0742 interacts weakly with multiple nuclear receptors, including the vitamin D receptor.
Biochemistry
; 52(24): 4193-203, 2013 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-23713684
5.
On scaffold hopping: challenges in the discovery of sulfated small molecules as mimetics of glycosaminoglycans.
Bioorg Med Chem Lett
; 23(1): 355-9, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23164711
6.
Parallel Chemistry Approach to Identify Novel Nuclear Receptor Ligands Based on the GW0742 Scaffold.
ACS Comb Sci
; 19(10): 646-656, 2017 10 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28825467
7.
6-Hydroxyflavone and derivatives exhibit potent anti-inflammatory activity among mono-, di- and polyhydroxylated flavones in kidney mesangial cells.
PLoS One
; 10(3): e0116409, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25790236
8.
Antitumor Activity of 3-Indolylmethanamines 31B and PS121912.
Anticancer Res
; 35(11): 6001-7, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26504023
9.
Modulation of Transcription mediated by the Vitamin D Receptor and the Peroxisome Proliferator-Activated Receptor δ in the presence of GW0742 analogs.
J Biomol Res Ther
; 3(1)2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25485183
10.
Development of novel Vitamin D Receptor-Coactivator Inhibitors.
ACS Med Chem Lett
; 5(2): 199-204, 2014 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24799995
11.
IDENTIFICATION OF VDR ANTAGONISTS AMONG NUCLEAR RECEPTOR LIGANDS USING VIRTUAL SCREENING.
Nucl Receptor Res
; 12014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25419525
12.
Anticancer activity of VDR-coregulator inhibitor PS121912.
Cancer Chemother Pharmacol
; 74(4): 787-98, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25107568
13.
Designing allosteric regulators of thrombin. Exosite 2 features multiple subsites that can be targeted by sulfated small molecules for inducing inhibition.
J Med Chem
; 56(12): 5059-70, 2013 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-23718540
14.
PT19c, Another Nonhypercalcemic Vitamin D2 Derivative, Demonstrates Antitumor Efficacy in Epithelial Ovarian and Endometrial Cancer Models.
Genes Cancer
; 4(11-12): 524-34, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24386512
15.
Designing allosteric regulators of thrombin. Monosulfated benzofuran dimers selectively interact with Arg173 of exosite 2 to induce inhibition.
J Med Chem
; 55(15): 6888-97, 2012 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-22788964
16.
Rational design of potent, small, synthetic allosteric inhibitors of thrombin.
J Med Chem
; 54(15): 5522-31, 2011 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-21714536