Detalhe da pesquisa
1.
NRX-0492 degrades wild-type and C481 mutant BTK and demonstrates in vivo activity in CLL patient-derived xenografts.
Blood
; 141(13): 1584-1596, 2023 03 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-36375120
2.
PI3K inhibitors in chronic lymphocytic leukemia: where do we go from here?
Haematologica
; 108(1): 9-21, 2023 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35899388
3.
T-helper cell regulation of CD45 phosphatase activity by galectin-1 and CD43 governs chronic lymphocytic leukaemia proliferation.
Br J Haematol
; 198(3): 556-573, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35655388
4.
Approach to a patient with "double refractory" chronic lymphocytic leukemia: "Double, double toil and trouble" (Shakespeare).
Am J Hematol
; 97 Suppl 2: S19-S25, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36125036
5.
Carboxyl-Terminal Src Kinase Binds CD28 upon Activation and Mutes Downstream Signaling.
J Immunol
; 203(4): 1055-1063, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31292214
6.
B cell signalling pathways-New targets for precision medicine in chronic lymphocytic leukaemia.
Scand J Immunol
; 92(5): e12931, 2020 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-32640099
7.
COVID-19 in patients with CLL: improved survival outcomes and update on management strategies.
Blood
; 138(18): 1768-1773, 2021 11 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34297826
8.
Functional testing of relapsed chronic lymphocytic leukemia guides precision medicine and maps response and resistance mechanisms. An index case.
Haematologica
; 107(8): 1994-1998, 2022 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35236056
9.
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.
Nature
; 471(7340): 637-41, 2011 Mar 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-21455181
10.
T-cell co-stimulation through the CD2 and CD28 co-receptors induces distinct signalling responses.
Biochem J
; 460(3): 399-410, 2014 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24665965
11.
Spatial organization of transmembrane receptor signalling.
EMBO J
; 29(16): 2677-88, 2010 Aug 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-20717138
12.
Interleukin-33 drives a proinflammatory endothelial activation that selectively targets nonquiescent cells.
Arterioscler Thromb Vasc Biol
; 33(2): e47-55, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23162017
13.
Immunophenotyping with (phospho)protein profiling and fluorescent cell barcoding for single-cell signaling analysis and biomarker discovery.
NPJ Precis Oncol
; 8(1): 107, 2024 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38769096
14.
Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127.
Science
; 383(6682): eadi5798, 2024 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38301010
15.
Modulation of proximal signaling in normal and transformed B cells by transmembrane adapter Cbp/PAG.
Exp Cell Res
; 318(14): 1611-9, 2012 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22659621
16.
A tumor microenvironment model of chronic lymphocytic leukemia enables drug sensitivity testing to guide precision medicine.
Cell Death Discov
; 9(1): 125, 2023 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37055391
17.
Standardized assays to monitor drug sensitivity in hematologic cancers.
Cell Death Discov
; 9(1): 435, 2023 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38040674
18.
Clinical forecasting of acute myeloid leukemia using ex vivo drug-sensitivity profiling.
Cell Rep Methods
; 3(12): 100654, 2023 Dec 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38065095
19.
Determining drug dose in the era of targeted therapies: playing it (un)safe?
Blood Cancer J
; 12(8): 123, 2022 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35999205
20.
Computational Pipeline for Rational Drug Combination Screening in Patient-Derived Cells.
Methods Mol Biol
; 2449: 327-348, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35507270