RESUMO
New biomarkers of effect of some controlled ambient air pollutants (formaldehyde, carbon monoxide and TSP) were found in two surveys of Moscow residents (apparently healthy and outpatients with allergic diseases) with a help of screening system of biochemical and immunological parameters. Possible mechanisms of the effects, including interference of atmospheric carbon monoxide and sulfur dioxide with corresponding endogenous second messengers, are discussed.
Assuntos
Biomarcadores/análise , Doença Ambiental/epidemiologia , Imunidade , Material Particulado/efeitos adversos , Vigilância da População/métodos , Saúde Pública , População Urbana , Adulto , Saúde Ambiental , Doença Ambiental/diagnóstico , Doença Ambiental/metabolismo , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Moscou/epidemiologia , Estudos Retrospectivos , Adulto JovemRESUMO
The paper presents the results of investigating the phenotypic polymorphism of a number of biochemical and immunological parameters (the values of oxidative stress, the activity of catalase and glutathione-S-transferase in red blood cells, the serum levels of catecholamines, tumor-necrosis factor-?, and IgG antibody subclasses) in the authors' hygienic studies of genotypic and nongenotypic population samples.
Assuntos
Indicadores Básicos de Saúde , Higiene , Estresse Oxidativo , Polimorfismo Genético , Biomarcadores/sangue , Catalase/sangue , Catalase/genética , Catecolaminas/sangue , Exposição Ambiental/análise , Exposição Ambiental/estatística & dados numéricos , Eritrócitos/enzimologia , Genótipo , Glutationa Transferase/sangue , Glutationa Transferase/genética , Humanos , Moscou , Estresse Oxidativo/genética , Fenótipo , Fator de Necrose Tumoral alfa/sangue , Fator de Necrose Tumoral alfa/genéticaRESUMO
The experimental study of the biological activity of the modified calcium chloride produced by a Volgograd plant and that of ash-and-slag of the pharmaceuticals resulting after combustion of a pyrolytic mixture of filtration burning could establish various hazards of these substances.